Abstract: The present invention relates to a pharmaceutical composition comprising trimebutine as an active ingredient for prevention or treatment of cancer. Having an excellent effect of selectively inhibiting growth and proliferation of cancer stem cells, the pharmaceutical composition can suppress the recurrence, metastasis, and progression of cancer even when used alone. Thus, the composition can be advantageously used as a pharmaceutical composition for prevention or treatment of cancer or in combination with other agents.

Abstract: The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient.

Abstract: The present invention relates to a compound comprising an EZH2 inhibitor and an E3 ligase binder, and a pharmaceutical composition for preventing or treating EZH2-associated disease and a pharmaceutical composition for selective protein degradation containing the same as an active ingredient. Since the compound of the present invention can selectively degrade EZH2, it can be effectively used for the treatment of EZH2-related diseases and cancers, particularly, cancers in which EZH2 is overexpressed, and can be usefully used for the selective degradation of EZH2.

Abstract: A composition according to an embodiment of the present disclosure includes a N-phenyl-methylsulfonamido-acetamide compound represented by Formula 1. The composition may inhibit osteoclast differentiation and/or formation and exhibit excellent prophylactic or therapeutic effects on various bone diseases including periodontitis and the like. A method for treating a bone disease caused by hyperdifferentiation of osteoclasts according to an embodiment of the present disclosure includes administering to a subject in need thereof the composition.

Abstract: A composition according to an embodiment of the present disclosure includes a compound represented by Formula 1. The composition may inhibit osteoclast differentiation and/or formation and exhibit excellent prophylactic or therapeutic effects on various bone diseases including periodontitis and the like. A method for treating a bone disease caused by hyperdifferentiation of osteoclasts according to an embodiment of the present disclosure includes administering to a subject in need thereof the composition.

Abstract: The present invention relates to a pharmaceutical composition comprising trimebutine as an active ingredient for prevention or treatment of cancer. Having an excellent effect of selectively inhibiting growth and proliferation of cancer stem cells, the pharmaceutical composition can suppress the recurrence, metastasis, and progression of cancer even when used alone. Thus, the composition can be advantageously used as a pharmaceutical composition for prevention or treatment of cancer or in combination with other agents.

Abstract: Provided is a 2-cyanopyrimidin-4-yl carbamate or urea derivative or pharmaceutically acceptable salt thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 2-cyanopyrimidin-4-yl carbamate or urea derivative or pharmaceutically acceptable salt thereof selectively inhibits cathepsin K and therefore can be usefully applied for preventing or treating osteoporosis.

Abstract: A position detecting device for detecting a position of a magnet configured to move over a first target point and a second target point in steps includes a first hall device configured to generate a first hall voltage, a second hall device configured to generate a second hall voltage, a subtractor configured to generate a subtraction voltage based on a difference between the first hall voltage and the second hall voltage, an adder configured to generate an addition voltage based on a combination of the first hall voltage and the second hall voltage, a divider configured to calculate a ratio of the subtraction voltage to the addition voltage, and a subtraction voltage changing unit configured to maintain the subtraction voltage at the first target point and the second target point and in a transition section between the first target point and the second target point to be constant.

Abstract: A novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or inflammatory diseases, containing the same as an active ingredient are provided. The novel organic sulfur compound is capable of excellently inhibiting histone deacetylated (HDAC) enzymes in a concentration of nanomolar or micromolar units and has been found to have an excellent effect against inflammatory diseases, and has been found to be capable of inhibiting the proliferation of cancer.

Abstract: A novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or inflammatory diseases, containing the same as an active ingredient are provided. The novel organic sulfur compound is capable of excellently inhibiting histone deacetylated (HDAC) enzymes in a concentration of nanomolar or micromolar units and has been found to have an excellent effect against inflammatory diseases, and has been found to be capable of inhibiting the proliferation of cancer.

Abstract: A controller of a camera iris is provided. The controller includes a signal processing circuit that generates a detected position value corresponding to a current position of the iris, based on first and second sensing signals respectively received from first and second position sensors that detects an aperture position of the iris; a control circuit, that sets a section between the first aperture position and the second aperture position to a plurality of control sections, and if a command to change the aperture of the iris is made, performing a corresponding control operation for each of the plurality of control sections to control a movement operation of the iris, based on the detected position value; and a driving circuit that generates a driving current, and provide the generates driving current to a coil to drive the iris under control of the controller.

Abstract: A position detecting device for detecting a position of a magnet configured to move over a first target point and a second target point in steps includes a first hall device configured to generate a first hall voltage, a second hall device configured to generate a second hall voltage, a subtractor configured to generate a subtraction voltage based on a difference between the first hall voltage and the second hall voltage, an adder configured to generate an addition voltage based on a combination of the first hall voltage and the second hall voltage, a divider configured to calculate a ratio of the subtraction voltage to the addition voltage, and a subtraction voltage changing unit configured to maintain the subtraction voltage at the first target point and the second target point and in a transition section between the first target point and the second target point to be constant.

Abstract: Provided is a 2-cyanopyrimidin-4-yl carbamate or urea derivative or pharmaceutically acceptable salt thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 2-cyanopyrimidin-4-yl carbamate or urea derivative or pharmaceutically acceptable salt thereof selectively inhibits cathepsin K and therefore can be usefully applied for preventing or treating osteoporosis.

Abstract: An actuator of a camera module includes a detected portion disposed on a lens barrel, and a position detector including a first sensing coil and a second sensing coil, disposed to face the detected portion, and a reference coil disposed outside of a region facing the detected portion, wherein the position detector detects a position of the detected portion in accordance with calculation results of inductances of the first sensing coil and the second sensing coil, and removes noise components by applying inductance of the reference coil to the calculation results of inductances of the first sensing coil and the second sensing coil.

Abstract: The present invention relates to a novel imidazopyridine derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof and a pharmaceutically acceptable salt thereof can effectively inhibit cancer-related kinases, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer.

Abstract: An actuator includes an oscillating unit including two or more oscillation circuits each configured to output an oscillation signal including a frequency, which is changed in response to movement of a detection target, a frequency down-converting unit configured to down-convert frequencies of two or more oscillation signals respectively output from the two or more oscillation circuits, and a determining unit configured to calculate a position of the detection target in response to two or more down-converted oscillation signals output from the frequency down-converting unit.

Abstract: An actuator for a camera module includes two or more detectable elements, the detectable elements are respectively disposed on a first and second surface of a lens barrel, an oscillating element including a first oscillation circuit unit that includes two or more oscillation circuits facing the first surface of the lens barrel, and a second oscillation circuit unit that includes two or more oscillation circuits facing the second surface of the lens barrel, and a determining device that calculates a position of the lens barrel in response to oscillation signals output from the oscillating element. The determining device is configured to calculate the position of the lens barrel based on determined frequencies of oscillation signals of the first oscillation circuit unit and the second oscillation circuit unit.

Abstract: An actuator of a camera module includes a detected portion disposed on a lens barrel, and a position detector including a first sensing coil and a second sensing coil, disposed to face the detected portion, and a reference coil disposed outside of a region facing the detected portion, wherein the position detector detects a position of the detected portion in accordance with calculation results of inductances of the first sensing coil and the second sensing coil, and removes noise components by applying inductance of the reference coil to the calculation results of inductances of the first sensing coil and the second sensing coil.

Abstract: An actuator including a detection target disposed on a surface of a lens barrel, and a position detecting unit including two or more sensing coils and configured to detect a displacement of the detection target in a first direction perpendicular to an optical axis, wherein when the detection target moves in a second direction perpendicular to the optical axis, an area of overlap between each of the two or more sensing coils and the detection target is maintained constant.

Abstract: A wireless power transmitter includes a sampling controller setting different retrieval sampling points of time for each section, among candidate sampling points of time, in each section of a carrier frequency signal; and a sampling unit configured to sample points of the carrier frequency signal at the different retrieval sampling points of time. The sampling controller compares values sampled by the sampling unit with each other, and determines a determined sampling point based on a comparison result.