Abstract: Disclosed herein, are methods for treating, preventing or inhibiting a coronavirus infection or a disease or condition associated with a coronavirus infection. The methods can comprise administering to the subject one or more therapeutically effective doses of sulforaphane.

Abstract: A self-contained kit and method for the on-demand synthesis of 2-deoxy-2-[18F]fluoro-D-sorbitol (18F-FDS) from commercially available 2-deoxy-2-[18F]fluoroglucose (18F-FDG) is disclosed.

Abstract: The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. The labeled substrates can be used to determine whether a subject is infected with an infectious organism by imaging means, and with use of two or more such labeled substrates, methods of differentiating gram negative infection from gram positive infection, and methods of localizing and quantifying infectious disease burden are provided. The methods of the present invention can assist in the clinical decision to begin empiric antibiotic therapy, determine its efficacy, as well as the choice of antibacterial agents.

Abstract: The present invention provides positron emitter radiolabeled versions of PABA, metabolites and derivatives, with good radiochemical yield, high specific activity, high chemical and radiochemical purity and having excellent characteristics for PET imaging. The inventive composition and methods provide high quality dynamic images of the kidneys while reducing the radiation exposure. The short biological half-life of PABA, added to the short physical half-life of positron emitters such as 11C will also benefit patients that require multiple renography assessments in a short period of time.

Abstract: Vaccines comprising Mycobacterium tuberculosis (M. tuberculosis) PknD sensor polypeptides, compositions, kits, and methods of use for treating central nervous system tuberculosis are disclosed. More specifically, the disclosure provides a method for treating or preventing central nervous system (CNS) tuberculosis (TB) in a subject, the method comprises administering to the subject a therapeutically effective amount of a vaccine comprising an M tuberculosis PknD sensor polypeptide, or an immunogenic fragment for inhibiting or preventing M tuberculosis bacterial invasion of brain microvascular endothelia.

Abstract: The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. The labeled substrates can be used to determine whether a subject is infected with an infectious organism by imaging means, and with use of two or more such labeled substrates, methods of differentiating gram negative infection from gram positive infection, and methods of localizing and quantifying infectious disease burden are provided. The methods of the present invention can assist in the clinical decision to begin empiric antibiotic therapy, determine its efficacy, as well as the choice of antibacterial agents.

Abstract: A self laminating wristband separable from a multi-ply page form has a plurality of separated imaging areas, with one larger imaging area for receiving printed data corresponding to the wearer such as his name, i.d. number, etc., with one or more second imaging areas adapted to receive either printed information or markers which may be adhered thereto. The separated imaging areas are aligned along the length of the wristband so that the gap between them acts as a natural hinge point which allows the imaging areas to lie flatter against the wearer's wrist.

Abstract: A business form comprising a face ply and a lamination ply includes a matrix of self adhering labels positioned in a label area and a self laminating wristband positioned in a wristband area, all of which are defined by die cuts therein for removal upon use. The wristband is comprised of a left edge justified, reduced length imaging area releasably adhered to a laminating portion comprising a pair of laminating panels one of which is smaller sized to merely laminate the imaging area and with self adhering tabs at opposite ends of the panels. A wristband extender is die cut into the lamination ply within the profile of the wristband. A second embodiment includes a pair of separated imaging areas in the same space as the single imaging area along with special precautions labels die cut into the lamination ply for application to the second smaller imaging area. The wristband may be provided separately in an envelope sized sheetlet or in a page size form with multiple wristbands but no labels.

Abstract: A printer processible business form includes a separable wristband formed with a multi-layer, reinforced central panel or imaging area with a pair of straps extending to the sides thereof. The multi-ply wristband may be formed with a single die cut solely in the top ply of a two ply business form which is folded over after having been separated to thereby fashion the multi-ply print or image area. Alternatively, the multi-ply wristband may be formed with a first die cut in the top ply as before, but with a second die cut in a bottom or backer ply to form a backing or reinforcing panel which is adhered to the wristband and when separated thereby forms a multi-ply print area. In another alternative embodiment, the backer panel may be added to the first embodiment so that the panel or image area has three or even four layers of material to provide maximum reinforcement.

Abstract: A business form comprising a face ply and a lamination ply includes a matrix of self adhering labels positioned in a label area and a self laminating wristband positioned in a wristband area, all of which are defined by die cuts therein for removal upon use. The wristband is comprised of a left edge justified, reduced length imaging area releasably adhered to a laminating portion comprising a pair of laminating panels one of which is smaller sized to merely laminate the imaging area and with self adhering tabs at opposite ends of the panels. A wristband extender is die cut into the lamination ply within the profile of the wristband. A second embodiment includes a pair of separated imaging areas in the same space as the single imaging area along with special precautions labels die cut into the lamination ply for application to the second smaller imaging area. The wristband may be provided separately in an envelope sized sheetlet or in a page size form with multiple wristbands but no labels.

Abstract: A wrap around, self laminating wristband comprises a substantially transparent laminate strap with an imaging area for receiving printed information and one or more layers of adhesive adjacent the imaging area so that as the strap is wrapped around itself to overlie the imaging area it laminates it. Alternate embodiments provide for a snap closure to secure the wristband instead of adhesive, forming the imaging area with a coating of a thermally sensitive or active print material, adding one or more labels for common use with the wristband, forming the wristband in a page of multiple wristbands or with labels or separately, forming the wristband as part of a printer processable business form, and providing the wristband forms either with or without labels in a continuous fan fold or roll format.

Abstract: A printer processible wristband has a cinch slot at one end and an imaging area at another, connected with a strap therebetween. The imaging area is shaped like a shovel and the cinch slot is shaped like a “D” and sized so that the imaging area interference fits through the cinch slot to thereby join the wristband about the wrist. The imaging area may have one of its ends adhered to the strap to clamp it in place and further secure the wristband or it may be left loose to act as a hang tag. Alternate embodiments are disclosed including providing a self adhering label to attach to the imaging area, providing a layer of laminate to laminate the printed information or label, providing a second imaging area along with a second strap, and providing a snap closure to further attach the wristband.

Abstract: A business form including a wristband is provided with a print area forming a badge, the badge having a length less than and a width greater than a width of either of two straps used to attach the wristband to the wrist, the badge thus having a greater print area to improve the readability of the indicia displayed therein. A business form including a wristband has a bulged rectangularly shaped print area to allow information to be printed transversely across the print area to improve readability of the indicia displayed in the print area. Thus, the bulged rectangularly shaped print area can accommodate one or both of bar codes printed thereon in ladder as well as picket fence fashion. A security seal is disclosed which comprises a small, adhesive coated patch of laminate for sealing the joinder of the wristband ends and which has points of weakness such as X's die cut therein so that it separates or destructs upon removal to provide an indication of tampering with the wristband.

Abstract: A business form such as a wristband or label includes an imaging area of face stock overprinted with a fluorescent ink for receiving a printed bar code to enhance the scannability of the bar code. The ink may be applied by overprinting to a thickness of between about 0.2 to about 0.5 mils, and even more preferably to a thickness of about 0.2 mils. The overprint ink is also print receptive allowing a bar code to be printed onto it with no deleterious effects. The imaging area of the wristband form may be overlaminated and the bar code scannability will still be enhanced. An alternative embodiment comprises a face stock manufactured to have a finished surface exhibiting a fluorescent effect similar to that achieved by overprinting through mixing in appropriate components as the face stock is made.

Abstract: A wristband is assembled from a flexible preferably vinyl carrier and a preferably laminated ID label, the carrier having a panel portion and a strap portion with a snap closure located in a toe extension at the end of the carrier adjacent the panel. The strap has a series of holes, one of which is captured within the snap closure to attach the wristband to the wearer's limb. The laminated ID label has a pair of opposing slots, one of which slips over the strap to abut the panel and the other of which is captured by the snap closure to attach the label to the carrier. The panel portion has a relieved edge formed along its opposing sides which increases the comfort of the wristband as it is worn.

Abstract: A business form including a wristband is provided with a print area forming a badge, the badge having a length less than and a width greater than a width of either of two straps used to attach the wristband to the wrist, the badge thus having a greater print area to improve the readability of the indicia displayed therein. A business form including a wristband has a bulged rectangularly shaped print area to allow information to be printed transversely across the print area to improve readability of the indicia displayed in the print area. Thus, the bulged rectangularly shaped print area can accommodate one or both of bar codes printed thereon in ladder as well as picket fence fashion. A security seal is disclosed which comprises a small, adhesive coated patch of laminate for sealing the joinder of the wristband ends and which has points of weakness such as X's die cut therein so that it separates or destructs upon removal to provide an indication of tampering with the wristband.

Abstract: A biological safety system includes a life-support cell, a supply system fluidly connected to the life-support cell, and an exhaust system fluidly connected to the life-support cell. The life-support cell is structured to contain a laboratory animal infected with microorganism of a type that requires bio-safety level 3 (BSL-3) isolation, is transparent to at least one form of radiation to permit observation of the laboratory animal while in use, and the biological safety system contains the microorganism that infect the laboratory animal within the life-support cell while permitting the observations of the laboratory animal from a bio-safety level 2 (BSL-2) environment without the microorganism escaping from the life-support cell.

Abstract: A printer processible wristband has a cinch slot at one end and an imaging area at another, connected with a strap therebetween. The imaging area is shaped like a shovel and the cinch slot is shaped like a “D” and sized so that the imaging area interference fits through the cinch slot to thereby join the wristband about the wrist. The imaging area may have one of its ends adhered to the strap to clamp it in place and further secure the wristband or it may be left loose to act as a hang tag. Alternate embodiments are disclosed including providing a self adhering label to attach to the imaging area, providing a layer of laminate to laminate the printed information or label, providing a second imaging area along with a second strap, and providing a snap closure to further attach the wristband.

Abstract: A wristband is assembled from a flexible preferably vinyl carrier and a preferably laminated ID label, the carrier having a panel portion and a strap portion with a snap closure located in a toe extension at the end of the carrier adjacent the panel. The strap has a series of holes, one of which is captured within the snap closure to attach the wristband to the wearer's limb. The laminated ID label has a pair of opposing slots, one of which slips over the strap to abut the panel and the other of which is captured by the snap closure to attach the label to the carrier. The panel portion has a relieved edge formed along its opposing sides which increases the comfort of the wristband as it is worn.