Abstract: The present invention is directed to a system for mediating an electronic communication between a forum and a non-member of the forum. The system includes a server having programmatic instructions where execution of the programmatic instructions by a processor a) generates data representative of a GUI, where the GUI prompts a user to input a query, b) receives data representative of the query, c) parses data representative of the query and uses the parsed data to create a forum interface call, d) transmits the forum interface call to remotely located servers, where at least some of the servers hosts at least one forum, e) in response to the transmission of forum interface calls, receives responses responsive to the query, and f) generates data representative of another GUI, which provides a user electronic access to the responses.

Abstract: The present invention provides a system that allows users to directly participate in advertising resource allocation decisions for advertisers and to actively cause navigation swarms to specific websites. Swarms of users can be enabled by playing a form of hide and seek, where users (hiders) actively hide at a specific network location (the place where a swarm is desired) and other users (seekers) then actively search for the hiding users, thereby creating a swarm effect toward a particular site or set of sites.

Abstract: The present invention relates to methods of and compositions for treating and relieving symptoms and disease associated with indications caused by a physiological drive to alleviate a sensation of anxiety. In one treatment method, methods of, and compositions for, modulating the expression of certain GABAA receptor subunits are used to treat anxiety-related disorders and depressive disorders associated with physiological tolerance to endogenous neurosteroids.

Abstract: The present invention is directed to a system for mediating an electronic communication between a forum and a non-member of the forum. The system includes a server having programmatic instructions where execution of the programmatic instructions by a processor a) generates data representative of a GUI, where the GUI prompts a user to input a query, b) receives data representative of the query, c) parses data representative of the query and uses the parsed data to create a forum interface call, d) transmits the forum interface call to remotely located servers, where at least some of the servers hosts at least one forum, e) in response to the transmission of forum interface calls, receives responses responsive to the query, and f) generates data representative of another GUI, which provides a user electronic access to the responses.

Abstract: The present invention relates to methods of and compositions for treating and relieving symptoms and disease associated with indications caused by a physiological drive to alleviate a sensation of anxiety. In one treatment method, methods of, and compositions for, modulating the expression of certain GABAA receptor subunits are used to treat anxiety-related disorders and depressive disorders associated with physiological tolerance to endogenous neurosteroids.

Abstract: The present invention relates to methods of and compositions for treating and relieving symptoms and disease associated with indications caused by a physiological drive to alleviate a sensation of anxiety. More specifically, the present invention relates to methods of and compositions for treating and relieving symptoms associated with substance abuse and withdrawal. The present invention relates to methods of and compositions for treating and relieving symptoms associated with addiction to antidepressants, opiates, nicotine or marijuana. In one method, a patient is treated with a composition that directly or indirectly modulates GABAA by modulating the expression of the GABAA receptor a4 subunit.

Abstract: Compositions for reducing dependency and addiction to substances of abuse are provided. Chloride channels such as the GABAA receptors are altered under conditions of dependency and withdrawal such that the electrophysiological properties of the GABAA receptor containing neurons are altered thereby providing a pathophysiological condition resulting in symptoms of dependency and withdrawal such as anxiety. Specifically, under conditions of withdrawal the relative ratio of the a1 receptor subunit decreases relative to the a4 receptor subunit. Endogenous neurosteroid production is also associated with the molecular changes underlying the alterations of GABA-gated chloride channels. Compositions of at least two compounds including at least one inhibitor of neurosteroid production are useful for treating the pathophysiology of addiction, dependency and substance abuse withdrawal.