Abstract: A multiwell filtration device having at least two liquid receiving reservoirs is disclosed in which at least one of the side walls includes one or more openings for passing liquid therethrough. A filtration membrane is sealingly adhered to the side wall covering the openings of each reservoir. The reservoirs are adapted to be positioned within the wells of a multiwell plate, which receives the filtrate passing from the reservoir through the membranes. The desired orientation of the reservoirs in the multiwell plate is retained before, during or after filtration to promote efficient automated sample handling techniques.