Patents by Inventor Sanford Markowitz

Sanford Markowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Device for collecting a biological sample
    Patent number: 12376837
    Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: August 5, 2025
    Assignee: Case Western Reserve University
    Inventors: Sanford Markowitz, Amitabh Chak, Joseph Willis, Jeffrey Silver Taggart, Rebecca Blice, Dean Secrest, Dennis Siedlak
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20250243217
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 23, 2024
    Publication date: July 31, 2025
    Inventors: Sanford Markowitz, Joseph Ready, Yongyou Zhang, Monika Antczak, James K.V. Willson, Bruce Posner, William Greenlee
  • Compositions and methods of modulating short-chain dehydrogenase activity
    Patent number: 12336982
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: June 24, 2025
    Assignees: Rodeo Therapeutics Corporation, Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, Joseph Ready, Stephen L. Gwaltney, II, Monika Antczak
  • Device for Biological Cell Collection and Method of Use
    Publication number: 20250195050
    Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.
    Type: Application
    Filed: February 27, 2025
    Publication date: June 19, 2025
    Applicant: Case Western Reserve University
    Inventors: Amitabh Chak, Sanford Markowitz, Dennis Siedlak, Joseph Willis, Lishan Aklog, Michael Boutillette, Richard Yazbeck
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20250161277
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Inventors: Sanford Markowitz, Joseph Ready, Stephen L. Gwaltney, II, Monika Antczak
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS
    Publication number: 20250134868
    Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
    Type: Application
    Filed: October 3, 2024
    Publication date: May 1, 2025
    Inventors: Sanford Markowitz, Amar Desai, Joseph Ready
  • Device for biological cell collection and method of use
    Patent number: 12262879
    Abstract: A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: April 1, 2025
    Assignee: Case Western Reserve University
    Inventors: Amitabh Chak, Sanford Markowitz, Dennis Siedlak, Joseph Willis, Lishan Aklog, Michael Boutillette, Richard Yazbeck
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20240174688
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 30, 2024
    Inventors: Sanford Markowitz, Joseph Ready, Yongyou Zhang, Monika Antczak, James K.V. Willson, Bruce Posner, William Greenlee
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH
    Publication number: 20240100026
    Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: May 11, 2023
    Publication date: March 28, 2024
    Inventors: Sanford MARKOWITZ, Joseph READY, Andrew PIEPER
  • METHODS OF DETECTING HIGH RISK BARRETT'S ESOPHAGUS WITH DYSPLASIA, AND ESOPHAGEAL ADENOCARCINOMA
    Publication number: 20240068033
    Abstract: A method of detecting Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus, applying a Repetitive Element Aneuploidy Sequencing System (RealSeqS) methodology to a biological sample from the esophagus of the subject to detect Barrett's esophagus with low grade dysplasia, or Barrett's esophagus with high grade dysplasia, or adenocarcinoma of the esophagus.
    Type: Application
    Filed: January 14, 2022
    Publication date: February 29, 2024
    Inventors: Sanford Markowitz, Amitabh Chak, Helen Moinova, Joseph Willis, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettewgowda, Christopher Douville
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20240043440
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: November 21, 2022
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, Monika Antczak, Joseph Ready, Yongyou Zhang
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20240043443
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monica Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • COMPOSITIONS AND METHODS FOR TREATING RENAL INJURY
    Publication number: 20240024297
    Abstract: A method for preventing or treating renal ischemia reperfusion injury or acute kidney injury associated with renal ischemia reperfusion injury in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: March 29, 2023
    Publication date: January 25, 2024
    Inventors: Sanford Markowitz, Ki Beom Bae, Hye Jung Kim, Sun-Hee Kim
  • COMBINATIONS OF 15-PGDH INHIBITORS WITH CORTICOSTEROIDS AND/OR TNF INHIBITORS AND USES THEREOF
    Publication number: 20230355636
    Abstract: A method of treating intestinal, gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.
    Type: Application
    Filed: May 5, 2023
    Publication date: November 9, 2023
    Inventors: Sanford Markowitz, Won Jin Ho, Stephen P. Fink, Vinay Varadan
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE
    Publication number: 20230322684
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: June 9, 2023
    Publication date: October 12, 2023
    Inventors: Sanford Markowitz, Yiyuan Yuan, Yongyou Zhang, Joseph Ready, Bin Hu
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING NEURODEGENERATION
    Publication number: 20230310390
    Abstract: A method of treating neurodegeneration and/or neurodegenerative condition, disease, or disorder caused by and/or associated with elevated or aberrant 15-PGDH activity in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: August 9, 2021
    Publication date: October 5, 2023
    Inventors: Sanford Markowitz, Andrew Pieper, Hongyun Li, Edwin Vazquez Rosa, Min-Kyoo Shin, Yeojung Koh, Joseph Ready
  • Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
    Publication number: 20230285402
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 14, 2023
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • Compositions and methods of modulating short-chain dehydrogenase
    Patent number: 11718589
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: August 8, 2023
    Assignees: Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, Yiyuan Yuan, Yongyou Zhang, Joseph Ready, Bin Hu
  • Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof
    Patent number: 11690847
    Abstract: A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: July 4, 2023
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Sanford Markowitz, Won Jin Ho, Stephen P. Fink, Vinay Varadan
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230192717
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 22, 2023
    Inventors: Stephen L Gwaltney, Joseph Ready, Monika Antczak, Sanford Markowitz, Amar Desai, Stanton Gerson