Abstract: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

Abstract: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

Abstract: Asymmetrical dendritic compound of the Formula (I) as described herein can contain multiple functional moieties as represented by R1 and R2 in Formula (I). In various embodiments, the functional moieties include N-Boc, a targeting ligand, a drug, and/or an imaging agent. A number of such functionalized asymmetrical dendritic compounds can be used for various therapies, including cancer treatment.

Abstract: Asymmetrical dendritic compound of the Formula (I) as described herein can contain multiple functional moieties as represented by R1 and R2 in Formula (I). In various embodiments, the functional moieties include N-Boc, a targeting ligand, a drug, and/or an imaging agent. A number of such functionalized asymmetrical dendritic compounds can be used for various therapies, including cancer treatment.

Abstract: A television on a chip (TVOC) system that provides a cost effective approach for providing television functionality on a single integrated circuit chip is disclosed. A TVOC includes the functionality necessary to receive and display television signals in a variety of input and output formats. A TVOC can be used in set-top boxes for cable and satellite television, or directly within a television. All functionality provided can be provided on a single integrated circuit. TVOC includes a data transport module, an IF demodulator, a digital audio engine, an analog audio engine, a digital video engine, and an analog video engine. The TVOC also includes three sets of interfaces including output interfaces, control interfaces and ancillary interfaces. Further features and embodiments provide enhanced functionality and increased efficiencies.

Abstract: Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.

Abstract: Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.

Abstract: Agents and methods for imaging a cell and/or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and/or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and/or diagnosis a condition or disease.

Abstract: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Abstract: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Abstract: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.

Abstract: Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.

Abstract: A television on a chip (TVOC) system that provides a cost effective approach for providing television functionality on a single integrated circuit chip is disclosed. A TVOC includes the functionality necessary to receive and display television signals in a variety of input and output formats. A TVOC can be used in set-top boxes for cable and satellite television, or directly within a television. All functionality provided can be provided on a single integrated circuit. TVOC includes a data transport module, an IF demodulator, a digital audio engine, an analog audio engine, a digital video engine, and an analog video engine. The TVOC also includes three sets of interfaces including output interfaces, control interfaces and ancillary interfaces. Further features and embodiments provide enhanced functionality and increased efficiencies.

Abstract: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Abstract: Among other things, a computer-implemented method for annotating webpage content includes accessing a webpage in a browser, the webpage under control of a third party. A collection of annotations stored at a storage location is retrieved, the annotations collection associated with the webpage and an annotations author. The webpage is displayed with the retrieved annotations collection overlaid on the accessed webpage.

Abstract: Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.

Abstract: Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.

Abstract: Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.

Abstract: Polymers that can include an end-cap selected from Formula (I) and/or Formula (II) and a recurring unit of the Formulae (III), and/or (IV). The polymers can include various substituents such as drug, targeting agents, stabilizing agents, imaging agent and polydentate ligands. Such polymer can be useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.

Abstract: Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.