Patents by Inventor Sanjeev Kumar Aavula

Sanjeev Kumar Aavula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of AZD5363 and intermediate used therein
    Patent number: 9879017
    Abstract: There is provided a process for the preparation of AZD5363, or a salt of AZD5363, comprising: (a) the reaction of 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione: or a salt thereof, with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol, or a salt thereof, in the presence of base; and (b) either isolating AZD5363 or isolating AZD5363 as a salt. 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione is provided and is prepared by reacting 4-(alkyloxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid, or a salt thereof, with a cyclizing agent.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: January 30, 2018
    Assignee: AstraZeneca AB
    Inventors: Sanjeev Kumar Aavula, Vinod Kumar Chandukudlu House, Anil Chikkulapalli, Karthikeyan Chinnakalai
  • Processes for the Preparation of AZD5363 and Novel Intermediate Used Therein
    Publication number: 20170210745
    Abstract: There is provided a process for the preparation of AZD5363, or a salt of AZD5363, comprising: (a) the reaction of 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.5]decane-2,4-dione: or a salt thereof, with (S)-3-amino-3-(4-chlorophenyl)propan-1-ol, or a salt thereof, in the presence of base; and (b) either isolating AZD5363 or isolating AZD5363 as a salt. 8-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-oxa-1,8-diazaspiro[4.
    Type: Application
    Filed: May 26, 2015
    Publication date: July 27, 2017
    Applicant: AstraZeneca AB
    Inventors: Sanjeev Kumar Aavula, Vinod Kumar Chandukudlu House, Anil Chikkulapalli, Karthikeyan Chinnakalai
  • PROCESS FOR PREPARATION OF SOLID MONTELUKAST
    Publication number: 20100063291
    Abstract: A process for preparation of montelukast or a salt thereof is provided, the process including reacting a late intermediate compound which is 2-[1-[1-R-3-[2-(7 chloro quinolin-2-yl)vinyl [phenyl]-3-[2-methoxy carbonyl phenyl]propyl sulfonyl methyl]cyclo propyl]acetic acid or a salt thereof with methyl magnesium chloride or methyl magnesium bromide in an organic solvent. In one embodiment, the process includes reacting an earlier intermediate compound which is methyl 2-(3-R-(3-(2-(7-chloro 2-quinolinyl)-ethenyl)-3 hydroxy propyl)benzoate with methane sulfonyl chloride or toluene sulfonyl chloride to obtain a mesylated or tosylated derivative of the earlier intermediate compound; followed by a reaction of the mesylated or tosylated derivative with 1-mercapto methyl cyclopropane acetic acid in a polar solvent in a presence of a base to obtain the late intermediate compound.
    Type: Application
    Filed: November 17, 2009
    Publication date: March 11, 2010
    Applicants: DR. REDDY'S LABORATORIES, INC., DR. REDDY'S LABORATORIES LIMITED
    Inventors: Buchi Reddy Reguri, Satyanarayana Bollikonda, Veera Venkata Naga Chandra Sekhar Bulusu, Ravi Kumar Kasturi, Sanjeev Kumar Aavula
  • Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
    Patent number: 7189853
    Abstract: The present invention is related to a process for preparing montelukast involving the compound of formula (VI): wherein X?CN or CONH2.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: March 13, 2007
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Venkataraman Sundaram, Srinivasan Thirumalai Rajan, Veera Venkata Naga Chandra Sekhar Bulusu, AlokKumar Srivastav, Ravi Kumar Kasturi, Sanjeev Kumar Aavula