Patents by Inventor Sang Hoon YUN

Sang Hoon YUN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING RECOMBINANT HYALURONIDASE
    Publication number: 20250136964
    Abstract: Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.
    Type: Application
    Filed: November 7, 2024
    Publication date: May 1, 2025
    Applicant: ALTEOGEN Inc.
    Inventors: Soon Jae PARK, Kyuwan KIM, Sang Hoon YUN, Jeong Soo CHO, Kibum PARK, Minsoo BYUN, Hyung-Nam SONG, Ji-Sun KIM, Ki Seok NAM
  • METHOD FOR PRODUCING RECOMBINANT HYALURONIDASE
    Publication number: 20250129352
    Abstract: Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.
    Type: Application
    Filed: November 7, 2024
    Publication date: April 24, 2025
    Applicant: ALTEOGEN Inc.
    Inventors: Soon Jae PARK, Kyuwan KIM, Sang Hoon YUN, Jeong Soo CHO, Kibum PARK, Minsoo BYUN, Hyung-Nam SONG, Ji-Sun KIM, Ki Seok NAM
  • N-terminal and/or C-terminal Cleaved Soluble PH20 Polypeptide and Use Thereof
    Publication number: 20250122492
    Abstract: The present disclosure relates to a recombinant PH20 polypeptide in which 1 to 7 amino acid residues are deleted at the N-terminus of a mature animal wild-type PH20, and use thereof. The N-terminal and/or C-terminal cleaved PH20 polypeptide with improved enzymatic activity and productivity presented in the present disclosure may exhibit superior expression and enzymatic activity compared to conventional recombinant PH20 polypeptides, which may result in reduced production costs for industrial use and thus reduced treatment costs.
    Type: Application
    Filed: June 21, 2023
    Publication date: April 17, 2025
    Inventors: Soon Jae PARK, Kyuwan KIM, Sang Hoon YUN, Hyung-Nam SONG
  • Method for producing recombinant hyaluronidase
    Patent number: 12221638
    Abstract: Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: February 11, 2025
    Assignee: ALTEOGEN Inc.
    Inventors: Soon Jae Park, Kyuwan Kim, Sang Hoon Yun, Jeong Soo Cho, Kibum Park, Minsoo Byun, Hyung-Nam Song, Ji-Sun Kim, Ki Seok Nam
  • Growth hormone receptor antagonists and fusion proteins thereof
    Patent number: 11981719
    Abstract: The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: May 14, 2024
    Assignee: Alteogen, Inc.
    Inventors: Soon Jae Park, Jaehyeong Ko, Sun-Ah You, Sang Hoon Yun
  • METHOD FOR PRODUCING RECOMBINANT HYALURONIDASE
    Publication number: 20230174963
    Abstract: Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.
    Type: Application
    Filed: August 6, 2021
    Publication date: June 8, 2023
    Inventors: Soon Jae PARK, Kyuwan KIM, Sang Hoon YUN, Jeong Soo CHO, Kibum PARK, Minsoo BYUN, Hyung Nam SONG, Ji-Sun KIM, Ki Seok NAM
  • NOVEL GROWTH HORMONE RECEPTOR ANTAGONIST AND FUSION PROTEIN THEREOF
    Publication number: 20200399340
    Abstract: The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.
    Type: Application
    Filed: December 20, 2018
    Publication date: December 24, 2020
    Inventors: Soon Jae PARK, Jaehyeong KO, Sun-Ah YOU, Sang Hoon YUN