Patents by Inventor Sanjay Ram

Sanjay Ram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-antigenic peptide mimics of gonococcal lipo-oligosaccharide (LOS) epitopes
    Patent number: 12629410
    Abstract: In some aspects, the disclosure relates to compositions of peptide mimics useful in the treatment of Neisseria gonorrhoeae (N. gonorrhoeae). In some embodiments, the peptide mimics are multi-antigenic molecules of a conserved gonococcal lipo-oligosaccharaide (LOS) epitope. In some aspects, the disclosure relates to methods of making peptide mimics for the treatment of N. gonorrhoeae. In some aspects, the disclosure relates to methods of using peptide mimics for the treatment of N. gonorrhoeae.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: May 19, 2026
    Assignee: University of Massachusetts
    Inventors: Peter A. Rice, Michael W. Pennington, Sunita Gulati, Jutamas Shaughnessy, Sanjay Ram
  • HUMANIZED ANTIBODIES AGAINST NEISSERIA GONORRHOEAE AND METHODS OF USE THEREOF
    Publication number: 20240294615
    Abstract: Provided are humanized antibodies that bind to the 2C7 epitope of Neisseria gonorrhoeae. Also provided are compositions and methods for treating Neisseria gonorrhoeae infection in a subject in need thereof.
    Type: Application
    Filed: January 10, 2024
    Publication date: September 5, 2024
    Inventors: Jutamas SHAUGHNESSY, Peter A. RICE, Sunita GULATI, Sanjay RAM, Celia SCHIFFER
  • HUMANIZED 2C7 MONOCLONAL ANTIBODY DIRECTED AGAINST A NEISSERIA GONORRHOEAE LIPOOLIGOSACCHARIDE (LOS) EPITOPE, FOR HUMAN USE
    Publication number: 20210188952
    Abstract: Provided are humanized antibodies that bind to the 2C7 epitope of Neisseria gonorrhoeae. Also provided are compositions and methods for treating Neisseria gonorrhoeae infection in a subject in need thereof.
    Type: Application
    Filed: November 16, 2018
    Publication date: June 24, 2021
    Inventors: Peter A. RICE, Sunita GULATI, Sanjay RAM
  • Factor H-Fc immunotheraphy
    Patent number: 10975131
    Abstract: Fusion proteins comprising human FH domains 18-20 (FH18-20) linked via an optional linker to IgG Fc, wherein the FH has mutation of D to G at position 1119 in domain 19; FHD1119G/Fc), and methods of use thereof, e.g., to treat pathogen infections.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: April 13, 2021
    Assignee: University of Massachusetts
    Inventors: Sanjay Ram, Douglas T. Golenbock, Alberto Visintin, Jutamas Shaughnessy
  • therapeutic based on CMP-nonulosonate sugars
    Patent number: 10865222
    Abstract: N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant gonorrhea.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: December 15, 2020
    Assignees: National Research Council of Canada, University of Massachusetts Medical School
    Inventors: Ian Schoenhofen, Dennis M. Whitfield, Sanjay Ram
  • Factor H-Fc Immunotheraphy
    Publication number: 20180305425
    Abstract: Fusion proteins comprising human FH domains 18-20 (FH18-20) linked via an optional linker to IgG Fc, wherein the FH has mutation of D to G at position 1119 in domain 19; FHD1119G/Fc), and methods of use thereof, e.g., to treat pathogen infections.
    Type: Application
    Filed: October 27, 2016
    Publication date: October 25, 2018
    Inventors: Sanjay Ram, Douglas T. Golenbock, Alberto Visintin, Jutamas Shaughnessy
  • Novel Neisseria Gonorrhoeae Therapeutic Based on CMP-Nonulosonate Sugars
    Publication number: 20170362269
    Abstract: N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant gonorrhea.
    Type: Application
    Filed: September 1, 2017
    Publication date: December 21, 2017
    Applicants: National Research Council of Canada, University of Massachusetts Medical School
    Inventors: Ian SCHOENHOFEN, Dennis M. WHITFIELD, Sanjay RAM
  • therapeutic based on CMP-nonulosonate sugars
    Patent number: 9765106
    Abstract: N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogs to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant gonorrhea.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: September 19, 2017
    Assignee: National Research Council of Canada
    Inventors: Ian Schoenhofen, Dennis M. Whitfield, Sanjay Ram
  • Methods, compositions and vaccines relating to antibodies
    Patent number: 9475864
    Abstract: The invention provides compositions and methods for screening subjects at risk for contracting meningococcal disease and/or at risk for failing to elicit an immunogenic response to a vaccine against Neisseria meningitidis. The invention also provides kits for carrying out these screens, and improved vaccines against Neisseria meningitidis.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: October 25, 2016
    Assignee: University of Massachusetts
    Inventors: Sanjay Ram, Tathagat Duttaray, Peter A. Rice, Lisa A. Lewis, Sunita Gulati
  • Novel Neisseria gonorrhoeae therapeutic based on CMP-nonulosonate sugars
    Publication number: 20150232502
    Abstract: N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant gonorrhea.
    Type: Application
    Filed: February 20, 2015
    Publication date: August 20, 2015
    Applicants: UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Ian Schoenhofen, Dennis M. Whitfield, Sanjay RAM
  • Complement factor H-based assays for serum bactericidal activity against
    Patent number: 8476032
    Abstract: Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: July 2, 2013
    Assignees: Children's Hospital & Research Center Oakland, Novartis Vaccines and Diagnostics, SRL, The University of Massachusetts
    Inventors: Dan M. Granoff, JoAnne Welsch, Sanjay Ram
  • METHODS, COMPOSITIONS AND VACCINES RELATING TO NEISSERIA MENINGITIDIS ANTIBODIES
    Publication number: 20110229522
    Abstract: The invention provides compositions and methods for screening subjects at risk for contracting meningococcal disease and/or at risk for failing to elicit an immunogenic response to a vaccine against Neisseria meningitidis. The invention also provides kits for carrying out these screens, and improved vaccines against Neisseria meningitidis.
    Type: Application
    Filed: September 4, 2009
    Publication date: September 22, 2011
    Applicant: University of Massachusetts
    Inventors: Sanjay Ram, Tathagat Duttaray, Peter A. Rice, Lisa A. Lewis, Sunita Gulati
  • COMPLEMENT FACTOR H-BASED ASSAYS FOR SERUM BACTERICIDAL ACTIVITY AGAINST NEISSERIA MENINGITIDIS
    Publication number: 20100240075
    Abstract: Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.
    Type: Application
    Filed: August 26, 2009
    Publication date: September 23, 2010
    Inventors: Dan M. Granoff, JoAnne Welsch, Sanjay Ram