Abstract: Antibodies and antigen binding regions that bind delta-like protein 3 (DLL3) are described. Multispecific antigen-binding constructs, such as bispecific antibodies, containing the antigen-binding regions that bind to DLL3 are also described. The application also describes methods of treatment or detection using the anti-DLL3 antibodies, antigen-binding fragments or multispecific antigen-binding constructs thereof, and related molecules, compositions and methods.

Abstract: Systems and methods for thermal curing of water soluble polymers for silicon dominant anodes to improve the mechanical properties of the anode and electrochemical performance of a battery are provided.

Abstract: Systems and/or methods of the present disclosure enable ledger interoperability using a controller to perform an operation between a first user and a second user on separate entity-specific distributed ledgers, where the separate entity-specific distributed ledgers are both operatively linked to a membered common distributed ledger. The controller burns a first quantity of first entity-specific tokens from the first entity-specific distributed ledger and mints a second quantity of the common tokens on the membered common distributed ledger, where the first quantity of first entity-specific tokens and the second quantity of the common tokens represent an equivalency. The controller moves the second quantity of common tokens from a first encrypted storage to a second encrypted storage of the membered common distributed ledger, burns the second quantity of the common tokens and mints a third quantity of the second entity-specific tokens on the second entity-specific distributed ledger to complete the operation.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed to generate and manage a firewall policy. An example includes interface circuitry, machine readable instructions, and programmable circuitry to at least one of instantiate or execute the machine readable instructions to determine whether an operation is allowed to pass between a first component on a system-on-chip (SoC) and a second component on the SoC, detect an interconnect between the first component on the SoC and the second component on the SoC, cause the interconnect to filter the operation based on the determination of whether the operation is allowed to pass between the first component and the second component, and transmit a request to filter the operation based on the determination of whether the operation is allowed to pass between the first component and the second component.

Abstract: The disclosure provided herein relates to monospecific and multispecific anti-TMEFF2 antibodies, and methods of producing and using the described antibodies.

Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: Described herein are peptides of formula (I) and pharmaceutical compositions and kits comprising the peptides. The use of the peptides in methods of treating or preventing diseases that are associated with modulation of Amyloid-beta protein-degrading proteases, such as neprilysin and angiotensin-converting enzyme 2, are also described.

Abstract: Apparatus and associated methods relate to configuring secure access to a patient's stored health record data, in response to receiving the patient's consent to a health record data access request, and providing the secure access to a specific user at a location and time related to the request. The access request may be received from a provider. The provider may be a doctor. Secure access by a specific user to a discrete health record data field may be configured, granted, or revoked based on patient consent status, permitting the patient selective control over access to their personal health record data. Access encryption parameters distinct from the storage encryption parameters securing the stored health record may be configured to permit specific user access to a specific data field. The access encryption parameters may be revoked by the patient withdrawing consent, permitting the patient to assert ownership control of their health records.

Abstract: An object of the present disclosure is to provide a flight management apparatus capable of improving the safety of flying objects. In one example, a flight management apparatus (10) of the present disclosure includes a determination unit (12) configured to determine whether a specific space cell in a space is already reserved based on a reservation state about the specific space cell, when the flight management apparatus receives a request for permission to move to the specific space cell from a flying object; and a permission unit (13) configured to permit the movement to the specific space cell of the flying object when the determination unit determines the specific space cell is not reserved, and not to permit the movement to the specific space cell of the flying object when the determination unit determines the specific space cell is already reserved.

Abstract: A controller, method, and computer-readable medium for uninterrupted transmission processing and continuous net transmission among a plurality of clients of the distributed ledger, including receiving instructions to perform transmissions, each transmission having parameters for transfer of a first quantity of first entity-specific tokens corresponding to a first entity to a second quantity of second entity-specific tokens corresponding to a second entity that is a client of the distributed ledger network, writing one or more transmissions in the plurality of transmissions to one or more new blocks on a transmission blockchain of the distributed ledger network, each new block storing at least one transmission in the one or more transmissions, and initiating a net transmission process between a plurality of entities that are clients of the distributed ledger network, the net transmission process corresponding to the one or more transmissions written to the one or more new blocks.

Abstract: The disclosure relates to compounds specific for IL23A and TNF-alpha, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells, and methods of production related to the compounds and compositions are also disclosed.

Abstract: The invention provides antigen binding domains that bind human leukocyte antigen G (HLA-G) protein comprising the antigen binding domains that bind HLA-G, polynucleotides encoding them, vectors, host cells, methods of making and using them.

Abstract: Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.

Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.

Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.

Abstract: Conventional systems fail to recommend covenants in processes at financial institutions, and such systems rely on an underwriter who decides the covenants based on his experience without considering experience of other underwriters and similar type of customers historical records. Embodiments of the present disclosure provides systems and methods that implement data exploration analysis on received input data for categorizing covenants into various categories and training various machine learning models. The trained machine learning models are applied on test data for predicting covenants along with a probability score (e.g., also referred as optimized, unbiased set of covenants). The predicted covenants of various categories are then sorted to obtain a prioritized list of covenants for recommendation.

Abstract: According to some embodiments, the disclosed systems and methods provide non-native functionality to a distributed network for administrative customizations and control of network-hosted and/or blockchain-related application program interfaces (APIs). The disclosed technology provides novel techniques and mechanisms for administrating and/or configuring microservice API requests, whereby customized definitions, operations and executable instructions may cause and/or otherwise have associated information stored in a distributed ledger (e.g., blockchain). In some embodiments, the disclosed functionality and capabilities provided by the disclosed framework enable capabilities for API administration and configuration respective to how workflows of microservices are hosted, executed and stored within and respective to data structures and nodes of a blockchain.

Abstract: A system having at least one processor of a distributed common entity platform, wherein the at least one processor is configured to perform steps to receive a transfer instruction associated with a transfer of a quantity of an asset from a sending entity platform to a receiving entity platform; execute a transfer manager self-executing programming object (SEPO) in response to a first function identifier to execute transfer management operations on a distributed ledger, managed by the distributed common entity platform; wherein the transfer management operations comprise executing an address SEPO in response to a second function identifier of a second instruction to execute address verification operations on the distributed ledger; minting at least one token in a sending wallet associated with the sending wallet address, wherein the at least one token comprises a tokenized version of the quantity of the asset based at least in part on the asset identifier and the quantity value, and transferring the at least o

Abstract: Methods of preparing an electrochemically active material can include providing electrochemically active particles, coating the particles with a binder, and exposing the particles to a source of metal. The methods can also include forming metal salt on the surface of the particles from the source of metal and heating the metal salt to form metal oxide coated particles.

Abstract: Systems and methods utilizing water soluble (aqueous) PAA-based polymer binders for silicon-dominant anodes may include an electrode coating layer on a current collector, where the electrode coating layer is formed from silicon and a pyrolyzed water soluble PAA-based polymer blend, wherein the water soluble PAA-based polymer blend comprises PAA and one or more additional water-soluble polymer components. The electrode coating layer may include more than 70% silicon and the anode may be in a lithium ion battery.