Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A computer implemented method for planning an object which comprises a multitude of single parts and subassemblies, especially an aerospace object, the method comprising: calculating the total weights of the subassemblies and/or of the object on the basis of the data sets of the single parts and the subassemblies, wherein measured weights are used preferably to calculated weights, and calculated weights are used preferably to target weights for the calculation of the total weight(s) of the subassemblies and/or of the object, and calculating and providing the information about the shares of the used weight types in the calculated total weights. The invention further also relates to a manufacturing system and a computer implemented construction module.