Patents by Inventor Sandra Chapman

Sandra Chapman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of a Rock Inhibitor to Sustain Primary Human Keratinocytes in a Proliferative State
    Publication number: 20140322809
    Abstract: Disclosed herein is the finding that treatment with a ROCK inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a ROCK inhibitor. Also provided are immortalized primary keratinocytes produced by the described method, as well as organotypic tissue equivalents and cell cultures comprising the immortalized primary keratinocytes. Furthermore, ROCK inhibitor-treated cells show a greatly increased ability to support viral DNA replication of both “low risk” and “high risk” HPV genomes, indicating that ROCK inhibitors will be useful for studying the life cycles of a wide range of HPVs.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 30, 2014
    Applicants: The United States of America as Represented by the Secretary, Department of Health and Human Service, Georgetown University
    Inventors: Alison McBride, Sandra Chapman, Richard Schlegel, Xuefeng Liu
  • Use of a rock inhibitor to sustain primary human keratinocytes in a proliferative state
    Patent number: 8637310
    Abstract: Disclosed herein is the finding that treatment with a ROCK inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a ROCK inhibitor. Also provided are immortalized primary keratinocytes produced by the described method, as well as organotypic tissue equivalents and cell cultures comprising the immortalized primary keratinocytes. Furthermore, ROCK inhibitor-treated cells show a greatly increased ability to support viral DNA replication of both “low risk” and “high risk” HPV genomes, indicating that ROCK inhibitors will be useful for studying the life cycles of a wide range of HPVs.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: January 28, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Alison McBride, Sandra Chapman, Jonathan Vogel, Atsushi Terunuma
  • USE OF A ROCK INHIBITOR TO SUSTAIN PRIMARY HUMAN KERATINOCYTES IN A PROLIFERATIVE STATE
    Publication number: 20110243903
    Abstract: Disclosed herein is the finding that treatment with a ROCK inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a ROCK inhibitor. Also provided are immortalized primary keratinocytes produced by the described method, as well as organotypic tissue equivalents and cell cultures comprising the immortalized primary keratinocytes. Furthermore, ROCK inhibitor-treated cells show a greatly increased ability to support viral DNA replication of both “low risk” and “high risk” HPV genomes, indicating that ROCK inhibitors will be useful for studying the life cycles of a wide range of HPVs.
    Type: Application
    Filed: December 4, 2009
    Publication date: October 6, 2011
    Inventors: Alison McBride, Sandra Chapman, Jonathan Vogel, Atsushi Terunuma