Abstract: A technique for composing a virtual desktop associated with one or more applications in a virtualized computing environment. The technique includes generating file system level metadata in the desktop image for applications that create a perception that data blocks in the desktop image have been allocated to applications, but not actually copying any of the application data into the allocated blocks. Instead, the technique builds a mapping table between disk block numbers and the application data, which can be stored in a separate application store. The disclosed techniques provide a more efficient way to compose a virtual desktop, compared to current virtual desktop adoption techniques.

Abstract: A disc brake includes a brake disc, a sliding caliper, a single piston, and a brake pad carrier comprising a leading part and a trailing part. The brake pad carrier includes mounting features for securing the brake pad carrier to an associated structure of a vehicle. The mounting features define a mounting side and a non-mounting side of the brake. A mounting side brake pad comprises mounting side friction material and a non-mounting side brake pad comprising non-mounting side friction material. The center of pressure of the non-mounting side friction material is circumferentially aligned with the piston and the center of pressure of the mounting side friction material is offset in relation to the piston towards the leading part of the brake pad carrier.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases.

Abstract: A disc brake assembly includes a brake pad having a first pad abutment spaced from a second pad abutment and a third pad abutment positioned between the first pad abutment and the second pad abutment. An actuator is operable to apply a force to the brake pad to apply the brake. The disc brake assembly has a first reaction abutment facing the first pad abutment, a second reaction abutment facing the second pad abutment, and a third reaction abutment facing the third pad abutment. The first, second and third pad abutments are operable to transfer brake pad drag torque to the first, second and third reaction abutments respectively. The disc brake is configured such that under no load conditions with the third pad abutment engaging the third reaction abutment, the first pad abutment is spaced from the first reaction abutment.

Abstract: Among other disclosure, a method includes receiving first electronic content configured for displaying a first page in a browser, the first electronic content including a document object model for the first page. Content in the document object model is identified as corresponding to at least one advertisement on the first page, the first page further including page content. Information is extracted from the identified content to be used in identifying an advertising network system that the advertisement links to. An identity of the advertising network system is determined using the extracted information. Second electronic content is generated using the first electronic content and the determined identity of the advertising network system. A second page including the page content of the first page and the advertisement is generated and displayed. On the second page the advertisement is labeled with the determined identity of the advertising network system.

Abstract: Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases.

Abstract: A multilayered formable packaging film and a method of manufacturing the film are disclosed. The film is suitable for making blisters either by thermoforming or cold forming. The visible surface of the film has unique features preventing counterfeiting, which features are retained on the film even after blister formation. The film has a thickness not exceeding 1050 microns. The film substrate has a 10-500 micron thickness, is devoid of plasticizer and comprises at least one polymeric resin. A coat of an ester acrylic based primer having a 0.1-1 micron thickness is on a first surface of the substrate. A metallized layer with non-uniform thickness between 0.001 to 0.3 micron is deposited on the coat and embossed. A base having a thickness of 50-1000 microns is on the second surface, the base comprising at least one polymeric resin.

Abstract: A disc brake includes an actuation mechanism, and first and second brake pad mounting structures to be located, in use, adjacent opposing inboard and outboard faces, respectively, of a brake rotor to be braked. The disc brake further includes first and second brake pads located by the first and second mounting structures, respectively, such that upon application of the actuation mechanism, the brake pads clamp the brake rotor, and brake torque is reacted by the brake pad mounting structures. The first brake pad has a different functional requirement to the second brake pad such that fitment of the first brake pad in the second brake pad mounting structure and/or the second brake pad in the first brake pad mounting structure impairs the safety, functionality or durability of the brake.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ic) wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ic) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ic) in the preparation of medicaments to be applied in such diseases.

Abstract: The way in which Websites are reviewed for use in an advertising network may be improved by (a) accepting a collection including one or more documents, (b) determining whether or not the collection complies with policies of an advertising network, and (c) approving the collection if it was determined that the collection complies with the policies. The collection may be added to the advertising network if the collection is approved such that (e.g., content-targeted) advertisements may be served in association with renderings of documents included in the collection. The collection may be a Website including one or more Webpages. The policy may concern (A) content of the one or more documents of the collection, (B) usability of a Website wherein the collection of one or more documents is a Website including one or more Webpages, and/or (C) a possible fraud or deception on the advertising network or participants of the advertising network by the collection.

Abstract: The way in which Websites are reviewed for use in an advertising network may be improved by (a) accepting a collection including one or more documents, (b) determining whether or not the collection complies with policies of an advertising network, and (c) approving the collection if it was determined that the collection complies with the policies. The collection may be added to the advertising network if the collection is approved such that (e.g., content-targeted) advertisements may be served in association with renderings of documents included in the collection. The collection may be a Website including one or more Webpages. The policy may concern (A) content of the one or more documents of the collection, (B) usability of a Website wherein the collection of one or more documents is a Website including one or more Webpages, and/or (C) a possible fraud or deception on the advertising network or participants of the advertising network by the collection.

Abstract: A disc brake includes an actuation mechanism, and first and second brake pad mounting structures to be located, in use, adjacent opposing inboard and outboard faces, respectively, of a brake rotor to be braked. The disc brake further includes first and second brake pads located by the first and second mounting structures, respectively, such that upon application of the actuation mechanism, the brake pads clamp the brake rotor, and brake torque is reacted by the brake pad mounting structures. The first brake pad has a different functional requirement to the second brake pad such that fitment of the first brake pad in the second brake pad mounting structure and/or the second brake pad in the first brake pad mounting structure impairs the safety, functionality or durability of the brake.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases.

Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ic) wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ic) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ic) in the preparation of medicaments to be applied in such diseases.

Abstract: The way in which Websites are reviewed for use in an advertising network may be improved by (a) accepting a collection including one or more documents, (b) determining whether or not the collection complies with policies of an advertising network, and (c) approving the collection if it was determined that the collection complies with the policies. The collection may be added to the advertising network if the collection is approved such that (e.g., content-targeted) advertisements may be served in association with renderings of documents included in the collection. The collection may be a Website including one or more Webpages. The policy may concern (A) content of the one or more documents of the collection, (B) usability of a Website wherein the collection of one or more documents is a Website including one or more Webpages, and/or (C) a possible fraud or deception on the advertising network or participants of the advertising network by the collection.

Abstract: A Restorable Vehicle Occupant Safety System to replace present pyrotechnic airbag systems. The system is comprised of an air pressure storage vessel 21 that is fluidly connected to an air distribution manifold 36, electronic sensors that preclude an impending crash, valves which are sensor activated to inflate airbags for driver, passenger, knee bolster, side impact, and rollover units as well as seatbelt pre-tensioning units. The present system will safely deploy the airbags in a substantially safe increment of time before a crash condition and restore the airbags to their original position in the event the crash condition does not occur.

Abstract: A family of substituted chiral allosteric effectors of hemoglobin is useful for delivering more oxygen to hypoxic and ischemic tissues by reducing the oxygen affinity of hemoglobin in whole blood.