Patents by Inventor Sandra Diaz

Sandra Diaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210062171
    Abstract: The present disclosure relates to novel sialidase enzymes having a preference for cleaving N-glycolylneuraminic acid (Neu5Gc) from glycoconjugates over cleaving N-acetylneuraminic acid (Neu5Ac). The present disclosure further provides the polypeptide of such novel sialidase and its catalytic pockets; the recombinant host cells expressing the same, as well as the enzymatic, pharmaceutical, and consumable compositions comprising such novel sialidases. Probiotic compositions comprising a bacterium that expresses the sialidase having a preference for Neu5Gc over Neu5Ac, and methods for removing Neu5Gc from consumable products are also provided. Also disclosed are methods for treating or preventing various diseases, disorders, and inflammatory conditions in a subject using the novel sialidases.
    Type: Application
    Filed: August 28, 2020
    Publication date: March 4, 2021
    Applicant: The Regents of the University of California
    Inventors: Karsten Zengler, Ajit Varki, Frederico Da Silva, Sandra Diaz, Cameron Martino, Geoffrey Chang, Steven Rees, Livia Soares Zaramela
  • Publication number: 20110195921
    Abstract: The disclosure provides a method of reducing or eliminating Neu5Gc in a cell culture or in a human subject. The method includes flooding the system with the human sialic acid i\7-acetylneuraminic acid (Neu5Ac) in glycosidically-bound or free form, or its precursor N-acetylmannosamine (ManNAc) in an amount sufficient to metabolically compete out the Neu5Gc, either as it enters the cells for the first time or when it recycles from break-down of preexisting cellular molecules. Additionally, Neu5Ac feeding results in reduction of Neu5Gc expression even in some animal cells capable of Neu5Gc production.
    Type: Application
    Filed: September 9, 2009
    Publication date: August 11, 2011
    Inventors: Ajit Varki, Sandra Diaz, Rachel Taylor
  • Publication number: 20100221770
    Abstract: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in biological materials, such as food and clinical specimens. Such detection and analysis is facilitated by the use of Neu5Gc specific antibodies. The present invention also relates to the detection of antiNeu5Gc antibodies in clinical samples, as well as the production of anti-Neu5Gc specific antibodies.
    Type: Application
    Filed: March 17, 2010
    Publication date: September 2, 2010
    Inventors: Ajit Varki, Pam Tangvoranuntakul, Nissi Varki, Elaine Muchmore, Pascal Gagneux, Sandra Diaz
  • Patent number: 7682794
    Abstract: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in bio-logical materials, such as food and clinical specimens. Such detection and analysis is facilitated by the use of Neu5Gc specific antibodies. The present invention also relates to the detection of anti Neu5Gc antibodies in clinical samples, as well as the production of anti-Neu5Gc specific antibodies.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: March 23, 2010
    Assignee: The Regents of the University of California
    Inventors: Ajit Varki, Pam Tangvoranuntakul, Nissi Varki, Elaine Muchmore, Pascal Gagneux, Sandra Diaz