Abstract: A system and a method for performing a cost-utility analysis of pharmaceutical interventions where each pharmaceutical intervention is associated with several potential health states. The system includes a processor and a database. The database contains for each pharmaceutical intervention several utility values associated with each health state and a probability for each potential health state associated with each pharmaceutical intervention. The processor is in communication with the database and determines a mean utility value for each pharmaceutical intervention by correlating each probability associated with each pharmaceutical intervention with the utility value associated with the respective health state. The processor also compares the pharmaceutical interventions the mean utility values of the pharmaceutical interventions by decision analysis.

Abstract: The present invention relates to new rapamycin derivatives for the inhibition of cell proliferation. The compounds can advantageously target two proteins in dividing cells and interfere with cell cycle. There is thus provided derivatives of rapamycin in which the 42 position of rapamycin is linked to an amino acid or a peptide through a carbamate ester linkage. These rapamycin derivatives can be synthesized by reacting 42-O-(4-Nitrophenoxycarbonyl) rapamycin and an amino acid or a free amino peptide under basic conditions. These rapamycin derivatives can be used to inhibit the cell cycle and are therefore useful for treating cell proliferation disorders.

Abstract: The capability to handle the 100 ?s RPR interrupt and similar interrupts is provided by servicing selected interrupts outside of the operating system. This drastically reduces the latency and overhead associated with servicing the interrupt. A method of handling an interrupt in a computer system comprises receiving the interrupt at the computer system, determining whether the interrupt is a selected interrupt, and performing interrupt processing not involving an operating system of the computer system, if the interrupt is a selected interrupt.

Abstract: RPR traffic management concepts are extended to individual client flows while adhering to the station level traffic management functions by using a two tiered shaper approach. The first tier manages the client level SLAs and feeds the second tier which provides the aggregate station level traffic management functions. This approach allows sharing of a single RPR station without the compromises and side affects associated with the other techniques. Apparatus for Resilient Packet Ring traffic management comprises a stage queue selection block operable to hold client and control traffic for transmission, a queue level traffic shaper operable to control an add rate of client data add traffic and to provide queue specific send indications to the stage queue selection block, and a ringlet level traffic shaper operable to control traffic flow for a Resilient Packet Ring ringlet and to provide aggregate send indications to the stage queue selection block.

Abstract: A distributed memory switch system for transmitting packets from source ports to destination ports, comprising: a plurality of ports including a source port and a destination port wherein a packet is transmitted from the source port to the destination port; a memory pool; and an interconnection stage coupled between the plurality of ports and the memory pool such that the interconnection stage permits a packet to be transmitted from the source port to the destination port via the memory pool.

Abstract: A distributed memory switch system for transmitting packets from source ports to destination ports, comprising: a plurality of ports including a source port and a destination port wherein a packet is transmitted from the source port to the destination port; a memory pool; and an interconnection stage coupled between the plurality of ports and the memory pool such that the interconnection stage permits a packet to be transmitted from the source port to the destination port via the memory pool.

Abstract: Transdermal systems for providing sustained delivery of a drug over a lengthy duration are disclosed and described. In certain aspects, such systems may take the form of a transdermal patch that includes, in addition to traditional components such as a backing member and a peelable release liner, a polymeric storage layer, a polymeric delivery layer, and a rate controlling member disposed therebetween.

Abstract: A method and system which numerically quantifies a person's loss of quality of life (QOL), i.e., the value of remaining life, due to the occurrence of an injury. The system includes a processor in communication with a health-related QOL measures (e.g., health state utility value) database. Raw data are inputted into the processor. The raw data provide information regarding the person's life expectancy and health state before and after the occurrence of the injury. The processor calculates a reference value of the person's QOL as if the injury did not occur. The processor then calculates the person's actual loss of value of QOL due to the occurrence of the injury. Finally, the processor calculates a QOL disability index by dividing the person's actual loss of value of QOL by the reference value. The QOL disability index is used to determine an amount of monetary damages to be awarded in a tort case.

Abstract: A distributed memory switch system for transmitting packets from source ports to destination ports, comprising: a plurality of ports including a source port and a destination port wherein a packet is transmitted from the source port to the destination port; a memory pool; and an interconnection stage coupled between the plurality of ports and the memory pool such that the interconnection stage permits a packet to be transmitted from the source port to the destination port via the memory pool.

Abstract: The present invention relates to a method of deposition of an absorbing material upon a plastic/glass substrate by vacuum coating at an angle of inclination between 5° to 30° and using a mask on the evaporation source to produce a graded film material and a method for the preparation of graded density absorbing film useful as an antiglare optical device for protecting the eyes by reducing the glare by absorbing the light intensity falling upon it in a non-uniform fashion.

Abstract: The present invention relates to a method of deposition of an absorbing material upon a plastic/glass substrate by vacuum coating at an angle of inclination between 5° to 30° and using a mask on the evaporation source to produce a graded film material and a method for the preparation of graded density absorbing film useful as an antiglare optical device for protecting the eyes by reducing the glare by absorbing the light intensity falling upon it in a non-uniform fashion.

Abstract: A method for analysis of environmental load burdens and associated costs for products, processes and services, which takes into account both life cycle assessment and activity based costing. The steps entailed in the method include representing the at least one product, process or service as a process hierarchy having at least one elemental component having at least one baseline process associated therewith; associating at least one driver corresponding to the at least one elemental component, with at least one environmental load/substance category; calculating a first metric reflective of an environmental load of providing the at least one product, process or service; and calculating a second metric reflective of a cost of providing the at least one product, processor service.

Abstract: An open high-speed local system bus for a microcomputer system which is decoupled from I/O and provides a consistent interface to the CPU subsystem, memory subsystem, graphics subsystem and peripheral subsystem. The local system bus supports discrete and burst transactions, pipelining in both the transactions, multiple microprocessor and distributed interrupts.