Patents by Inventor Sandrine Picaud

Sandrine Picaud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-invasive real-time in vivo bioluminescence imaging of local CaÂ2+ dynamics in living organisms
    Patent number: 8263821
    Abstract: The invention relates to a method for optical detection of the dynamics of Ca2+ in a biological system, said method comprising monitoring the photons emitted by a recombinant Ca2+-sensitive polypeptide, which comprises or consists of a chemiluminescent protein linked to a fluorescent protein, present in said biological system. In a particular embodiment, said recombinant polypeptide comprises or consists of the Aequorin and GFP linked by a linker allowing chemiluminescence resonance energy transfer (CRET), and optionally comprises a peptidic fragment capable of targeting said recombinant polypeptide into a specific cellular domain or compartment. The present invention also concerns a transgenic non-human animal expressing said recombinant polypeptide sensitive to calcium concentration, in conditions enabling the in vivo monitoring of Ca2+ dynamics.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: September 11, 2012
    Assignee: Institut Pasteur
    Inventors: Philippe Brulet, Kelly Rogers, Sandrine Picaud
  • Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms
    Publication number: 20070274923
    Abstract: The invention relates to a method for optical detection of the dynamics of Ca2+ in a biological system, said method comprising monitoring the photons emitted by a recombinant Ca2+-sensitive polypeptide, which comprises or consists of a chemiluminescent protein linked to a fluorescent protein, present in said biological system. In a particular embodiment, said recombinant polypeptide comprises or consists of the Aequorin and GFP linked by a linker allowing chemiluminescence resonance energy transfer (CRET), and optionally comprises a peptidic fragment capable of targeting said recombinant polypeptide into a specific cellular domain or compartment. The present invention also concerns a transgenic non-human animal expressing said recombinant polypeptide sensitive to calcium concentration, in conditions enabling the in vivo monitoring of Ca2+ dynamics.
    Type: Application
    Filed: August 4, 2006
    Publication date: November 29, 2007
    Inventors: Philippe Brulet, Kelly Rogers, Sandrine Picaud
  • Non-invasive real-time in vivo bioluminescence imaging of local Ca²+ dynamics in living organisms
    Publication number: 20050273867
    Abstract: The invention relates to a method for optical detection of the dynamics of Ca2+ in a biological system, said method comprising monitoring the photons emitted by a recombinant Ca2+-sensitive polypeptide, which comprises or consists of a chemiluminescent protein linked to a fluorescent protein, present in said biological system. In a particular embodiment, said recombinant polypeptide comprises or consists of the Aequorin and GFP linked by a linker allowing chemiluminescence resonance energy transfer (CRET), and optionally comprises a peptidic fragment capable of targeting said recombinant polypeptide into a specific cellular domain or compartment. The present invention also concerns a transgenic non-human animal expressing said recombinant polypeptide sensitive to calcium concentration, in conditions enabling the in vivo monitoring of Ca2+ dynamics.
    Type: Application
    Filed: January 11, 2005
    Publication date: December 8, 2005
    Inventors: Philippe Brulet, Kelly Rogers, Sandrine Picaud