Patents by Inventor Sandra Fernandes

Sandra Fernandes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and kits for detecting a fusion messenger RNA transcript or a polypeptide encoded by the fusion messenger RNA transcript
    Patent number: 10890579
    Abstract: The present invention relates to methods and kits for detecting a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript. The method includes obtaining a biological sample from a subject and providing one or more reagents capable of binding a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript, wherein the fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript comprises the 3? end of ex on 25 of INPP5D fused to the 5? end of ex on 2 of ATG16L1 or the polypeptide encoded by the 3? end of ex on 25 of INPP5D fused to the 5? end of ex on 2 of ATG16L1, respectively.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: January 12, 2021
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Frank Middleton, William G. Kerr, Sandra Fernandes Denney
  • Tryptamine-based ship inhibitors for the treatment of cancer
    Patent number: 10736877
    Abstract: The present disclosure provides compositions that inhibit the SH2-containing inositol 5?-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: August 11, 2020
    Assignees: SYRACUSE UNIVERSITY, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY of New York
    Inventors: William G. Kerr, Sandra Fernandes Denney, John D. Chisholm
  • METHODS AND KITS FOR DETECTING A FUSION MESSENGER RNA TRANSCRIPT OR A POLYPEPTIDE ENCODED BY THE FUSION MESSENGER RNA TRANSCRIPT
    Publication number: 20200041495
    Abstract: The present invention relates to methods and kits for detecting a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript. The method includes obtaining a biological sample from a subject and providing one or more reagents capable of binding a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript, wherein the fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript comprises the 3? end of ex on 25 of INPP5D fused to the 5? end of ex on 2 of ATG16L1 or the polypeptide encoded by the 3? end of ex on 25 of INPP5D fused to the 5? end of ex on 2 of ATG16L1, respectively.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 6, 2020
    Inventors: Frank MIDDLETON, William G. KERR, Sandra Fernandes DENNEY
  • TRYPTAMINE-BASED SHIP INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20170189380
    Abstract: The present disclosure provides compositions that inhibit the SH2-containing inositol 5?-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.
    Type: Application
    Filed: December 30, 2016
    Publication date: July 6, 2017
    Inventors: William G. KERR, Sandra Fernandes, John D. Chisholm
  • ASSAY FOR SHIP1 EXPRESSION, ACTIVITY AND SEQUENCE ALTERATIONS AS A PREDICTOR OF INFLAMMATORY BOWEL DISEASE RISK
    Publication number: 20140287943
    Abstract: The present disclosure is directed to detecting colon disorders by measuring the expression of SHIP1 in a sample of PBMCs. One method includes the following steps, obtaining a sample including peripheral blood mononuclear cells (PBMCs) from a subject and determining whether SHIP1 is underexpressed in the PBMCs or lacks normal enzymatic activity. The present disclosure is also directed to a method of determining the expression of SHIP1 protein expression and SHIP1 enzyme activity in PBMCs. This method includes the following steps, obtaining a sample comprising PBMCs from a subject and determining the amount of SHIP1 in the PBMCs.
    Type: Application
    Filed: April 27, 2012
    Publication date: September 25, 2014
    Applicants: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: William G. Kerr, Gwenny M. Fuhler, Sandra Fernandes