Abstract: A tooth whitener is provided, including a water-in-oil (W/O) emulsion phase including: a discontinuous phase comprising a peroxide, a hydrophilic solvent, and a polyol, and a continuous phase comprising a glycerol monooleate, a polymer and a polyol, wherein the tooth whitener is flowable upon being applied to teeth and is solidified by the action of moisture after being applied to teeth, and then is adhered and fixed to teeth, and wherein the glycerol monooleate is in an amount of 15% to 95% by weight, based on total weight of the tooth whitener composition.

Abstract: Disclosed herein is an oral care composition that provides pleasant cooling sensation and easy delivery of an oral care active ingredient. The tablet-type oral care composition of the present invention is prepared by compressing porous plastic granules at a pressure of 500 kg/cm2 or less and undergoes in situ melting and gelling by saliva or water in the buccal cavity, or by chewing. Upon direct administration of the composition to the buccal cavity, the composition undergoes melting and gelling by water or saliva, or by chewing action, and works to maintain oral health via gargling or mouth washing. Therefore, the formulation of the present invention advantageously reduces inconvenience of conventional liquid or ointment-like oral care products and also provides easy portability.

Abstract: Disclosed herein is a breath freshener whose phase is changed depending on the condition of use. A breath freshener of W/O emulsion phase comprises a monoglyceride as a main base, a polymer, an effective component for breath freshening, and a solvent. A breath freshener of solution phase comprises a monoglyceride as a main base, a polyol, a polymer, an effective component for breath freshening, and a solvent. Since the breath fresheners are sufficiently flowable to spray when being sprayed into the oral cavity, they are easy to use. In addition, the breath fresheners are phase-changed into a cubic phase by moisture, e.g., saliva, after being sprayed into the oral cavity, resulting in an increase in the viscosity and adhesiveness of the breath fresheners. Therefore, the effective breath freshening ingredient is slowly released from the breath fresheners, and as a result, continuous breath freshening effects are achieved.

Abstract: Disclosed herein is a tooth whitener using glycerol monooleate. The tooth whitener is a composition that exhibits teeth whitening effects when being applied to teeth. Specifically, the tooth whitener comprises a glycerol monooleate, a polyol, a polymer, a peroxide and a hydrophilic solvent, and has a W/O emulsion phase. The tooth whitener is flowable before being applied to teeth and is spreadable when being applied to teeth. In addition, the tooth whitener is solidified by the action of moisture, such as saliva, after being applied to teeth, and can thus be adhered and fixed to the teeth. Further-more, changes in viscosity of the tooth whitener with varying temperature can he minimized and the release rate of the whitening ingredient can he controlled by the addition of polyol.

Abstract: Disclosed is an oral composition effective against halitosis comprising an extract from Moutan (Paeonia suffruticosa Andrews) bark as an active ingredient, which is capable of inhibiting and eliminating substances causing oral malodor. The oral composition of the invention compromises an extract from Moutan bark, a medicinal herb, as an active ingredient, formulated in conjunction with to a conventional oral composition, thereby providing long lasting and powerful eliminating and preventive effects against halitosis.

Abstract: Disclosed is composition for enhancing oral health, which includes 0.0001˜10 wt % of Xanthorrhizol on the basis of the total weight of the composition, and 0.01˜10 wt % of at least one antibacterial activity enhancer selected form the group consisting of alkyl sodium sulfate, sodium lauroyl sarcocinate and sodium methylcocoyltaurate. The antibacterial activity enhancer contained in the composition more effectively enhances antibacterial activity of Xanthorrhizol against causative bacterial of a decayed tooth or a peridental disease existing in the mouth, so the composition is very helpful for enhancing the oral health, for example the prevention or relief of a decayed tooth or a peridental disease or the restraint of foul breath.

Abstract: The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent comprising a cyclosporin A derivative in which sarcosine is substituted with thiosarcosine in the 3-position as an active ingredient.

Abstract: The present invention discloses a topical scalp and transdermal preparation with excellent penetration to the skin and follicle, containing a [?-hydroxy-N-methyl-L-leucine4] cylosporin derivative which is a non-immunosuppressive component with hair growth stimulating ability. The topical scalp and transdermal preparation is prepared by incorporating the cyclosporin derivative into a liposome, microcapsule, micro-sphere, composite particle or emulsion, capable of being employed as a hair growth stimulating agent and applied for the prevention of hair loss.

Abstract: Disclosed is an oral composition effective against halitosis comprising an extract from Moutan (Paeonia suffruticosa Andrews) bark as an active ingredient, which is capable of inhibiting and eliminating substances causing oral malodor.

Abstract: The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent comprising a cyclosporin A derivative substituted in the 3-position as an active ingredient.

Abstract: The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative having an excellent hair growth stimulating ability with little immunosuppressive effect as an active ingredient. In accordance with the invention, there is provided a hair growth promoting agent comprising a cyclosporin derivative represented by Chemical Formula 1 below. The derivatives of the invention were prepared by derivatization of cyclosporins at the amino acid residue 4, N-methyl-L-leucine, and hair growth promoting effects thereof were examined. Such a hair growth promoting agent, comprising a cyclosporin derivative as an active ingredient, exhibits an excellent hair growth effect, while it shows very weak immunosuppressive activity, compared to unmodified cyclosporin A.

Abstract: Disclosed is a hair growth promoting agent including a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent including a cyclosporin A derivative substituted in the 3-position as an active ingredient.

Abstract: The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent comprising a cyclosporin A derivative in which sarcosine is substituted with thiosarcosine in the 3-position as an active ingredient.

Abstract: The present invention discloses a composition comprising a cyclosporin derivative having an excellent hair revitalizing activity as an active ingredient, and more particularly, a composition comprising cyclosporin 7-thioamide produced by chemical derivatization of cyclosporin as an active ingredient for promoting hair growth.

Abstract: The present invention discloses a composition comprising a cyclosporin A derivative having an excellent hair revitalizing activity as an active ingredient, and more particularly, a composition comprising cyclosporin A 7-thioamide produced by chemical derivatization of cyclosporin A as an active ingredient for promoting hair growth.

Abstract: The present invention discloses a topical composition for prevention and alleviation of wrinkling which comprises one or two or more selected from the group consisting of Phenytoin, Valproic acid, Cyclosporin A, Nifedipine, Diltiazem, Verapamil HCl and Amoldipine as an active ingredient having an effect of boosting collagen synthesis.

Abstract: Disclosed is a hair growth promoting agent including a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent including a cyclosporin A derivative substituted in the 3-position as an active ingredient.

Abstract: The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent comprising a cyclosporin A derivative substituted in the 3-position as an active ingredient.

Abstract: The present invention relates to methods for treating alopecia and stimulating hair growth and pharmaceutical compositions using nonimmunosuppressive [&ggr;-hydroxy-methylleucine4] cyclosporin A having superior hair growth-promoting effect, wherein the hydroxyl group is added to the carbon position of No. 4 methylleucine of cyclosporin A by the microorganism.

Abstract: The present invention discloses a hair growth promoter comprising [&ggr;-hydroxy-N-methyl-L-leucine9] cyclosporin A, in which a hydroxy group is added to a &ggr; carbon of N-methyl-L-leucine at No. 9 position in cyclosporin A by metabolic action of a microorganism, as an active ingredient.