Abstract: The present invention pertains to a composition having a protective effect during islet transplantation, and more specifically, to a composition containing a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof, and capable of providing a protective effect against oxidative stress, inflammation, etc. during islet transplantation.

Abstract: The present disclosure relates to a cell implant for islet grafts and uses thereof. More specifically, the present disclosure provides a method for treating or preventing diabetes including administering a composition comprising a spheroid and an islet cluster as active ingredients to a subject in need thereof, and a method for preparing the cell implant. According to the present disclosure, the cell implant can reduce loss of the biological activity and function of islet cells and increase the viability of the islet cells. Therefore, the cell implant can improve the quality of the islet cells or maintain the quality for a long time and also improve angiogenic capacity, and, thus, can be used in treating diabetes.