Abstract: Systems and methods for tracking sympathetic-driven arousal state (SDAS) including nociception under anesthesia is described herein. The method includes obtaining heart rate variability and electrodermal activity of a subject. Point process models are generated for the heart rate variability and the electrodermal activity. A multimodal approach is implemented to determine a state space framework based on these point process models. SDAS can be estimated using the state space framework. In some implementations, an anesthesiologist can modify the dosage of drugs administered to the subject based on this estimation.

Abstract: A device may obtain triaxial accelerometer training data for a plurality of subjects. A device may define a number of feature vectors for each time interval and each subject of the triaxial accelerometer data. A device may cluster the feature vectors of the triaxial training data into a number of clusters to obtain a cluster assignment for each of the feature vectors of each subject. A device may fit a hidden Markov model to the to the triaxial accelerometer training data cluster assignments. A device may identify at least one state for the subjects based on the cluster assignments.

Abstract: Systems and methods for identifying and removing artifacts from electrodermal activity (EDA) data are described herein. A method includes identifying artifacts in segments of EDA data using unsupervised machine learning based on feature vectors extracted from segments of the data. After the artifacts are identified, they can be removed from the EDA data. Artifact-free EDA data can be used to estimate a patient's nociceptive state, which in turn can be used to modify a dosage of anesthetic drugs administered to the patient based on this estimation.

Abstract: Systems and methods for tracking sympathetic-driven arousal state (SDAS) including nociception under anesthesia is described herein. The method includes obtaining heart rate variability and electrodermal activity of a subject. Point process models are generated for the heart rate variability and the electrodermal activity. A multimodal approach is implemented to determine a state space framework based on these point process models. SDAS can be estimated using the state space framework. In some implementations, an anesthesiologist can modify the dosage of drugs administered to the subject based on this estimation.

Abstract: A method and system for improving the effectiveness of cardioversion and defibrillation through the ability to reduce transthoracic impedance. A method and system of decreasing transthoracic impedance that allows standardized pressure to be applied directly over desired defibrillator patches. This system reduces transthoracic impedance by increasing effective pressure on desired patches through use of a manual depressor device which incorporates a deformable patient body interface and mechanical and or electronic mechanisms to provide qualitative and or quantitative feedback on the force being applied to said patches. By depressing the device over desired external adhesive electrode patches until an audio and or visual signal indicates sufficient applied pressure, increased patch to skin contact is achieved to decrease the effective transthoracic impedance of a patient upon delivery of a defibrillation shock.

Abstract: A method and system improves the effectiveness of cardioversion or defibrillation through the ability to switch shock vectors and to reduce transthoracic impedance. An external multiple patch system comprises at least two options for a shocking vector once external patches are applied and adhered to desired locations on a patient's body. A manual switching mechanism in the system provides the ability to direct current from a defibrillator to either of two or more adhesive electrode patches. A method and system of decreasing transthoracic impedance comprises wrapping material around a patient's body to apply pressure to adhered patches, which further reduces transthoracic impedance by increasing effective pressure on the patches through use of pressure-focusing mechanisms located between a patch and a strap.

Abstract: A method of identifying an epileptogenic zone of a subject's brain includes receiving a plurality of electrical signals from a corresponding plurality of surgically implanted electrodes, calculating a first plurality of connectivities between each pair of electrodes based on a portion of each of the plurality of electrical signals corresponding to a first time period, assigning a rank corresponding to each electrode for the first period of time based on the first plurality of connectivities to provide a first plurality of ranks, calculating a second plurality of connectivities between each pair of electrodes based on a portion of each of the plurality of electrical signals corresponding to a second time period, assigning a rank corresponding to each electrode for the second period of time based on the second plurality of connectivities to provide a second plurality of ranks, identifying a cluster of electrodes among the plurality of electrodes based on relative changes between the first plurality of ranks fro

Abstract: A method and system for an improved wearable defibrillator specifically optimized for patient comfort and compliance. The system is capable of sensing information about the patient, determining whether the patient is experiencing a life-threatening arrhythmia, and if so, deliver life-saving defibrillation. The system is specifically designed, constructed, and configured to allow for minimal weight on the shoulders and its associated lumbar spine compression when standing and minimal pressure on the abdomen or thorax when supine in order to increase patient comfort and compliance. This configuration and design can be implemented in several forms including but not limited to the material(s) used, the placement of various components, the durability of the components, the operative or communicative connection between various components, the efficiency and/or accuracy of the various components in performing their functions, and/or the maintenance procedure.

Abstract: A method and system for improving the effectiveness of cardioversion and defibrillation through the ability to reduce transthoracic impedance. A method and system of decreasing transthoracic impedance that allows standardized pressure to be applied directly over desired defibrillator patches. This system reduces transthoracic impedance by increasing effective pressure on desired patches through use of a manual depressor device which incorporates a deformable patient body interface and mechanical and or electronic mechanisms to provide qualitative and or quantitative feedback on the force being applied to said patches. By depressing the device over desired external adhesive electrode patches until an audio and or visual signal indicates sufficient applied pressure, increased patch to skin contact is achieved to decrease the effective transthoracic impedance of a patient upon delivery of a defibrillation shock.

Abstract: A method and system for improving the effectiveness of cardioversion or defibrillation through the ability to switch shock vectors and to reduce transthoracic impedance. A “shock vector” or “shocking vector” is herein defined as the path and direction which electrical current follows in traversing a patient body cavity between two external adhesive electrode patches. An external multiple patch system comprises at least two options for a shocking vector once external patches are applied and adhered to desired locations on a patient's body. A manual switching mechanism in the system provides the ability to direct current from a defibrillator to either of two or more specified shocking vectors. A method and system of decreasing transthoracic impedance comprises wrapping material around a patient's body to apply pressure to adhered patches.

Abstract: A method of identifying an epileptogenic zone of a subject's brain includes receiving a plurality of electrical signals from a corresponding plurality of surgically implanted electrodes, calculating a first plurality of connectivities between each pair of electrodes based on a portion of each of the plurality of electrical signals corresponding to a first time period, assigning a rank corresponding to each electrode for the first period of time based on the first plurality of connectivities to provide a first plurality of ranks, calculating a second plurality of connectivities between each pair of electrodes based on a portion of each of the plurality of electrical signals corresponding to a second time period, assigning a rank corresponding to each electrode for the second period of time based on the second plurality of connectivities to provide a second plurality of ranks, identifying a cluster of electrodes among the plurality of electrodes based on relative changes between the first plurality of ranks fro