Abstract: The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.

Abstract: The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.

Abstract: The invention relates to a system and method for localized drug delivery. The system includes a catheter and stylet. The catheter has a set of inwardly extending portions that function to provide structure to the catheter wall, prevent collapse or closure of the catheter lumen, and enable easy withdrawal of the stylet. The inwardly extending portions may take the form of substantially triangular shapes, semicircular, circular or other shapes. With the present invention, a catheter may effectively be installed in a patient in a proper location. The location may be tested through the transfer of fluid through the catheter while the stylet is in place during surgery. The catheter may be tightly sutured in place and the stylet easily withdrawn.

Abstract: An implantable infusion pump to deliver stored infusate to a desired fluid delivery site. The pump includes a collapsible fluid chamber. The pump can include a multi-stage filtration system to filter micro-emboli as well as larger particles that are inadvertently introduced into the pump system. An external member can receive the pump and provide a medium to include additional, interactive components, e.g., a bolus port, as well as provide a versatile suture structure to enable the pump to be properly secured within an implantation site. To improve volumetric efficiency, the pump can further incorporate an outlet flow passage within a movable wall of the fluid chamber.

Abstract: An implantable infusion pump to deliver stored infusate to a desired fluid delivery site. The pump includes a collapsible fluid chamber. The pump can include a multi-stage filtration system to filter micro-emboli as well as larger particles that are inadvertently introduced into the pump system. An external member can receive the pump and provide a medium to include additional, interactive components, e.g., a bolus port, as well as provide a versatile suture structure to enable the pump to be properly secured within an implantation site. To improve volumetric efficiency, the pump can further incorporate an outlet flow passage within a movable wall of the fluid chamber.

Abstract: The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.

Abstract: The present invention relates to an implantable infusion pump having a refillable infusate reservoir in fluid communication with a delivery site via a flow path. This flow path includes a flow resistance. The infusion pump includes a sensing device(s), positioned relative to the flow path, to provide data regarding a flow rate along the flow path. The infusion pump effects a division of a total flow period into at least a plurality of unit dose periods, each unit dose period effecting delivery of a unit dose of infusate. The cumulative effect of delivering the total number of unit dose periods is the delivery of a desired dose over the total flow period. The present invention permits a reservoir pressure to vary over any portion of total flow period but effects a constant-pressure state over each unit dose cycle.

Abstract: An implantable infusion pump to deliver stored infusate to a desired fluid delivery site. The pump includes a collapsible fluid chamber. The pump can include a multi-stage filtration system to filter micro-emboli as well as larger particles that are inadvertently introduced into the pump system. An external member can receive the pump and provide a medium to include additional, interactive components, e.g., a bolus port, as well as provide a versatile suture structure to enable the pump to be properly secured within an implantation site. To improve volumetric efficiency, the pump can further incorporate an outlet flow passage within a movable wall of the fluid chamber.