Patents by Inventor Sanjay F. Thakor

Sanjay F. Thakor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphs of ponatinib hydrochloride
    Patent number: 10221184
    Abstract: Novel crystalline ponatinib hydrochloride forms designated Form alpha and Form beta are disclosed. Form alpha is characterized by data selected from an XRPD pattern with peaks at about 6.5, 9.0, 12.25, 14.4, 16.70, 19.6, 22.2, 24.5, 28.2±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 1; and/or a combination thereof. Form beta is characterized by data selected from an XRPD pattern with peaks at about 10.7, 15.2, 15.8, 16.4 23.1, 25.0, 27.8±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 3; and/or combinations thereof. Processes for making Form alpha and Form beta are disclosed.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: March 5, 2019
    Assignee: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Ananda Babu Thirunavakarasu, Gaurav Yadav, Veerabhadra Rao Bobbili, Shivnath Sahebrao Patil, Sanjay F. Thakor
  • Novel polymorphs of ponatinib hydrochloride
    Publication number: 20180208599
    Abstract: Novel crystalline ponatinib hydrochloride forms designated Form alpha and Form beta are disclosed. Form alpha is characterized by data selected from an XRPD pattern with peaks at about 6.5, 9.0, 12.25, 14.4, 16.70, 19.6, 22.2, 24.5, 28.2±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 1; and/or a combination thereof. Form beta is characterized by data selected from an XRPD pattern with peaks at about 10.7,15.2, 15.8, 16.4 23.1, 25.0, 27.8±0.2 degrees 2-theta; an XRPD pattern substantially as depicted in FIG. 3; and/or combinations thereof. Processes for making Form alpha and Form beta are disclosed.
    Type: Application
    Filed: January 4, 2018
    Publication date: July 26, 2018
    Applicant: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Ananda Babu Thirunavakarasu, Gaurav Yadav, Veerabhadra Rao Bobbili, Shivnath Sahebrao Patil, Sanjay F. Thakor
  • Processes for making ponatinib and intermediates thereof
    Patent number: 9988389
    Abstract: Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 5, 2018
    Assignee: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik, Dhakhada Chetana Bharatbhai, Khichi Kuldip Fatehlal, Shivnath Sahebrao Patil
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20180044345
    Abstract: Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 15, 2018
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik, Dhakhada Chetana Bharatbhai, Khichi Kuldip Fatehlal, Shivnath Sahebrao Patil
  • METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF
    Publication number: 20170008848
    Abstract: Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally safe and cost effective. The methods may employ inexpensive starting materials and the preparation processes for intermediates are simple and highly reproducible. Novel intermediates for the preparation of netupitant and pharmaceutically acceptable salts thereof are also disclosed. Amorphous netupitant and methods of making same are disclosed.
    Type: Application
    Filed: September 23, 2016
    Publication date: January 12, 2017
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik
  • METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF
    Publication number: 20160368875
    Abstract: Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally safe and cost effective. The methods may employ inexpensive starting materials and the preparation processes for intermediates are simple and highly reproducible. Novel intermediates for the preparation of netupitant and pharmaceutically acceptable salts thereof are also disclosed. Amorphous netupitant and methods of making same are disclosed.
    Type: Application
    Filed: September 6, 2016
    Publication date: December 22, 2016
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20160362411
    Abstract: Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 15, 2016
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik, Dhakhada Chetana Bharatbhai, Khichi Kuldip Fatehlal, Shivnath Sahebrao Patil
  • Processes for making ponatinib and intermediates thereof
    Patent number: 9493473
    Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: November 15, 2016
    Assignee: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Rajesh A Patel
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20160108053
    Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.
    Type: Application
    Filed: December 30, 2015
    Publication date: April 21, 2016
    Applicant: Apicore US LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Rajesh A. Patel
  • METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF
    Publication number: 20150315149
    Abstract: Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally safe and cost effective. The methods may employ inexpensive starting materials and the preparation processes for intermediates are simple and highly reproducible. Novel intermediates for the preparation of netupitant and pharmaceutically acceptable salts thereof are also disclosed. Amorphous netupitant and methods of making same are disclosed.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Ashish Naik
  • PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF
    Publication number: 20140343282
    Abstract: Novel synthetic approaches to make 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof are provided.
    Type: Application
    Filed: May 16, 2014
    Publication date: November 20, 2014
    Applicant: Apicore, LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannapan, Sanjay F. Thakor, Rajesh A Patel
  • Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
    Patent number: 8748631
    Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: June 10, 2014
    Assignee: Apicore, LLC
    Inventors: Ravishanker Kovi, KeshavRao Rapole, Ashish Naik, Jayaraman Kannapan, Murali Krishna Madala, Sanjay F. Thakor
  • PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
    Publication number: 20130023671
    Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
    Type: Application
    Filed: May 24, 2012
    Publication date: January 24, 2013
    Applicant: APICORE, LLC
    Inventors: Ravishanker Kovi, KeshavRao Rapole, Ashish Naik, Jayaraman Kannapan, Murali Krishna Madala, Sanjay F. Thakor