Patents by Inventor Sandra Cicuzza

Sandra Cicuzza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytochrome P450 Induction Assay
    Publication number: 20070264674
    Abstract: A method for identifying compounds that can induce expression of cytochrome P450, in particular, expression of the CYP3A4 isoform, is described. The method provides a reporter gene operably linked to a composite promoter comprising in tandem one or more cis-acting elements, which are bound by activated pregnane X receptor (PXR), operably linked to a heterologous promoter. Analytes, which are inducers CYP3A4 expression via PXR activation, induce expression of the reporter gene.
    Type: Application
    Filed: August 15, 2005
    Publication date: November 15, 2007
    Inventors: Giacomo Paonessa, Sandra Cicuzza, Ralph Laufer