Patents by Inventor Sandra O'Connor

Sandra O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9662397
    Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: May 30, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
  • Publication number: 20160030577
    Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
    Type: Application
    Filed: August 12, 2015
    Publication date: February 4, 2016
    Applicant: CUBIST PHARMACEUTICALS LLC
    Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
  • Patent number: 9138456
    Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: September 22, 2015
    Assignee: Cubist Pharmaceuticals LLC
    Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
  • Publication number: 20150165029
    Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features harmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.
    Type: Application
    Filed: January 8, 2015
    Publication date: June 18, 2015
    Inventors: Walter G. Gowan, JR., Dennis D. Keith, Sandra O'Connor
  • Patent number: 8968781
    Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: March 3, 2015
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Walter G. Gowan, Jr., Dennis D. Keith, Sandra O'Connor
  • Publication number: 20140364380
    Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
    Type: Application
    Filed: December 4, 2013
    Publication date: December 11, 2014
    Applicant: Cubist Pharmaceuticals, Inc.
    Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
  • Patent number: 8835382
    Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: September 16, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
  • Publication number: 20140135273
    Abstract: The present disclosure provides novel solid CB-183,315 formulations which have improved chemical stability. The chemical stability of the solid CB-183,315 is dependent on the process by which the composition is made. Solid preparations of CB-183,315 can be prepared by the following method: (a) forming an aqueous solution of CB-183,315 and at least one sugar that (e.g., sucrose, trehalose or dextran) at a pH of 2-7, preferably pH 6 and (b) converting the aqueous solution to the solid preparation of CB-183,315 (e.g., via lyophilization or spray drying).
    Type: Application
    Filed: October 7, 2013
    Publication date: May 15, 2014
    Applicant: Cubist Pharmaceuticals, Inc.
    Inventors: Sandra O'CONNOR, Sophie Sun, Gaauri Naik
  • Patent number: 8580256
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: November 12, 2013
    Assignee: Yeda Reseach and Development Company Limited
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
  • Publication number: 20130109633
    Abstract: The present disclosure provides novel solid CB-183,315 formulations which have improved chemical stability. The chemical stability of the solid CB-183,315 is dependent on the process by which the composition is made. Solid preparations of CB-183,315 can be prepared by the following method: (a) forming an aqueous solution of CB-183,315 and at least one sugar that (e.g., sucrose, trehalose or dextran) at a pH of 2-7, preferably pH 6 and (b) converting the aqueous solution to the solid preparation of CB-183,315 (e.g., via lyophilization or spray drying).
    Type: Application
    Filed: May 25, 2012
    Publication date: May 2, 2013
    Applicant: Cubist Pharmaceuticals, Inc.
    Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
  • Publication number: 20120270772
    Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
    Type: Application
    Filed: November 23, 2010
    Publication date: October 25, 2012
    Applicant: CUBIST PHARMACEUTICALS, INC.
    Inventors: Sandra O'Connor, Sophie Sun, Gaauri Naik
  • Publication number: 20100330099
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Application
    Filed: June 23, 2010
    Publication date: December 30, 2010
    Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, JR., Sandra O'Connor
  • Patent number: 7785595
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: August 31, 2010
    Assignee: Yeda Research and Development Company Limited
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
  • Publication number: 20080213366
    Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.
    Type: Application
    Filed: April 27, 2006
    Publication date: September 4, 2008
    Applicant: Cubist Pharmaceuticals, Inc
    Inventors: Walter G. Gowan Jr, Dennis D. Keith, Sandra O'Connor
  • Publication number: 20080152658
    Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
    Type: Application
    Filed: April 18, 2005
    Publication date: June 26, 2008
    Inventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Sandra O'Connor