Abstract: Provided herein are thin film compositions and methods of making thin films comprising lactic acid (e.g. L-lactic acid), a water-soluble polymer, and a plasticizer. The thin films may be used for contraception and/or in preventing transmission of sexually transmitted infections.

Abstract: A computer-implemented method is provided for designing a processing path to process a part from a workpiece by a material processing system. The method includes receiving a template point cloud for a reference workpiece and a template processing path for processing a reference part from the reference workpiece. The method also includes generating a workpiece point cloud comprising a set of spatial points defining the workpiece and aligning the workpiece point cloud with the template point cloud to determine a spatial mapping between the workpiece and the reference workpiece and between the part on the workpiece and the reference part on the reference workpiece. The method further includes producing a robotic program tailored to the workpiece that includes a processing path about the part on the workpiece that is generated based on the template processing path and the spatial mapping.

Abstract: A method of treating and/or preventing gastric ulcers, said method comprising administering by injection a therapeutically effective amount of a composition comprising: c) a first agent selected from the group consisting of: a medium chain triglyceride and a long chain triglyceride; and d) a second agent comprising a proton pump inhibitor or pharmaceutically or veterinary acceptable salt, wherein the composition is adapted for sustained release of a therapeutically effective amount of the proton pump inhibitor to a subject in need thereof.

Abstract: A double nozzle for a laser processing head includes an inner body portion having an interior surface defining a bore for passing a laser beam, a first interface surface near a distal end of the inner body portion, the first interface surface including a plurality of channels, and an exterior surface near a proximal end of the inner body portion and shaped to engage the laser processing head. Each channel includes interior and exterior linear edges in a cross-section that passes though a central longitudinal axis of the double nozzle. The double nozzle also includes an outer body portion connected to the inner body portion. The outer body portion defines a jet surface, which together with the plurality of channels defines a corresponding plurality of auxiliary fluid flow paths about the bore and between the inner body portion and the outer body portion.

Abstract: A double nozzle for a laser processing head includes an inner body portion having an interior surface defining a bore for passing a laser beam, a first interface surface near a distal end of the inner body portion, the first interface surface including a plurality of channels, and an exterior surface near a proximal end of the inner body portion and shaped to engage the laser processing head. Each channel includes interior and exterior linear edges in a cross-section that passes though a central longitudinal axis of the double nozzle. The double nozzle also includes an outer body portion connected to the inner body portion. The outer body portion defines a jet surface, which together with the plurality of channels defines a corresponding plurality of auxiliary fluid flow paths about the bore and between the inner body portion and the outer body portion.

Abstract: The invention relates to formulations of tryptamines and monoamine oxidase inhibitors and uses thereof in methods of treatment. In particular, compositions having a modified-release of a tryptamine and an immediate release of a monoamine oxidase inhibitor. Also disclosed are methods of treating disorders with tryptamines in combination with monoamine oxidase inhibitors.

Abstract: An additive supply apparatus for a high-pressure liquid jet system is provided. The additive supply apparatus includes a processing head having a central bore extending along a central longitudinal axis of the processing head from a proximal end to a distal end. The additive supply apparatus also includes a first aperture fluidly connected to the central bore to supply a fluid jet to flow longitudinally within the processing head, a second aperture fluidly connected to the central bore to supply a flow of gas to the processing head, and a third aperture fluidly connected to the central bore to supply a flow of an additive fluid to the processing head. The additive supply apparatus further includes a fluid mixing insert disposed within the central bore and fluidly connected to the first, second and third apertures, and a mixing tube in fluid communication with and downstream from the fluid mixing insert.

Abstract: A double nozzle for a laser processing head includes an inner body portion having an interior surface defining a bore for passing a laser beam, a first interface surface near a distal end of the inner body portion, the first interface surface including a plurality of channels, and an exterior surface near a proximal end of the inner body portion and shaped to engage the laser processing head. Each channel includes interior and exterior linear edges in a cross-section that passes though a central longitudinal axis of the double nozzle. The double nozzle also includes an outer body portion connected to the inner body portion. The outer body portion defines a jet surface, which together with the plurality of channels defines a corresponding plurality of auxiliary fluid flow paths about the bore and between the inner body portion and the outer body portion.

Abstract: A high-pressure liquid jet cutting system can include a hopper configured to contain an abrasive mixture that includes abrasive and an additive, and a cutting head configured to receive the abrasive mixture from the hopper and introduce the abrasive mixture into a high-pressure liquid jet. The system can further include a sensor configured to detect a characteristic of the abrasive mixture associated with the additive, and one or more processors operably connected to the sensor and configured to determine information about the abrasive based, at least in part, on the detected characteristic. The one or more processors can be configured to adjust or otherwise control operation of one or more components of the high-pressure liquid jet cutting system based, at least in part, on the information to, e.g., improve or optimize system performance.

Abstract: A double nozzle for a laser processing head includes an inner body portion having an interior surface defining a bore for passing a laser beam, a first interface surface near a distal end of the inner body portion, the first interface surface including a plurality of channels, and an exterior surface near a proximal end of the inner body portion and shaped to engage the laser processing head. Each channel includes interior and exterior linear edges in a cross-section that passes though a central longitudinal axis of the double nozzle. The double nozzle also includes an outer body portion connected to the inner body portion. The outer body portion defines a jet surface, which together with the plurality of channels defines a corresponding plurality of auxiliary fluid flow paths about the bore and between the inner body portion and the outer body portion.

Abstract: Provided herein are methods of treating or preventing a fungal colonisation or infection in a subject. The method includes administering a therapeutically effective amount of a compound, or a therapeutically acceptable salt thereof, to the subject, wherein the fungal colonisation or infection is caused by a fungal agent.

Abstract: The invention includes methods and compositions for treating mastitis in a subject. The method includes the step of administering, by intramammary delivery, a therapeutically effective amount of a polyether ionophore, or a therapeutically acceptable salt thereof, to the mammary gland of the subject.

Abstract: A method of treating and/or preventing gastric ulcers, said method comprising administering by injection a therapeutically effective amount of a composition comprising: c) a first agent selected from the group consisting of: a medium chain triglyceride and a long chain triglyceride; and d) a second agent comprising a proton pump inhibitor or pharmaceutically or veterinary acceptable salt, wherein the composition is adapted for sustained release of a therapeutically effective amount of the proton pump inhibitor to a subject in need thereof.

Abstract: A method of treating and/or preventing gastric ulcers, said method comprising administering by injection a therapeutically effective amount of a composition comprising: c) a first agent selected from the group consisting of: a medium chain triglyceride and a long chain triglyceride; and d) a second agent comprising a proton pump inhibitor or pharmaceutically or veterinary acceptable salt, wherein the composition is adapted for sustained release of a therapeutically effective amount of the proton pump inhibitor to a subject in need thereof.

Abstract: Disclosed is an Edaravone dosage form and a use thereof in preparing a drug used for treating diseases related to oxidative stress, the dosage form being selected from a lipid-based delivery system, a solid dispersion, micelles and a co-solvent based formulation.

Abstract: A double nozzle for a laser processing head includes an inner body portion having an interior surface defining a bore for passing a laser beam, a first interface surface near a distal end of the inner body portion, the first interface surface including a plurality of channels, and an exterior surface near a proximal end of the inner body portion and shaped to engage the laser processing head. Each channel includes interior and exterior linear edges in a cross-section that passes though a central longitudinal axis of the double nozzle. The double nozzle also includes an outer body portion connected to the inner body portion. The outer body portion defines a jet surface, which together with the plurality of channels defines a corresponding plurality of auxiliary fluid flow paths about the bore and between the inner body portion and the outer body portion.

Abstract: A system and method of analyzing an engine model is disclosed. The system and method include performing a Dynamic Systems Analysis on the engine model that includes modifying a transient allowance of the engine model to determine an optimal balance between performance and operability and assessing the conservatism level of the engine model.

Abstract: A double nozzle for a laser processing head includes an inner body portion having an interior surface defining a first bore, and an exterior surface, the bore aligned with a central longitudinal axis of the body. The double nozzle includes an outer body portion having an interior surface defining a second bore that is substantially aligned to the longitudinal axis. The outer body portion is matingly engaged with a region of the exterior surface of the inner body portion. The region between the exterior surface of the inner body portion and the interior surface of the outer body portion defines at least six coaxial fluid flow paths through an interior annular flow volume of the double nozzle. Each fluid flow path is defined at least in part by a corresponding feature formed in at least one of the inner body portion or the outer body portion.

Abstract: Variety of approaches to optimize a feature deployment based on an usage pattern are described. A hosted service initiates operations to optimize the feature deployment upon detecting a feature update associated with an application. Next, a target audience for the feature update is identified by processing an usage pattern signal of the application based on information update and an organizational rule associated with the feature update. The feature update is deployed to the target audience.

Abstract: The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.