Patents by Inventor Sanjaya Singh

Sanjaya Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MATERIALS AND METHODS FOR IN VIVO BIOLOGICAL TARGETING
    Publication number: 20210214440
    Abstract: An isolated molecule, comprising: a first antigen binding domain and a second antigen binding domain, wherein the first antigen binding domain specifically binds CD8 and the second antigen binding domain specifically binds a T cell receptor (TCR) complex.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 15, 2021
    Applicant: Janssen Biotech, Inc.
    Inventors: Rajkumar Ganesan, Sanjaya Singh, Iqbal S. Grewal, Michael Riis Hansen
  • ANTI-IL-23 ANTIBODIES
    Publication number: 20210198355
    Abstract: The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.
    Type: Application
    Filed: October 9, 2020
    Publication date: July 1, 2021
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Rachel Rebecca Barrett, Keith A. Canada, Katrina Mary Catron, Robert Copenhaver, Lee Edward Frego, Ernest Lee Raymond, Sanjaya Singh, Xiangyang Zhu
  • METHODS FOR PRODUCING BIOTHERAPEUTICS WITH INCREASED STABILITY BY SEQUENCE OPTIMIZATION
    Publication number: 20210130440
    Abstract: The invention relates to methods of optimizing an antibody with enhanced stability, the method comprising mutating somatic hypermutation with germline amino acid residues and therefore providing enhanced thermal stability, improved biophysical properties and shelf-life while preserving the affinity for the antigen.
    Type: Application
    Filed: October 2, 2020
    Publication date: May 6, 2021
    Inventors: Sathyadevi Venkataramani, Rajkumar Ganesan, Sanjaya Singh
  • COMPOUND TARGETING IL-23A AND B-CELL ACTIVATING FACTOR (BAFF) AND USES THEREOF
    Publication number: 20210107998
    Abstract: The disclosure relates to compounds specific for IL23A and BAFF, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells, and methods of production related to the compounds and compositions are also disclosed.
    Type: Application
    Filed: October 22, 2020
    Publication date: April 15, 2021
    Inventors: Sanjaya SINGH, Qi PAN, Rachel Rebecca BARRETT, Leslie S. JOHNSON, Pankaj GUPTA, Sarah LOW, Haixia WU
  • COMPOUND TARGETING IL-23A AND TNF-ALPHA AND USES THEREOF
    Publication number: 20210054065
    Abstract: The disclosure relates to compounds specific for IL23A and TNF-alpha, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells, and methods of production related to the compounds and compositions are also disclosed.
    Type: Application
    Filed: August 26, 2020
    Publication date: February 25, 2021
    Inventors: Rachel Rebecca Barrett, Leslie S. Johnson, Sanjaya Singh, Kathleen Last-Barney, Daw-Tsun Shih, Patricia Giblin, Scott Brodeur, Nelamangala Nagaraja
  • Proteins Comprising Kallikrein Related Peptidase 2 Antigen Binding Domains And Their Uses
    Publication number: 20210040210
    Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.
    Type: Application
    Filed: July 23, 2020
    Publication date: February 11, 2021
    Inventors: Rajkumar Ganesan, John Lee, Jinquan Luo, Theresa McDevitt, Fei Shen, Degang Song, Raymond Brittingham, Sathyadevi Venkataramani, Sanjaya Singh, Yonghong Zhao, Fang Yi, Sherry Lynn La Porte
  • MATERIALS AND METHODS FOR MODULATING T CELL MEDIATED IMMUNITY
    Publication number: 20210032338
    Abstract: Anti-TRGV9 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases, such as cancer.
    Type: Application
    Filed: May 7, 2020
    Publication date: February 4, 2021
    Inventors: Rajkumar Ganesan, Iqbal S. Grewal, Sanjaya Singh
  • ANTI-TRKB ANTIBODIES
    Publication number: 20200399378
    Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.
    Type: Application
    Filed: August 26, 2020
    Publication date: December 24, 2020
    Inventors: Rolf HERRMANN, Remko Alexander BAKKER, Sebastian BANDHOLTZ, Peter Michael BENZ, Michael DZIEGELEWSKI, Lore Katharina FLORIN, Cynthia Hess KENNY, Sarah Kathleen LOW, Holger ROSENBROCK, Sanjaya SINGH, Heiko Friedrich STAHL, Sathyadevi VENKATARAMANI, Vladimir H. VOYNOV, Haiguang XIAO
  • ANTI-SEMA3A ANTIBODIES AND THEIR USES FOR TREATING EYE OR OCULAR DISEASES
    Publication number: 20200385446
    Abstract: The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.
    Type: Application
    Filed: May 8, 2020
    Publication date: December 10, 2020
    Inventors: Leo THOMAS, Rachel Rebecca BARRETT, Kristin Laura BOVAT, Rajkumar GANESAN, Priyanka GUPTA, Fei HAN, Dongmei LIU, Juergen PRESTLE, Sanjaya SINGH, Sathyadevi VENKATARAMANI, Helen HAIXIA WU, Nina ZIPPEL
  • Compound targeting IL-23A and B-cell activating factor (BAFF) and uses thereof
    Patent number: 10844138
    Abstract: The disclosure relates to compounds specific for IL23A and BAFF, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells, and methods of production related to the compounds and compositions are also disclosed.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: November 24, 2020
    Assignees: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, MACROGENICS, INC.
    Inventors: Sanjaya Singh, Qi Pan, Rachel Rebecca Barrett, Leslie S. Johnson, Pankaj Gupta, Sarah Low, Haixia Wu
  • Anti-TrkB antibodies
    Patent number: 10793634
    Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: October 6, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rolf Herrmann, Remko Alexander Bakker, Sebastian Bandholtz, Peter Michael Benz, Michael Dziegelewski, Lore Florin, Cynthia Hess Kenny, Sarah Low, Holger Rosenbrock, Sanjaya Singh, Heiko Friedrich Stahl, Sathyadevi Venkataramani, Vladimir Voynov, Haiguang Xiao
  • Compound targeting IL-23A and TNF-alpha and uses thereof
    Patent number: 10793629
    Abstract: The disclosure relates to compounds specific for IL23A and TNF-alpha, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells, and methods of production related to the compounds and compositions are also disclosed.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: October 6, 2020
    Assignees: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, MACROGENICS, INC.
    Inventors: Rachel Rebecca Barrett, Leslie S. Johnson, Sanjaya Singh, Kathleen Last-Barney, Daw-Tsun Shih, Patricia Giblin, Scott Brodeur, Nelamangala Nagaraja
  • Antibodies to Pyroglutamate Amyloid-B and Uses Thereof
    Publication number: 20200308261
    Abstract: The invention provides antibodies or antigen binding fragments thereof that bind to 3pE A? and methods of making and using the antibodies or antigen binding fragments thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other ?-amyloid-related diseases.
    Type: Application
    Filed: March 25, 2020
    Publication date: October 1, 2020
    Inventors: Bianca Van Broeck, Marc Mercken, Wilson Edwards, Sanjaya Singh, Jinquan Luo, Sherry La Porte, Rajkumar Ganesan, Chichi Huang
  • Novel Anti-IL13 Antibodies and Uses Thereof
    Publication number: 20200291106
    Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
    Type: Application
    Filed: November 13, 2019
    Publication date: September 17, 2020
    Applicant: Genentech, Inc.
    Inventors: Sek Chung FUNG, Matthew MOYLE, Mason LU, Changning YAN, Sanjaya SINGH, Dan HUANG
  • GAMMA DELTA T CELLS AND USES THEREOF
    Publication number: 20200268797
    Abstract: Provided are methods of expanding and isolating ?? T cells from human peripheral blood mononuclear cells (PBMCs). Also provided are isolated ?? T cells, CAR-?? T cells, and methods of using the same.
    Type: Application
    Filed: November 22, 2019
    Publication date: August 27, 2020
    Inventors: Rajkumar GANESAN, Iqbal S. GREWAL, Sanjaya SINGH
  • GPRC5D CHIMERIC ANTIGEN RECEPTORS AND CELLS EXPRESSING THE SAME
    Publication number: 20200231686
    Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for the treatment of cancer.
    Type: Application
    Filed: January 15, 2020
    Publication date: July 23, 2020
    Inventors: Ricardo Attar, Rajkumar Ganesan, Francois Gaudet, Bradley J. Heidrich, Carmen Baca Jones, John Lee, Yingzhe Li, Sanjaya Singh, Sathya Venkataramani
  • MONOSPECIFIC AND MULTISPECIFC ANTI-TMEFF2 ANTIBODIES AND THEIR USES
    Publication number: 20190359711
    Abstract: The disclosure provided herein relates to monospecific and multispecific anti-TMEFF2 antibodies, and methods of producing and using the described antibodies.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 28, 2019
    Applicant: Janssen Biotech, Inc.
    Inventors: Philip Cooper, Robin Ernst, Rajkumar Ganesan, Colleen Kane, Michael Russell, Sanjaya Singh, Sathyadevi Venkataramani, Sheng-Jiun Wu
  • CX3CR1-BINDING POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS
    Publication number: 20190322753
    Abstract: The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 24, 2019
    Inventors: Sanjaya Singh, Alisa K. Waterman, Erik Depla, Toon Laeremans, Diane Van Hoorick, Cedric Jozef Néotère Ververken
  • NOVEL ANTI-BAFF ANTIBODIES
    Publication number: 20190309034
    Abstract: The present invention relates to anti-BAFF antibody molecules, including novel humanized anti-BAFF antibodies, therapeutic and diagnostic methods and compositions for using the same.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 10, 2019
    Inventors: Scott Ronald BRODEUR, Keith A. CANADA, Michael DZIEGELEWSKI, Philip Nicholas GORMAN, Pankaj GUPTA, Ashraf KHALIL, John J. MIGLIETTA, Amy Marie NICOLETTI, Qi PAN, David PRESKY, Sanjaya SINGH, Tao WU, Haiguang XIAO
  • CX3CR1-binding polypeptides comprising immunoglobulin single variable domains
    Patent number: 10385134
    Abstract: The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: August 20, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Sanjaya Singh, Alisa K. Waterman, Erik Depla, Toon Laeremans, Diane Van Hoorick, Cedric Jozef Néotère Ververken