Patents by Inventor Sandra O'Connor
Sandra O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9662397Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.Type: GrantFiled: August 12, 2015Date of Patent: May 30, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
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Publication number: 20160030577Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.Type: ApplicationFiled: August 12, 2015Publication date: February 4, 2016Applicant: CUBIST PHARMACEUTICALS LLCInventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
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Patent number: 9138456Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.Type: GrantFiled: December 4, 2013Date of Patent: September 22, 2015Assignee: Cubist Pharmaceuticals LLCInventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
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Publication number: 20150165029Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features harmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.Type: ApplicationFiled: January 8, 2015Publication date: June 18, 2015Inventors: Walter G. Gowan, JR., Dennis D. Keith, Sandra O'Connor
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Patent number: 8968781Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.Type: GrantFiled: April 27, 2006Date of Patent: March 3, 2015Assignee: Cubist Pharmaceuticals, Inc.Inventors: Walter G. Gowan, Jr., Dennis D. Keith, Sandra O'Connor
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Publication number: 20140364380Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.Type: ApplicationFiled: December 4, 2013Publication date: December 11, 2014Applicant: Cubist Pharmaceuticals, Inc.Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
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Patent number: 8835382Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.Type: GrantFiled: November 23, 2010Date of Patent: September 16, 2014Assignee: Cubist Pharmaceuticals, Inc.Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
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Publication number: 20140135273Abstract: The present disclosure provides novel solid CB-183,315 formulations which have improved chemical stability. The chemical stability of the solid CB-183,315 is dependent on the process by which the composition is made. Solid preparations of CB-183,315 can be prepared by the following method: (a) forming an aqueous solution of CB-183,315 and at least one sugar that (e.g., sucrose, trehalose or dextran) at a pH of 2-7, preferably pH 6 and (b) converting the aqueous solution to the solid preparation of CB-183,315 (e.g., via lyophilization or spray drying).Type: ApplicationFiled: October 7, 2013Publication date: May 15, 2014Applicant: Cubist Pharmaceuticals, Inc.Inventors: Sandra O'CONNOR, Sophie Sun, Gaauri Naik
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Patent number: 8580256Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.Type: GrantFiled: June 23, 2010Date of Patent: November 12, 2013Assignee: Yeda Reseach and Development Company LimitedInventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
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Publication number: 20130109633Abstract: The present disclosure provides novel solid CB-183,315 formulations which have improved chemical stability. The chemical stability of the solid CB-183,315 is dependent on the process by which the composition is made. Solid preparations of CB-183,315 can be prepared by the following method: (a) forming an aqueous solution of CB-183,315 and at least one sugar that (e.g., sucrose, trehalose or dextran) at a pH of 2-7, preferably pH 6 and (b) converting the aqueous solution to the solid preparation of CB-183,315 (e.g., via lyophilization or spray drying).Type: ApplicationFiled: May 25, 2012Publication date: May 2, 2013Applicant: Cubist Pharmaceuticals, Inc.Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
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Publication number: 20120270772Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.Type: ApplicationFiled: November 23, 2010Publication date: October 25, 2012Applicant: CUBIST PHARMACEUTICALS, INC.Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
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Publication number: 20100330099Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.Type: ApplicationFiled: June 23, 2010Publication date: December 30, 2010Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITEDInventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, JR., Sandra O'Connor
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Patent number: 7785595Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.Type: GrantFiled: April 18, 2005Date of Patent: August 31, 2010Assignee: Yeda Research and Development Company LimitedInventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
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Publication number: 20080213366Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.Type: ApplicationFiled: April 27, 2006Publication date: September 4, 2008Applicant: Cubist Pharmaceuticals, IncInventors: Walter G. Gowan Jr, Dennis D. Keith, Sandra O'Connor
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Publication number: 20080152658Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.Type: ApplicationFiled: April 18, 2005Publication date: June 26, 2008Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Sandra O'Connor