Patents by Inventor Sandra Wathlet

Sandra Wathlet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Marker genes for oocyte competence
    Patent number: 11566289
    Abstract: Cumulus cell (CC) gene expression is being explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the biomarker genes identified using the methods of the present invention.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: January 31, 2023
    Assignee: Vrije Universiteit Brussel
    Inventors: Johan Smitz, Sandra Wathlet, Tom Adriaenssens
  • MARKER GENES FOR OOCYTE COMPETENCE
    Publication number: 20180327841
    Abstract: Cumulus cell (CC) gene expression is being explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the biomarker genes identified using the methods of the present invention.
    Type: Application
    Filed: July 19, 2018
    Publication date: November 15, 2018
    Applicant: Vrije Universiteit Brussel
    Inventors: Johan Smitz, Sandra Wathlet, Tom Adriaenssens
  • Marker genes for oocyte competence
    Patent number: 10053733
    Abstract: Cumulus cell (CC) gene expression is being explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the biomarker genes identified using the methods of the present invention.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: August 21, 2018
    Assignee: Vrije Universiteit Brussel
    Inventors: Johan Smitz, Sandra Wathlet, Tom Adriaenssens
  • MARKER GENES FOR OOCYTE COMPETENCE
    Publication number: 20160017422
    Abstract: Cumulus cell (CC) gene expression is being explored as an additional method to morphological scoring to choose the embryo with the highest chance to pregnancy. The present invention relates to a novel method of identifying biomarker genes for evaluating the competence of a mammalian oocyte in giving rise to a viable pregnancy after fertilization, based on the use of live birth and embryonic development as endpoint criteria for the oocytes to be used in an exon level analysis of potential biomarker genes. The invention further provides CC-expressed biomarker genes thus identified, as well as prognostic models based on the bio-marker genes identified using the methods of the present invention.
    Type: Application
    Filed: February 18, 2014
    Publication date: January 21, 2016
    Applicant: Vrije Universiteit Brussel
    Inventors: Johan Smitz, Sandra Wathlet, Tom Adriaenssens