Patents by Inventor Sandra Rutz

Sandra Rutz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IGFBP7 for prediction of risk of AKI when measured prior to surgery
    Patent number: 11397187
    Abstract: The present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) during or after a surgical procedure or after administration of a contrast medium. The method is based on the determination of the level of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) in a body fluid sample obtained from the patient prior to the surgical procedure or prior to the administration of a contrast medium. Further, the present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) based on the determination of the amount of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) and Cystatin C in a body fluid sample obtained from the patient. The present disclosure further encompasses kits and devices adapted to carry out the methods of the disclosed methods.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: July 26, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Andrea Horsch, Birgit Klapperich, Dirk Block, Alfred Engel, Johann Karl, Rosemarie Kientsch-Engel, Ekaterina Manuilova, Christina Rabe, Sandra Rutz, Monika Soukupova, Ursula-Henrike Wienhues-Thelen, Peter Kastner, Edelgard Anna Kaiser
  • THYMIDINE KINASE (TK-1) IN PROGNOSTIC INDICES FOR DLBCL
    Publication number: 20210199659
    Abstract: The present disclosure relates to the finding that thymidine kinase 1 (TK-1) represents a valuable biomarker in a method for determining a Prognostic Index (PI) for risk stratification of a patient with aggressive B-cell lymphoma, especially diffuse large B-cell lymphoma (DLBCL), to the use of TK-1 in such PI and to a PI comprising the marker TK-1.
    Type: Application
    Filed: February 26, 2021
    Publication date: July 1, 2021
    Inventors: Vinzent Rolny, Sandra Rutz, David Morgenstern, Boris Pinchuk, Christina Zimmermann, Martin Klammer, Franziska Sonner
  • NOVEL ANTI-THYMIDINE KINASE ANTIBODIES
    Publication number: 20210061924
    Abstract: The present invention relates to a novel monoclonal antibody that specifically binds to a conformation dependent epitope on human thymidine kinase 1 (hTK-1; SEQ ID NO:1), to methods for quantifying hTK-1 employing the antibody and to the use of the anti-hTK-1 antibody in quantifying hTK-1.
    Type: Application
    Filed: October 13, 2020
    Publication date: March 4, 2021
    Inventors: Hartmut Duefel, Alfred Engel, Frank Kroner, Thomas Meier, Sandra Rutz, Michael Schraeml, Gloria Tabares, Ulrike Kurtkaya, Boris Pinchuk, Christina Zimmermann
  • METHODS OF DETECTING A RELAPSE OF A LUNG ADENOCARCINOMA BASED ON MARKER HUMAN EPIDIDYMIS PROTEIN 4 (HE4) AND RELATED USES
    Publication number: 20180292410
    Abstract: The present disclosure relates to a method of detecting a relapse of a lung adenocarcinoma in an individual based on marker human epididymis protein 4 (HE4) and optionally Cytokeratin-19 fragments (Cyfra21-1) as well as the use of a marker in the in vitro assessment of a relapse of a lung adenocarcinoma.
    Type: Application
    Filed: June 14, 2018
    Publication date: October 11, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Farshid Dayyani, Friedemann Krause, Achim Escherich, Birgit Wehnl, Ying He, Vinzent Rolny, Sandra Rutz, Thomas Muley, Felix Herth, Julia Riedlinger
  • IGFBP7 FOR PREDICTION OF RISK OF AKI WHEN MEASURED PRIOR TO SURGERY
    Publication number: 20180231570
    Abstract: The present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) during or after a surgical procedure or after administration of a contrast medium. The method is based on the determination of the level of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) in a body fluid sample obtained from the patient prior to the surgical procedure or prior to the administration of a contrast medium. Further, the present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) based on the determination of the amount of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) and Cystatin C in a body fluid sample obtained from the patient. The present disclosure further encompasses kits and devices adapted to carry out the methods of the disclosed methods.
    Type: Application
    Filed: April 2, 2018
    Publication date: August 16, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Andrea Horsch, Birgit Klapperich, Dirk Block, Alfred Engel, Johann Karl, Rosemarie Kientsch-Engel, Ekaterina Manuilova, Christina Rabe, Sandra Rutz, Monika Soukupova, Ursula-Henrike Wienhues-Thelen, Peter Kastner, Edelgard Anna Kaiser
  • L-FABP BASED DIAGNOSIS OF KIDNEY INJURY AFTER AN ACUTE EVENT OR AFTER A SURGICAL INTERVENTION
    Publication number: 20160245827
    Abstract: Systems and methods for diagnosing acute kidney injury following an acute event or surgical intervention, based on assessing the biomarker L-FABP. Also, systems and methods for predicting the risk of an individual to suffer from a kidney injury after an acute event or surgical intervention in the future.
    Type: Application
    Filed: May 2, 2016
    Publication date: August 25, 2016
    Inventors: Hendrik Huedig, Rosemarie Kientsch-Engel, Sandra Rutz
  • L-FABP BASED DIAGNOSIS OF KIDNEY INJURY AFTER AN ACUTE EVENT OR AFTER A SURGICAL INTERVENTION
    Publication number: 20140187652
    Abstract: Systems and methods for diagnosing acute kidney injury following an acute event or surgical intervention, based on assessing the biomarker L-FABP. Also, systems and methods for predicting the risk of an individual to suffer from a kidney injury after an acute event or surgical intervention in the future.
    Type: Application
    Filed: March 4, 2014
    Publication date: July 3, 2014
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Hendrik Heudig, Rosemarie Kientsch-Engel, Sandra Rutz