Abstract: A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient's tumor; (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and 20 of the PIK3CA gene or which show loss of PTEN protein expression will be considered not likely to benefit from EGFR targeting therapies.

Abstract: A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient's tumor; (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and 20 of the PIK3CA gene or which show loss of PTEN protein expression will be considered not likely to benefit from EGFR targeting therapies.

Abstract: A capacitor (14) is disposed in, for example, a ferrite shell (12). A winding (20) is formed around the shell, thereby providing an inductive component. Additional windings may be provided to form a transformer. In combining the two components into a unitary package, a space savings is realized, and assembly efficiency is increased.

Abstract: An electrochemical capacitor chip device (10) includes a plurality of capacitor subassemblies (12, 14, 16, 18, 20, and 22) arranged in stacked configuration. Each stacked capacitor assembly shares a single common electrode (48) from which extends a contact tab. Attached to contact tabs are lead pins (26, 28, 30 and 32) for effecting electrical and mechanical communication with, for example, a printed circuit board. The capacitor subassemblies may be preferably fabricated of electrochemical capacitor subassemblies employing gelled polymeric electrolyte structures.

Abstract: An electrochemical cell (10) having a first electrode (20) and second electrode (80) and a separator (40) disposed therebetween further includes a layer of material disposed between at least one of the electrodes and the separator (52). The layer (52) is adapted to reduce the likelihood of cell failure by subduing the dendritic growth of at least one of the electrodes. The layer (52) is a layer of a metal mesh screen and may further be adapted to be used as the current collector for collecting current generated by the cell (10).