Abstract: The present invention relates to a method for obtaining a compound, after removing at least a portion of insoluble substances or macromolecules from a fermentation broth, by performing one or more of the following steps (a) to (c), and recovering a desired compound: (a) increasing the concentration of a desired compound in the fermentation broth; (b) reducing the concentration of a residual carbon source or alcohol in the fermentation broth; and (c) reducing the concentration of ionic components in the fermentation broth.

Abstract: In a method and a system for decolorizing and deodorizing a polyhydric alcohol according to embodiments of the present invention, a mixture liquid containing a first polyhydric alcohol obtained by a separation process is prepared. The mixture liquid is subjected to a distillation treatment to preliminarily remove substances with different colors and odors to generate a pre-treatment liquid. The pre-treatment liquid is subjected to an adsorption treatment. Through a combination of the distillation treatment and the adsorption treatment, the removing efficiency of the substances with different colors and odors can be increased.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: A method for treating an inflammatory disease, a skin disease or a skin wrinkle according to an embodiment of the present invention includes administering or applying a composition including 1,2-butandediol to a subject in need thereof. The composition including-butanediol may be used as an anti-inflammatory, anti-oxidative or anti-wrinkle active ingredient. 2,3-butanediol can be used as an active ingredient of a pharmaceutical or cosmetic composition.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: In a method and a system for decolorizing and deodorizing a polyhydric alcohol according to embodiments of the present invention, a mixture liquid containing a first polyhydric alcohol obtained by a separation process is prepared. The mixture liquid is subjected to a distillation treatment to preliminarily remove substances with different colors and odors to generate a pre-treatment liquid. The pre-treatment liquid is subjected to an adsorption treatment. Through a combination of the distillation treatment and the adsorption treatment, the removing efficiency of the substances with different colors and odors can be increased.

Abstract: A method for creating a site on a user terminal connected by a computer network to a site management system includes providing a plurality of cards having predefined functions to the user terminal; and creating a site including at least one of a page corresponding to a card selected at the user terminal by a user from among the plurality of cards and a page including, as a component, at least one card selected at the terminal. The plurality of cards includes a general card configured through a selection and a combination of components by the user and a function card of which a function and a structure are predetermined.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: The present invention relates to an apparatus and a method for fermenting, separating, and refining a product, which is produced by cultivating a microorganism. The apparatus and the method for fermenting, separating, and refining, of the present invention, can separate and refine the product that is produced by microbial fermentation in a simple, continuous manner and with high efficiency.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: A search service providing apparatus including a memory configured to store computer-readable instructions, and one or more processors configured to execute the instructions to receive a search request including input data from a user terminal, the input data including a keyword, generate a search result in response to the input data, the search result including a keyword-related advertisement and a route code corresponding to the keyword-related advertisement, transmit the search result to the user terminal, monitor a user event with regard to the route code, and determine fees to be charged on the keyword-related advertisement, based on the user event may be provided.

Abstract: A method for creating a site on a user terminal connected by a computer network to a site management system includes providing a plurality of cards having predefined functions to the user terminal; and creating a site including at least one of a page corresponding to a card selected at the user terminal by a user from among the plurality of cards and a page including, as a component, at least one card selected at the terminal. The plurality of cards includes a general card configured through a selection and a combination of components by the user and a function card of which a function and a structure are predetermined.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: The present invention relates to an apparatus and a method for fermenting, separating, and refining a product, which is produced by cultivating a microorganism. The apparatus and the method for fermenting, separating, and refining, of the present invention, can separate and refine the product that is produced by microbial fermentation in a simple, continuous manner and with high efficiency.

Abstract: The present invention relates to an apparatus and a method for fermenting, separating, and refining a product, which is produced by cultivating a microorganism. The apparatus and the method for fermenting, separating, and refining, of the present invention, can separate and refine the product that is produced by microbial fermentation in a simple, continuous manner and with high efficiency.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Abstract: This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.