Abstract: A method for data sharing between cloud deployments is disclosed. A provider in a virtual private cloud (VPC) deployment generates a listing of data for sharing with a consumer in a public multi-tenant deployment. After creating a public account and transmitting a link associated with the listing to the consumer, the method responds to the consumer's selection of the link by automatically creating a secure shared area in the VPC deployment. The method includes replicating both a database and share object associated with the listing into the secure shared area as respective replicas. The replicated objects are then shared with the consumer account as data share objects, enabling the consumer to launch them in a consumer mounted database. The method concludes by enabling the consumer to perform database operations on the provider's data within the VPC deployment, ensuring secure and efficient data sharing between the cloud environments.

Abstract: A method for secure data synchronization and sharing between distinct cloud environments is disclosed. The method involves establishing a trust relationship between a data provider's private cloud deployment and a data consumer's public cloud deployment. Utilizing hardware processors, a cross-region group sharing token is generated and validated to facilitate secure communication and data traffic between the two cloud deployments. Upon validation, a firewall policy that previously restricted data exchange is disabled, allowing for the replication of a target database from the private cloud to a secure share area accessible by the public cloud deployment. The data consumer is then enabled to access and utilize the replicated database within this secure area. The method ensures consistent data management across both deployments by managing the synchronization of the replicated database with the data provider's original database, thereby maintaining data consistency and integrity.

Abstract: Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “a”, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

Abstract: A method for secure data synchronization and sharing between distinct cloud environments is disclosed. The method involves establishing a trust relationship between a data provider's private cloud deployment and a data consumer's public cloud deployment. Utilizing hardware processors, a cross-region group sharing token is generated and validated to facilitate secure communication and data traffic between the two cloud deployments. Upon validation, a firewall policy that previously restricted data exchange is disabled, allowing for the replication of a target database from the private cloud to a secure share area accessible by the public cloud deployment. The data consumer is then enabled to access and utilize the replicated database within this secure area. The method ensures consistent data management across both deployments by managing the synchronization of the replicated database with the data provider's original database, thereby maintaining data consistency and integrity.

Abstract: Methods, systems, and computer programs are presented for enabling automated secure data sharing from a private cloud region to a public cloud region and vice versa. A cloud data platform confirms a relationship establishment procedure between a provider and a consumer is recorded with a cloud data platform, the provider being associated with a private cloud deployment and the consumer being associated with a public cloud deployment in a public region. The cloud data platform enables disabling of a firewall policy that is preventing data traffic between the private cloud deployment and the public cloud deployment and enables data sharing between the private cloud deployment and the public cloud deployment. The cloud data platform enables data sharing in a database of the cloud data platform.

Abstract: Example notification management systems and methods are described. In one implementation, techniques identify multiple devices communicating using a carrier and identify a trigger associated with at least one of the multiple devices. Based on identifying the trigger, the techniques may apply at least one business rule associated with at least one of the multiple devices. The techniques may further generate at least one notification in response to applying the business rule.

Abstract: Example device management systems and methods are described. In one implementation, techniques identify a first plurality of devices communicating using a first rate plan associated with a carrier. The techniques further identify a second plurality of devices communicating using a second rate plan associated with the carrier. The techniques analyze the first rate plan and the second rate plan based on data usage. The techniques then identify at least one recommended rate plan change for at least one of the first plurality of devices or the second plurality of devices based on the analysis.

Abstract: Example bulk device processing systems and methods are described. In one implementation, techniques receive a plurality of application programming interface (API) requests, where each of the plurality of API requests is associated with a particular device. The techniques further sort the plurality of API requests based on an associated carrier. The techniques also create a first batch of API calls associated with devices using a first carrier and create a second batch of API calls associated with devices using a second carrier. The techniques then create multiple threads for parallel execution of the first batch of API calls and the second batch of API calls, and automatically execute the API calls associated with the plurality of threads.

Abstract: A method includes detecting, by a computing device, a plurality of transactions on one or more data storage system. The method further includes sequentially recording, by the computing device, the plurality of transactions occurring on the one or more data storage system in sequentially linked and immutable blocks.

Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts and N-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by “a”, R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the eIF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.

Abstract: Example notification management systems and methods are described. In one implementation, techniques identify multiple devices communicating using a carrier and identify a trigger associated with at least one of the multiple devices. Based on identifying the trigger, the techniques may apply at least one business rule associated with at least one of the multiple devices. The techniques may further generate at least one notification in response to applying the business rule.

Abstract: Example device management systems and methods are described. In one implementation, techniques identify a first plurality of devices communicating using a first rate plan associated with a carrier. The techniques further identify a second plurality of devices communicating using a second rate plan associated with the carrier. The techniques analyze the first rate plan and the second rate plan based on data usage. The techniques then identify at least one recommended rate plan change for at least one of the first plurality of devices or the second plurality of devices based on the analysis.

Abstract: Example bulk device processing systems and methods are described. In one implementation, techniques receive a plurality of application programming interface (API) requests, where each of the plurality of API requests is associated with a particular device. The techniques further sort the plurality of API requests based on an associated carrier. The techniques also create a first batch of API calls associated with devices using a first carrier and create a second batch of API calls associated with devices using a second carrier. The techniques then create multiple threads for parallel execution of the first batch of API calls and the second batch of API calls, and automatically execute the API calls associated with the plurality of threads.

Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts and N-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by “a”, R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the eIF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.

Abstract: Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “a”, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure (I) and pharmaceutically acceptable salts and/V-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by “a”, R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the eIF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.

Abstract: Present invention relates to a low dose pharmaceutical composition, preferably oral composition comprising therapeutically effective amount of [(2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diaza-benzo[a]azulene-3-carbonyl)-amino]-acetic acid (compound A) in the range of 2.5 mg to 60 mg. Present invention also relates to a method of treating inflammatory bowel disease in a mammal by administrating said low dose pharmaceutical composition. Further, present invention relates to a use of the compound A for the preparation of low dose pharmaceutical composition for the treatment of inflammatory bowel disease in a mammal.

Abstract: Provided herein are novel fused pyrimidinone derivatives of Formula I and synthetic intermediates that are useful in preparing the compounds of formula (I). Further provided herein is a method for preparation of a compound of formula (I) or intermediates, a pharmaceutical composition comprising a compound of formula (I), and use of a compound of formula (I).

Abstract: The present invention relates to novel fused Imidazobenzothiazole derivatives, their pharmaceutically acceptable salts, and their isomers, stereoisomers, atropisomers, conformers, tautomers, polymorphs, hydrates, solvates and N-oxide. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

Abstract: Disclosed are pyrazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure (I) and pharmaceutically acceptable salts and/V-oxides thereof, wherein X1, X2, Z1, Z2, the ring system denoted by “a”, R1, A1A, L1B, A1B, L1A, L2, Q, L3, R3, A4A, L4B, A4B, L4A, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein disrupt the elF4E/eiF4G interaction, and can be used to treat hyperproliferative disorder, a neurological disease or disorder, or autism.