Patents by Inventor Sandrien Janssens

Sandrien Janssens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation method for solid dispersions
    Patent number: 8216495
    Abstract: A method of preparation of a solid dispersion of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR with a BCS Class II drug or a BCS Class IV drug, whereby the method comprises: a) dissolving the polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer) separately in a water/first alcohol mixture; and b) dissolving the BCS Class II drug or a BCS Class IV drug, in a mixture of a second alcohol with a non alcoholic organic solvent in which the compound has an high solubility; and c) mixing the both solutions to obtain a third solution with a total amount of solved solid of 1 to 15 g per 100 ml, and optionally having an acid, including inorganic acids including hydrohalic acids, e.g.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: July 10, 2012
    Assignee: Formac Pharmaceuticals N.V.
    Inventors: Sandrien Janssens, Guy Van Den Mooter
  • ENHANCING SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE DRUGS
    Publication number: 20110059175
    Abstract: The present invention relates generally to use of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR, in the formulation of solid dispersions of low aqueous solubility and dissolution rate bioactive compound and, more particularly to a system and method for improving the solubility and dissolution rate of such low aqueous solubility and dissolution rate bioactive compound, in particular the drug of low aqueous solubility, such as a BCS Class II or Class IV drug compounds.
    Type: Application
    Filed: April 10, 2007
    Publication date: March 10, 2011
    Applicant: K.U.LEUVEN RESEARCH AND DEVELOPMENT
    Inventors: Sandrien Janssens, Guy Van Den Mooter
  • PREPARATION METHOD FOR SOLID DISPERSIONS
    Publication number: 20110018154
    Abstract: A method of preparation of a solid dispersion of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR with a BCS Class II drug or a BCS Class IV drug, whereby the method comprises: a) dissolving the polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer) separately in a water/first alcohol mixture; and b) dissolving the BCS Class II drug or a BCS Class IV drug, in a mixture of a second alcohol with a non alcoholic organic solvent in which the compound has an high solubility; and c) mixing the both solutions to obtain a third solution with a total amount of solved solid of 1 to 15 g per 100 ml, and optionally having an acid, including inorganic acids including hydrohalic acids, e.g.
    Type: Application
    Filed: March 25, 2009
    Publication date: January 27, 2011
    Applicant: FORMAC Pharmaceuticals N.V.
    Inventors: Sandrien Janssens, Guy Van Den Mooter
  • ENHANCING SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE DRUGS
    Publication number: 20090311325
    Abstract: The present invention relates generally to use of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR, in the formulation of solid dispersions of low aqueous solubility and dissolution rate bioactive compound and, more particularly to a system and method for improving the solubility and dissolution rate of such low aqueous solubility and dissolution rate bioactive compound, in particular the drug of low aqueous solubility, such as a BCS Class II or Class IV drug compounds.
    Type: Application
    Filed: April 10, 2007
    Publication date: December 17, 2009
    Applicant: K.U.LEUVEN RESEARCH AND DEVELOPMENT
    Inventors: Sandrien Janssens, Guy Van Den Mooter