Abstract: Provided herein are Heterocyclic Compounds of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, compositions comprising an effective amount of a Heterocyclic Compound of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and methods for treating or preventing animal and human filarial worm infections and diseases.

Abstract: Smart wellhead assemblies with sensors for detecting positions of components within the bores of the wellhead assemblies are provided. In some instances, the sensors can be used to detect one or more of landing, locking, or concentricity of hangers, packoffs, or other internal wellhead components within bores. In one example, a method of installing a hanger within a wellhead includes lowering the hanger within the wellhead and using one or more sensors to detect when the hanger is at a target location. The method can also include activating a locking mechanism of the hanger and using the one or more sensors to detect when the locking mechanism has secured the hanger within the wellhead. Additional systems, devices, and methods are also disclosed.

Abstract: Disclosed is an apparatus and method for collecting downhole debris wherein the apparatus comprises a tubular member extending between first and second ends connectable to a production string connectable in fluidic communication with the production string and having an open flow path therethrough between the first and second ends, at least one coiled member extending between first and second ends, said second end being operably connected to the tubular member and a top cap secured to the first end of the coiled member and adapted to sealably close a top end of the coiled member. The method comprises extending the coiled member in response to an upward flow through the tubular member so as to permit upward flow of fluids and solid particles and compressing the coiled member in response to a downward flow so as to permit fluid flow between coils of the coiled member while retaining solid particles thereover.

Abstract: Smart wellhead assemblies with sensors for detecting positions of components within the bores of the wellhead assemblies are provided. In some instances, the sensors can be used to detect one or more of landing, locking, or concentricity of hangers, packoffs, or other internal wellhead components within bores. In one example, a method of installing a hanger within a wellhead includes lowering the hanger within the wellhead and using one or more sensors to detect when the hanger is at a target location. The method can also include activating a locking mechanism of the hanger and using the one or more sensors to detect when the locking mechanism has secured the hanger within the wellhead. Additional systems, devices, and methods are also disclosed.

Abstract: An apparatus and method for assisting transportation of a tool down a wellbore. The apparatus comprises an elongate body having an exterior surface extending between top and bottom ends, a connector at the bottom end operable to be secured above the tool and at least one passage formed into the exterior surface defining a first flow path having an entrance and an exit oriented towards the top end of the elongate body. The method comprises securing the elongate body to a top end of a tool in a wellbore, directing a flow of fluid down the wellbore to a position above the elongate body, separating the flow of the fluid into an inner portion and an outer portion through radially separated paths and redirecting the inner portion to flow upwards into the outer portion of the flow of the fluid.

Abstract: Provided herein are Heterocyclic compounds of formula I: and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R1, R2, and RN are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

Abstract: Provided herein are Heterocyclic compounds of formula I: and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R1, R2, and RN are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

Abstract: Smart wellhead assemblies with sensors for detecting positions of components within the bores of the wellhead assemblies are provided. In some instances, the sensors can be used to detect one or more of landing, locking, or concentricity of hangers, packoffs, or other internal wellhead components within bores. In one example, a method of installing a hanger within a wellhead includes lowering the hanger within the wellhead and using one or more sensors to detect when the hanger is at a target location. The method can also include activating a locking mechanism of the hanger and using the one or more sensors to detect when the locking mechanism has secured the hanger within the wellhead. Additional systems, devices, and methods are also disclosed.

Abstract: An apparatus and method for assisting transportation of a tool down a wellbore. The apparatus comprises an elongate body having an exterior surface extending between top and bottom ends, a connector at the bottom end operable to be secured above the tool and at least one passage formed into the exterior surface defining a first flow path having an entrance and an exit oriented towards the top end of the elongate body. The method comprises securing the elongate body to a top end of a tool in a wellbore, directing a flow of fluid down the wellbore to a position above the elongate body, separating the flow of the fluid into an inner portion and an outer portion through radially separated paths and redirecting the inner portion to flow upwards into the outer portion of the flow of the fluid.

Abstract: Provided herein are Heterocyclic compounds of formula I: and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R1, R2, and RN are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

Abstract: A system includes a running tool having a tool body configured to couple to a hanger assembly, a first sleeve disposed around the tool body and configured to move in an axial direction with respect to the tool body, a torque sleeve disposed around the tool body and configured to move in the axial direction as a result of movement of the first sleeve in the axial direction, where the torque sleeve has a first torque transfer interface configured to interlock with a second torque transfer interface of the hanger assembly to enable torque transfer from the running tool to the hanger assembly, and a second sleeve configured to couple to the first sleeve, where the second sleeve is configured to move to engage a lock member of the hanger assembly and to move the lock member between a locked position and an unlocked position.

Abstract: A system includes a running tool having a tool body configured to couple to a hanger assembly, a first sleeve disposed around the tool body and configured to move in an axial direction with respect to the tool body, a torque sleeve disposed around the tool body and configured to move in the axial direction as a result of movement of the first sleeve in the axial direction, where the torque sleeve has a first torque transfer interface configured to interlock with a second torque transfer interface of the hanger assembly to enable torque transfer from the running tool to the hanger assembly, and a second sleeve configured to couple to the first sleeve, where the second sleeve is configured to move to engage a lock member of the hanger assembly and to move the lock member between a locked position and an unlocked position.

Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (1) stereoisomers thereof, veterinary or pharmaceutical acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables W1, W2, W3, W, X, R1a, R1b, R1c, R2, R3, R4, and n are as described herein.

Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (1) stereoisomers thereof, veterinary or pharmaceutical acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables W1, W2, W3, W, X, R1a, R1b, R1c, R2, R3, R4, and n are as described herein.

Abstract: This invention recites isoxazoline substituted derivatives of Formula (1) stereoisomers thereof, geometric isomers thereof, veterinarily acceptable salts 5 thereof, compositions thereof, and their use as a parasiticide in animals. The variables A, W, R 1a, R 1b, R 1c, R 2, R 3, R 5, and n are as described herein.

Abstract: This invention recites isoxazoline substituted derivatives of Formula (1) stereoisomers thereof, geometric isomers thereof, veterinarily acceptable salts 5 thereof, compositions thereof, and their use as a parasiticide in animals. The variables A, W, R 1a, R 1b, R 1c, R 2, R 3, R 5, and n are as described herein.

Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W1, W2, W3, W, Y, X, R1a, R1b, R1c, R2, R3, R4, n, and “” are as described herein.

Abstract: By using a unified generic resource provisioning system, all of an organization's resources may be provisioned through a single user interface system, a single cohesive data model, and a single consistent model of access. The system described herein provisions an organization's resources to both new and existing employees in response to different employee events. For example, in response to a single event that indicates that an employee has been hired by the company, he is automatically given access to a phone, a badge, a virtual machine, and SSL certificates that he can use during his employment with the company. Much later, when the same employee terminates his employment with the company, that employee's access to all of these resources is revoked in response to another single event, such as an event originating from a human resources department, indicating that employee's last date of hire with the company.

Abstract: A centralized notification engine, which serves notifications from multiple applications, receives a request to register a notification from a particular application. Responsive to the request, the notification engine stores information that indicates a context of the notification. The notification engine determines whether the notification satisfies metadata-specified constraints. Responsive to determining that the notification satisfies the constraints, the notification engine selects, from a set of templates, a template that is associated with the notification's context. The notification engine applies the template to information specified by the notification. As a result, a populated template is produced.

Abstract: This invention recites isoxazoline substituted azetidine derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in mammals and birds. R1a, R1b, R1c, R2, R3, R4, R6, and n are as described herein.