Abstract: The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor.

Abstract: The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor.

Abstract: A toothbrush includes a head having a proximal end and a distal end furthest from the proximal end. The head also includes a top face having a plurality of bristle tufts disposed therein, a back face opposed to the top face, and a tip. An elastomeric support element covers a portion of the back face, and the tip is uncovered by the elastomeric support element. A first plurality of elastomeric elements is integrally formed with the elastomeric support element. Each of the first plurality of elastomeric elements extends individually from the elastomeric support element and terminates in a free end.

Abstract: A toothbrush includes a head having a proximal end and a distal end furthest from the proximal end. The head also includes a top face having a plurality of bristle tufts disposed therein, a back face opposed to the top face, and a tip. An elastomeric support element covers a portion of the back face, and the tip is uncovered by the elastomeric support element. A first plurality of elastomeric elements is integrally formed with the elastomeric support element. Each of the first plurality of elastomeric elements extends individually from the elastomeric support element and terminates in a free end.

Abstract: A toothbrush includes a head having a proximal end and a distal end furthest from the proximal end. The head also includes a top face having a plurality of bristle tufts disposed therein, a back face opposed to the top face, and a tip. An elastomeric support element covers a portion of the back face, and the tip is uncovered by the elastomeric support element. A first plurality of elastomeric elements is integrally formed with the elastomeric support element. Each of the first plurality of elastomeric elements extends individually from the elastomeric support element and terminates in a free end.

Abstract: The toothbrush of the present invention comprises an elongated handle having a head attached to one end. The head has a bristle-bearing face having longitudinal perimeter portions adjacent longitudinal edges and at least two perimetric, elastomeric massaging elements alternately arranged with groups of bristle tufts along each of the longitudinal perimeter portions. The brush can comprise further massaging elements which are not located along the longitudinal perimeter portions though the use of such additional elements is preferably minimized. The perimetric massaging elements have rotational symmetry through an angle of 120° or less, preferably being circular. The cross-sectional area proportion of elastomeric massaging elements to bristles on the brush head is less than 25%.

Abstract: The toothbrush of the present invention comprises an elongated handle having a head attached to one end. The head has a bristle-bearing face having longitudinal perimeter portions adjacent longitudinal edges and at least two perimetric, elastomeric massaging elements alternately arranged with groups of bristle tufts along each of the longitudinal perimeter portions. The brush can comprise further massaging elements which are not located along the longitudinal perimeter portions though the use of such additional elements is preferably minimised. The perimetric massaging elements have rotational symmetry through an angle of 120° or less, preferably being circular. The cross-sectional area proportion of elastomeric massaging elements to bristles on the brush head is less than 25%. Alternately there are four or fewer elastomeric massaging elements which are not perimetric massaging elements.

Abstract: A toothbrush having a handle and, attached at one end thereof, a head (1), the head (1) having a handle end (4), a free end (2), and a bristle-bearing face (7) with a plurality of tufts (6) extending therefrom, the tufts (6) each having a base and a free end and comprising one or more bristles, wherein the tufts (6) are arranged in groups which are separated from each other by a transverse gap (8), the distance between the bases of the tufts (6) within a group being less than 1.3 mm, the distance between the bases of the tufts (6) between groups being in the range from 1.3 mm to 5 mm and wherein the distance between the free ends of the tufts between groups is preferably at least 0.5 mm. Preferably, each group is in the form of a crescent shaped array and tufts (6) are generally perpendicular to the toothbrush head (1).

Abstract: A toothbrush having a handle (4) and a head (1), the head (1) being of length L and having longitudinal and transverse axes, the head (1) having a bristle-bearing surface (7) with a plurality of tufts (6) extending therefrom, wherein the tufts (6) are arranged in a plurality of groups N, which are separated from each other by a transverse gap (8) of from 1.3 mm to 5 mm, the distance between tufts (6) within a group being less than 1.3 mm, and wherein at least 50% of the tufts (6) are characterized by there being no other tuft (6) within 1.3 mm, measured along a line parallel to the transverse axis, for at least 50% of the width of the tuft (6). Preferably, each group is in the form of a crescent shaped array and tufts (6) are generally perpendicular to the toothbrush head (1). The arrangement allows for independent movement of bristle tufts (6), particularly whilst using the Bass technique for toothbrushing, yet maintains a high density of tufts (6) on the toothbrush head (1).