Patents by Inventor Sandra Hoffarth

Sandra Hoffarth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting gene modifications by means of asymmetrical PCR and blocking agents
    Patent number: 9115392
    Abstract: A method of detecting at least one gene modification such as a mutation in a gene includes carrying out an asymmetric polymerase chain reaction (PCR) with a combined use of at least one detectable mutation-specific hybridization probe (sensor probe) and at least one wild-type specific blocking agent which inhibits a binding of the at least one detectable mutation-specific hybridization probe (sensor probe) to a wild-type gene so as to provide at least one of a selective intensification and an amplification of a detection of a gene segment of a mutation gene having a gene modification.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: August 25, 2015
    Assignee: UNIVERSITAET DUISBURG-ESSEN
    Inventors: Martin Schuler, Frank Breitenbuecher, Sandra Hoffarth, Sarah-Luise Stergar
  • DETECTION OF MUTATIONS, IN PARTICULAR DELETIONS OR INSERTIONS
    Publication number: 20130302798
    Abstract: A method for detecting at least one gene modification, such as a mutation in a gene, such as a gene that codes for a protein associated with at least one of a tumor and a cancer. The method includes providing a detectable hybridization probe (sensor probe) which interacts with/binds to a gene not having a gene modification (wild type gene) and with a gene having a gene modification (mutation gene). The detectable hybridization probe (sensor probe) has at least one of a higher specificity, a higher binding affinity and a higher selectivity for the gene not having a gene modification (wild type gene) compared to the gene having a gene modification (mutation gene). At least one gene modification is detected with the detectable hybridization probe (sensor probe).
    Type: Application
    Filed: July 4, 2011
    Publication date: November 14, 2013
    Applicant: UNIVERSITAET DUISBURG-ESSEN
    Inventors: Martin Schuler, Frank Breitenbuecher, Sandra Hoffarth, Sarah-Luise Boeck
  • METHOD FOR DETECTING GENE MODIFICATIONS BY MEANS OF ASYMMETRICAL PCR AND BLOCKING AGENTS
    Publication number: 20120244538
    Abstract: A method of detecting at least one gene modification such as a mutation in a gene includes carrying out an asymmetric polymerase chain reaction (PCR) with a combined use of at least one detectable mutation-specific hybridization probe (sensor probe) and at least one wild-type specific blocking agent which inhibits a binding of the at least one detectable mutation-specific hybridization probe (sensor probe) to a wild-type gene so as to provide at least one of a selective intensification and an amplification of a detection of a gene segment of a mutation gene having a gene modification.
    Type: Application
    Filed: September 9, 2010
    Publication date: September 27, 2012
    Inventors: Martin Schuler, Frank Breitenbuecher, Sandra Hoffarth, Sarah-Luise Stergar