Patents by Inventor Sang Yeob Park
Sang Yeob Park has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11839684Abstract: Disclosed is a mucoadhesive pharmaceutical composition comprising a poly-ionic complex of chitosan and a polyacrylic acid polymer. As an oral formulation, the composition has the extended retention time in the gastrointestinal tract by its mucoadhesive and swelling properties, which is useful as sustained release formulations, retentive formulations of active ingredients with limited absorption regions, and active ingredients with pH dependent solubility.Type: GrantFiled: July 29, 2021Date of Patent: December 12, 2023Assignee: SAMYANG HOLDINGS CORPORATIONInventors: Sang Yeob Park, Jong Won Yoon
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Publication number: 20210353530Abstract: Disclosed is a mucoadhesive pharmaceutical composition comprising a poly-ionic complex of chitosan and a polyacrylic acid polymer. As an oral formulation, the composition has the extended retention time in the gastrointestinal tract by its mucoadhesive and swelling properties, which is useful as sustained release formulations, retentive formulations of active ingredients with limited absorption regions, and active ingredients with pH dependent solubility.Type: ApplicationFiled: July 29, 2021Publication date: November 18, 2021Applicant: SAMYANG HOLDINGS CORPORATIONInventors: Sang Yeob Park, Jong Won Yoon
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Patent number: 11077099Abstract: The present disclosure relates to an oral tablet composition comprising lenalidomide and a method for preparing the same. More particularly, the present disclosure relates to a tablet-type composition and a method for preparing the same wherein the composition exhibits physicochemical equivalence with lenalidomide preparations of hard capsules, has the same pharmacological, therapeutic effect in non-clinical studies and bioequivalence studies, and also has improved ease of taking, handling, safety and the like.Type: GrantFiled: September 11, 2017Date of Patent: August 3, 2021Assignee: SAMYANG HOLDINGS CORPORATIONInventors: Sang Yeob Park, Hye Jung Lim, Sa Won Lee, Min Hyo Seo
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Publication number: 20200261426Abstract: Disclosed are an oral solid dosage form composition comprising an active ingredient and a solubilizing carrier wherein a foaming ingredient is used to improve disintegration, dispersion or dissolution, and a preparation method therefor.Type: ApplicationFiled: October 30, 2018Publication date: August 20, 2020Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Sang Yeob PARK, Hye Jung LIM, Jae Young LEE, Min Hyo SEO, Sa Won LEE
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Publication number: 20200078463Abstract: Disclosed are: a composition having improved water solubility and bioavailability, containing sorafenib and a polymethacrylate copolymer; and a preparation method therefor.Type: ApplicationFiled: April 30, 2018Publication date: March 12, 2020Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Sang Yeob PARK, Hye Jung LIM, Sa Won LEE, Min Hyo SEO
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Publication number: 20200038390Abstract: The present disclosure relates to an oral tablet composition comprising lenalidomide and a method for preparing the same. More particularly, the present disclosure relates to a tablet-type composition and a method for preparing the same wherein the composition exhibits physicochemical equivalence with lenalidomide preparations of hard capsules, has the same pharmacological, therapeutic effect in non-clinical studies and bioequivalence studies, and also has improved ease of taking, handling, safety and the like.Type: ApplicationFiled: September 11, 2017Publication date: February 6, 2020Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Sang Yeob PARK, Hye Jung LIM, Sa Won LEE, Min Hyo SEO
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Publication number: 20190021985Abstract: Disclosed is a mucoadhesive pharmaceutical composition comprising a poly-ionic complex of chitosan and a polyacrylic acid polymer. As an oral formulation, the composition has the extended retention time in the gastrointestinal tract by its mucoadhesive and swelling properties, which is useful as sustained release formulations, retentive formulations of active ingredients with limited absorption regions, and active ingredients with pH dependent solubility.Type: ApplicationFiled: December 29, 2016Publication date: January 24, 2019Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Sang Yeob PARK, Jong Won YOON
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Melt-extruded release controlled pharmaceutical composition and oral dosage form comprising the same
Patent number: 10143659Abstract: Disclosed are a controlled release pharmaceutical composition, comprising a melt-extruded pellet including a water-insoluble ammonium methacrylate copolymer, a polyvinyl acetate, and an active ingredient; and a polymer coating layer including a water-insoluble ammonium methacrylate copolymer formed on the surface of the pellet, and an oral formulation including the pharmaceutical composition.Type: GrantFiled: December 20, 2013Date of Patent: December 4, 2018Assignee: Samyang Biopharmaceutical CorporationInventors: Sang-Yeob Park, Hye-Jung Lim, Kyung-Hee Kim -
Patent number: 9526789Abstract: Disclosed are an oral formulation which disintegrates quickly in the oral cavity; a fast-disintegrating tablet having fast disintegrability and high hardness, and a process for manufacturing the same. In addition, slightly wetted granules for manufacturing said fast-disintegrating tablet and a process for manufacturing the same are disclosed.Type: GrantFiled: December 28, 2012Date of Patent: December 27, 2016Assignee: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Sang Yeob Park, Hye Jung Lim
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Melt-Extruded Release Controlled Pharmaceutical Composition and Oral Dosage Form Comprising the Same
Publication number: 20160213621Abstract: Disclosed are a controlled release pharmaceutical composition, comprising a melt-extruded pellet including a water-insoluble ammonium methacrylate copolymer, a polyvinyl acetate, and an active ingredient; and a polymer coating layer including a water-insoluble ammonium methacrylate copolymer formed on the surface of the pellet, and an oral formulation including the pharmaceutical composition.Type: ApplicationFiled: December 20, 2013Publication date: July 28, 2016Inventors: Sang-Yeob Park, Hye-Jung Lim, Kyung-Hee Kim -
Publication number: 20160199302Abstract: Disclosed are dry granules comprising temozolomide and tartaric acid as a pH stabilizer, a pharmaceutical composition including the dry granules with improved stability and a method of preparing the same.Type: ApplicationFiled: December 20, 2013Publication date: July 14, 2016Inventors: Hye-Jung Lim, Sang-yeob Park, Kyung-Hee Kim
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Publication number: 20150086623Abstract: A controlled-release pharmaceutical composition including first and second groups of microparticles, each of the microparticles including a core including tamsulosin or pharmaceutically acceptable salts thereof, a controlled-release polymer coating layer formed on the core, and an enteric polymer outer layer formed on the controlled-release polymer coating layer, wherein the average thickness of the controlled-release polymer coating layer is different in each of the first and second groups of microparticles, and an oral formulation including the same, are provided. This pharmaceutical composition can easily control the extent of release of an active ingredient depending on changes in pH in the intestinal tract and the release pattern of the active ingredient in the small intestine, thus preventing the active ingredient from being rapidly transferred into the blood to thereby minimize side-effects, and maintaining the effective blood concentration of the active ingredient for a predetermined period of time.Type: ApplicationFiled: December 1, 2014Publication date: March 26, 2015Inventors: Ho-Jin Chung, Sang-Yeob Park, Chaul-Min Pai
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Publication number: 20140364513Abstract: Disclosed are an oral formulation which disintegrates quickly in the oral cavity; a fast-disintegrating tablet having fast disintegrability and high hardness, and a process for manufacturing the same. In addition, slightly wetted granules for manufacturing said fast-disintegrating tablet and a process for manufacturing the same are disclosed.Type: ApplicationFiled: December 28, 2012Publication date: December 11, 2014Inventors: Sang Yeob Park, Hye Jung Lim
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Patent number: 8465768Abstract: Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the release pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc.Type: GrantFiled: November 6, 2009Date of Patent: June 18, 2013Assignee: Samyang Biopharmaceuticals CorporationInventors: Sang Yeob Park, Hojin Chung, Chaul Min Pai
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Publication number: 20130052264Abstract: A controlled-release pharmaceutical composition including first and second groups of microparticles, each of the microparticles including a core including tamsulosin or pharmaceutically acceptable salts thereof, a controlled-release polymer coating layer formed on the core, and an enteric polymer outer layer formed on the controlled-release polymer coating layer, wherein the average thickness of the controlled-release polymer coating layer is different in each of the first and second groups of microparticles, and an oral formulation including the same, are provided. This pharmaceutical composition can easily control the extent of release of an active ingredient depending on changes in pH in the intestinal tract and the release pattern of the active ingredient in the small intestine, thus preventing the active ingredient from being rapidly transferred into the blood to thereby minimize side-effects, and maintaining the effective blood concentration of the active ingredient for a predetermined period of time.Type: ApplicationFiled: April 27, 2011Publication date: February 28, 2013Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Ho-Jin Chung, Sang-Yeob Park, Chaul-Min Pai
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Publication number: 20110223247Abstract: Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the release pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc.Type: ApplicationFiled: November 6, 2009Publication date: September 15, 2011Applicant: SAMYANG CORPORATIONInventors: Sang Yeob Park, Hojin Chung, Chaul Min Pai
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Patent number: 7749533Abstract: A fast-melting pharmaceutical tablet comprises a porous, plastic substance, a water penetration enhancer and a binder. One or more drugs can be incorporated into the formulation at different stages of the process so as to afford a pharmaceutically active tablet. Methods of making the pharmaceutical tablet entail combining the porous, plastic material, the water penetration enhancing agent, and the binder so as to form highly plastic granules, which are compressed into tablets. The resulting tablets dissolve rapidly in the mouth and have good hardness with low brittleness. The tablets are particularly valuable to those who have difficulty swallowing conventional pills.Type: GrantFiled: May 7, 2004Date of Patent: July 6, 2010Assignee: Akina, Inc.Inventors: Yourong Fu, Chaul Min Pai, Sang Yeob Park, Gun Seomoon, Kinam Park
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Publication number: 20060134195Abstract: Fast-dissolving pharmaceutical tablets comprising mannose are described. The mannose component imparts both structure-forming and fast-dissolution properties to the tablets. Granulation of tablet components and humidification forms strong liquid bridges at the surface interfaces of mannose particles, which leads to strengthened tablets. The mannose particles, however, remain porous following compression so that contact with moisture, e.g., saliva in the mouth, leads rapidly to tablet disintegration and dissolution.Type: ApplicationFiled: November 25, 2003Publication date: June 22, 2006Inventors: Yourong Fu, Seong Jeong, Jeanny Kim, Jacqueline Callihan, Kinam Park, Chaul Pai, Sang Yeob Park, Gun Seomoon
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Patent number: 6103865Abstract: There are disclosed pH-sensitive polymers containing sulfonamide groups, which can be changed in physical properties, such as swellability and solubility, depending on pH and which can be applied for a drug-delivery system, bio-material, sensor, etc, and a preparation method therefor. The pH-sensitive polymers are prepared by introduction of sulfonamide groups, various in pKa, to hydrophilic groups of polymers either through coupling to the hydrophilic groups, such as acrylamide, N,N-dimethylacrylamide, acrylic acid, N-isopropylacrylamide, etc, of polymers or copolymerization with other polymerizable monomers. These pH-sensitive polymers may have a structure of linear polymer, grafted copolymer, hydrogel or interpenetrating network polymer.Type: GrantFiled: December 22, 1998Date of Patent: August 15, 2000Assignee: Kwangju Institute of Science and TechnologyInventors: You Han Bae, Sang Yeob Park