Patents by Inventor Sandra K. Erickson

Sandra K. Erickson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically modified mouse lacking diacylglycerol acyltransferase-1 (DGAT-1) activity
    Patent number: 7745691
    Abstract: Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: June 29, 2010
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs, The J. David Gladstone Institutes
    Inventors: Robert V. Farese, Jr., Hubert C. Chen, Steven J. Smith, Sylvaine Cases, Sandra K. Erickson
  • Acyl CoA:cholesterol acyltransferase (ACAT-2)
    Patent number: 7238779
    Abstract: Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: July 3, 2007
    Assignee: The Regents of the University of California
    Inventors: Sylvaine Cases, Robert V. Farese, Jr., Sandra K. Erickson, Sabine Novak, Michel Accad
  • Acyl CoA:cholesterol acyltransferase (ACAT-2)
    Patent number: 6869937
    Abstract: Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: March 22, 2005
    Assignees: The Regents of the Universtiy of California, The United States of America as represented by the Department of Veteran Affairs
    Inventors: Sylvaine Cases, Robert V. Farese, Jr., Sandra K. Erickson, Sabine Novak, Michel Accad
  • Novel acyl CoA:cholesterol acyltransferase (ACAT-2)
    Publication number: 20040230050
    Abstract: Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity, e.g., in the treatment of gall stones.
    Type: Application
    Filed: February 12, 2004
    Publication date: November 18, 2004
    Inventors: Sylvaine Cases, Robert V. Farese, Sandra K. Erickson, Sabine Novak, Michel Accad
  • Diacylglycerol O-Acyltransferase
    Publication number: 20040078836
    Abstract: Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.
    Type: Application
    Filed: September 10, 2003
    Publication date: April 22, 2004
    Inventors: Robert V. Farese, Sylvaine Cases, Steven Smith, Sandra K. Erickson
  • Diacylglycerol O-acyltransferase
    Publication number: 20030167483
    Abstract: Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.
    Type: Application
    Filed: October 29, 2001
    Publication date: September 4, 2003
    Inventors: Robert V. Farese, Sylvaine Cases, Steven Smith, Sandra K. Erickson
  • Acyl CoA:cholesterol acyltransferase (ACAT-2)
    Patent number: 6579974
    Abstract: Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein compositions. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with ACAT-2 activity.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: June 17, 2003
    Assignees: The Regents of The University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Sylvaine Cases, Robert V. Farese, Jr., Sandra K. Erickson
  • Diacylglycerol O-Acyltransferase
    Publication number: 20030072757
    Abstract: Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.
    Type: Application
    Filed: October 16, 2002
    Publication date: April 17, 2003
    Inventors: Robert V. Farese, Sylvaine Cases, Steven Smith, Sandra K. Erickson
  • Diacylglycerol o-acyltransferase
    Patent number: 6344548
    Abstract: Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: February 5, 2002
    Assignee: The Regents of the University of California
    Inventors: Robert V. Farese, Jr., Sylvaine Cases, Steven Smith, Sandra K. Erickson