Abstract: The present invention relates to splice modulating oligonucleotides (oligomers) that are complementary to the CARD9 pre-mRNA, for inhibiting the inclusion of a CARD9 exon 11 in CARD9 mRNA. The oligonucleotides of the invention are useful in the treatment of inflammatory diseases such as IBD.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to CARD9 pre-mRNA intron and exon sequences, which are capable of inhibiting the expression of CARD9 protein. Inhibition of CARD9 expression is beneficial for a range of medical disorders including inflammatory bowel disease, pancreatitis, IgA nephropathy, primary sclerosing cholangitis, cardiovascular disease, cancer and diabetes.

Abstract: A piezoelectric microvalve employs a valve element formed of hermetically sealed and opposed plates flexed together by a cross axis piezoelectric element. Large flow modulation with small piezoelectric actuator displacement is obtained by perimeter augmentation of the valve seat which dramatically increases the change in valve flow area for small deflections.

Abstract: A piezoelectric microvalve employs a valve element formed of hermetically sealed and opposed plates flexed together by a cross axis piezoelectric element. Large flow modulation with small piezoelectric actuator displacement is obtained by perimeter augmentation of the valve seat which dramatically increases the change in valve flow area for small deflections.

Abstract: A controller for heating, ventilating and air-conditioning distribution systems, which includes feedforward and feedback control strategies. The controller has a feedforward control strategy that generates a control signal based on control set points and identified characteristics of the system, and which adaptively adjusts such set points based on changes that are measured with respect to the identified characteristics. The controller is particularly adapted for controlling the temperature during a heating or cooling operation in a controlled space.

Abstract: A controller for heating, ventilating and air-conditioning distribution systems, which includes a feedforward and feedback control strategies. The controller has a feedforward control strategy that generates a control signal based on control set points and identified characteristics of the system, and which adaptively adjusts such set points based on changes that are measured with respect to the identified characteristics. The controller is particularly adapted for controlling the differential air pressure in a controlled space relative to adjacent spaces.

Abstract: A controller implemented in a heating, ventilation and air-conditioning (HVAC) distribution system provides improved control by implementing a general regression neural network to generate a control signal based on identified characteristics of components utilized within the HVAC system. The general regression neural network utilizes past characteristics and desired (calculated) characteristics to generate an output control signal. The general regression neural network is implemented in a feedforward process, which is combined with a feedback process to generate an improved control signal to control components within the HVAC distribution system. Implementation of the general regression neural network is simple and accurate, requires no input from an operator supervising the controller, and provides adaptive, real-time control of components within the HVAC distribution system.