Abstract: The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Abstract: Optical networks, network elements, and methods of use are described herein, including an optical network comprising head-end and tail-end network elements, an optical multiplex section (OMS) connecting the head-end and tail-end network elements, and one or more intermediate line amplifiers in the OMS between the head-end and tail-end network elements. The head-end network element may store first information indicative of a first tilt control section having the head-end and tail-end network elements as endpoints; determine information indicative of a change in topology of the OMS, such as that a first intermediate line amplifier has switched from a non-monitoring to a monitoring mode; and store second information indicative of a second tilt control section having the head-end network element and a new tail-end network element, such as the first intermediate line amplifier.

Abstract: An orchestration adapter of an optical network is herein described.

Abstract: Disclosed herein are methods and systems for correcting power excursions. One exemplary network element may be provided with a processor; a first line port; a flexible ROADM module including a wavelength selective switch, a multiplexer, and one or more control block; a second line port; and a memory storing an orchestrator application and processor-executable instructions. Responsive to receiving a first signal indicative of an impending network state change, the processor-executable instructions cause the processor to pause all power adjustments by the control block on the flexible ROADM module and save at least one power set point value for each active passband from a first optical signal multiplexed into a second optical signal; and responsive to receiving a second signal indicative of the network state change, adjust an optical power of each active passband from the first optical signal multiplexed into the second optical signal using the power set point values.

Abstract: Disclosed herein are methods and systems for configuring a spectral loading pattern for a transmission line segment in an optical network, the method comprising obtaining at least one loading policy, activating at least one of the at least one loading policy, receiving a plurality of requested operations, obtaining one or more static datapoint and one or more dynamic datapoint associated with the transmission line segment, obtaining loading parameters and one or more loading algorithm from the at least one activated loading policy, generating a loading response according to the one or more loading algorithm, and changing a spectral loading pattern of the transmission line segment based on the loading response. The requested operations may identify operations to be executed in either of a current cycle or one or more subsequent cycle. The loading response may identify a subset of the operations to be executed in the current cycle.

Abstract: An optical network and a method of use are herein disclosed. The method comprises: receiving, by a DEMUX module of a local ROADM, a request from an upstream ROADM, the upstream ROADM being upstream from the local ROADM on a fiber optic line, the local ROADM comprising the DEMUX module and first and second MUX modules, the request including first instructions to perform an operation on the local ROADM; sending, by the DEMUX module, a distributed request to the first and second MUX modules, the distributed request including second instructions to perform the operation on the first and second MUX modules; attempting, by the first and second MUX modules, to perform the operation; and sending a consolidated response to the upstream ROADM indicative of one of a success and a failure of performing the operation on the first and second MUX modules.

Abstract: Networks and network elements having a service and power control orchestrator are disclosed, including a network element comprising a processor; a first port coupled to a first optical link carrying a first optical signal; a WSS having a multiplexer, a demultiplexer, and a control block operable to control the multiplexer/demultiplexer. The WSS operable to switch the first optical signal into a second optical signal. A second port is coupled to a second optical link, operable to carry the second optical signal, and in optical communication with the WSS. A memory stores an orchestrator application, an OTSA component, a service component, and instructions that cause the processor to: store a logical ROADM model having a connectivity matrix of the network element; receive a communication associated with the control block based on the logical ROADM model; and transmit, to the control block, a service loading sequence based on the logical ROADM model.

Abstract: A system and method are described herein. The system comprises a wavelength selective switch having a minimum passband width; a processor; and a memory storing a datastore and processor-executable instructions that when executed cause the processor to: receive a connection request comprising an optical channel; determine an affinity group ID of an affinity group associated with the requested optical channel, the affinity group being associated with two or more adjacent optical channels having a combined channel width equal to or greater than the minimum passband width; create a loading group based on the two or more adjacent optical channels associated with the affinity group; receive a loading request to load the optical channel associated with the affinity group; and in response to receiving the loading request, load the two or more adjacent optical channels associated with the affinity group.

Abstract: Disclosed herein are methods and systems involving an event scheduler sub-system configured for aggregation, prioritization, and serialization of software application events, including a method comprising receiving event and associated event data; determining event type and event object key; storing the event data in an event handler data table; generating a priority group number and an insertion order number associated with the event; generating a new queue element comprising the priority group number, the insertion order number, a reference to the event handler, the object key, and the event type; inserting the new queue element to an event scheduler priority queue; sending a signal from the event handler to the event scheduler indicating availability of the new queue element to process; retrieving the event data associated with a queue element with a highest priority in the priority queue; and passing the event data to an admin application for processing.

Abstract: An optical network and a method of use are herein disclosed. The optical network comprises a fiber optic line, two or more ROADMs, and an orchestrator comprising a processor and a non-transitory computer-readable medium storing processor-executable instructions that, when executed, cause the processor to: receive an operation to execute, the operation being a loading of a first optical service on the fiber optic line by a local ROADM; determine a status of a downstream ROADM as being available; reserve the downstream ROADM for the loading of the first optical service by preventing the downstream ROADM from loading a second optical service on the fiber optic line and disabling one or more control block of the downstream ROADM, thereby preventing the one or more control block from adjusting a configuration of the downstream ROADM; and load the first optical service on the fiber optic line.

Abstract: Disclosed herein are methods and systems for generating and/or obtaining at least one loading policy for a transmission line segment that is currently operating, the at least one loading policy comprising a combination of loading parameters for one or more types of loading management operations associated with the transmission line segment. At least one of the loading policies may be activated on a network element of the transmission line segment. Upon receiving a loading request to change a spectral loading pattern of the transmission line segment, current loading data of the transmission line segment and loading parameters from the activated loading policy may be obtained and used to generate a loading response. A signal containing the loading response may be sent to the network element, the signal configured to cause the network element to change the spectral loading pattern of the transmission line segment based on the loading response.

Abstract: A transport network, a node, and a method are disclosed. The transport network, the node, and the method detect a failure of a super channel originating from a sliceable light source that is routed through the transport network, by detecting an optical loss of signal by an optical power monitoring device, in presence or absence of an optical loss of signal of the complete band by at least one photo detector. This information is analyzed with a fault detection algorithm using a patch cable network configuration to determine a fault indication for a failure within the first node. The fault signal indicative of the fault indication is then passed to another node on the first path.

Abstract: A system and method is disclosed in which circuitry of a first controller of a first node on a first path within a transport network receives a first signal indicating a failure within the first path from a second controller. The first node is an end node of the first path. A first client signal failure clear signal is received from a second node upstream of the first node on the first path. The first client signal failure clear signal indicates that a non-restorable fault has been resolved such that the first path can be considered for carrying data traffic. The non-restorable fault is a failure at the source. Subsequent to receiving the first signal indicating the failure within the first path, a backward defect indication clear signal is transmitted to the second node, the backward defect indication clear signal indicating an absence of a failure in the first path.

Abstract: Systems and methods are described in which circuitry of a first controller of a first node receives a first signal indicating an optical loss of signal within the first path. Circuitry of a second controller of the first node on the first path within a transport network generates a second signal indicating a failure within the first path. The first controller accessing a network topology database determines that restoration of the first path would be ineffective due to there being no alternate path, and signals a second node downstream in the first path with the second signal indicating the failure within the first path, and a third signal indicating that restoration of the first path would be ineffective due to there being no alternate path.

Abstract: Methods, nodes and control modules are disclosed. In the method, circuitry of a first node in a mesh network converts an optical layer in a working path between the first node and a second node, to a data stream in a digital layer. The working path carries data traffic from the first node to the second node in the optical layer of the mesh network when there is no failure in the working path. Circuitry of the first node in the mesh network detects a failure in the working path due to detection of an error in the data stream in the digital layer. The circuitry of the first node establishes, through transmission of at least one signal from the first node to the second node, a restoration path in the optical layer based on, at least in part, detection of the error in the data stream in the digital layer.

Abstract: A transport network, a node, and a method are disclosed. The transport network, the node, and the method detect a failure of a super channel originating from a sliceable light source that is routed through the transport network, by detecting an optical loss of signal by an optical power monitoring device, in presence or absence of an optical loss of signal of the complete band by at least one photo detector. This information is analyzed with a fault detection algorithm using a patch cable network configuration to determine a fault indication for a failure within the first node. The fault signal indicative of the fault indication is then passed to another node on the first path.

Abstract: A system and method is disclosed in which circuitry of a first controller of a first node on a first path within a transport network receives a first signal indicating a failure within the first path from a second controller. The first node is an end node of the first path. A first client signal failure clear signal is received from a second node upstream of the first node on the first path. The first client signal failure clear signal indicates that a non-restorable fault has been resolved such that the first path can be considered for carrying data traffic. The non-restorable fault is a failure at the source. Subsequent to receiving the first signal indicating the failure within the first path, a backward defect indication clear signal is transmitted to the second node, the backward defect indication clear signal indicating an absence of a failure in the first path.

Abstract: Embodiments include methods and apparatuses for providing at least one signaling indication of a super-channel by a power controller in a Wavelength Division Multiplexing (WDM) system. The power controller may receive a service provisioning and a lock state from a network management entity. The power controller may receive, from an optical fabric unit, a fabric state that indicates whether a pass-band of the super-channel is provisioned. The power controller may receive the power level of the super-channel from a power monitoring unit. Based on the power level and attenuation level of the super-channel, the power controller may determine a ramp state that indicates whether the power level reached to a predetermined power. The power controller may determine an alarm state based on the power level. The power controller may determine the signaling indication based on the service provisioning, lock, fabric, ramp, and alarm states.

Abstract: Systems and methods are described in which circuitry of a first controller of a first node receives a first signal indicating an optical loss of signal within the first path. Circuitry of a second controller of the first node on the first path within a transport network generates a second signal indicating a failure within the first path. The first controller accessing a network topology database determines that restoration of the first path would be ineffective due to there being no alternate path, and signals a second node downstream in the first path with the second signal indicating the failure within the first path, and a third signal indicating that restoration of the first path would be ineffective due to there being no alternate path.

Abstract: Methods, nodes and control modules are disclosed. In the method, circuitry of a first node in a mesh network converts an optical layer in a working path between the first node and a second node, to a data stream in a digital layer. The working path carries data traffic from the first node to the second node in the optical layer of the mesh network when there is no failure in the working path. Circuitry of the first node in the mesh network detects a failure in the working path due to detection of an error in the data stream in the digital layer. The circuitry of the first node establishes, through transmission of at least one signal from the first node to the second node, a restoration path in the optical layer based on, at least in part, detection of the error in the data stream in the digital layer.