Patents by Inventor Sankar Ghosh

Sankar Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10308603
    Abstract: This invention relates to an improved process for the selective production of N-methyl pyrrolidone (NMP) from gamma-butyrolactone and monomethyl amine preferably in aqueous form in the presence of a catalyst under comparatively milder conditions than the processes well known in the prior art of literature. The process is economically viable as it provides higher yield and selectivity for NMP which reduces the cost of separation of NMP from GBL. The catalyst shows good recyclability without significant loss in catalytic activity and no frequent regeneration is required.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: June 4, 2019
    Assignee: Council of Scientific & Industrial Research
    Inventors: Indrajit Kumar Ghosh, Suman Lata Jain, Praveen Kumar Khatri, Siddharth Sankar Ray, Madhukar Onkarnath Garg
  • Publication number: 20190046988
    Abstract: A device with integrated methods for carrying out reverse transcription polymerase chain reaction (RT-PCR) and/or array based analysis involving signal generating agents (gold nanoclusters) comprising a heating and cooling cycle based synthesis selectively with DIMA and protein as templates. The advancement is further directed to a portable device adapted for RT-PCR and array based gene and protein expression analyses based on a common detection agent involving luminescence of in-situ synthesized gold nanoclusters with adaptability for user friendly graphical user interface (GUI) for controlling, visualization and analysis of the data.
    Type: Application
    Filed: June 2, 2016
    Publication date: February 14, 2019
    Inventors: Arun CHATTOPADHYAY, Sunil Kumar SAILAPU, Deepanjalee DUTTA, Amaresh Kumar SAHOO, Siddhartha Sankar GHOSH
  • Publication number: 20180319886
    Abstract: Methods of treating a PD-1-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a PD-1 inhibitor. A pharmaceutical combination comprising a therapeutically effective amount of a c-Rel inhibitor, and a therapeutically effective amount of a PD-1 inhibitor is also provided. Finally, methods of treating a cancer such as a CTLA-4-resistant cancer, a CD137-resistant cancer, and an OX-4-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel inhibitor and a therapeutically effective amount of a CLTA-4, CD137 or OX-4 inhibitor, respectively.
    Type: Application
    Filed: September 28, 2016
    Publication date: November 8, 2018
    Inventors: Sankar GHOSH, Yenkel GRINBERG-BLEYER
  • Publication number: 20140296154
    Abstract: The present invention relates to a method of inhibiting onset of or preventing development of a psoriatic lesion in a patient having psoriasis. The method comprises administering to a patient having psoriasis an effective amount of an agent that inhibits NF-?B activity under conditions effective to inhibit onset of or prevent development of psoriatic lesions. Another aspect of the invention relates to a method of treating an early stage psoriatic lesion on a patient by contacting the early stage psoriatic lesion of a patient with an effective amount of an agent that inhibits NF-?B activity, whereby said contacting inhibits development of the early stage psoriatic lesion. Both transgenic and nontransgenic approaches are contemplated.
    Type: Application
    Filed: May 7, 2012
    Publication date: October 2, 2014
    Applicants: YALE UNIVERSITY, UNIVERSITY OF ROCHESTER
    Inventors: Brian Poligone, Sankar Ghosh
  • Patent number: 8422130
    Abstract: A portable magnifying instrument useful for colposcopy is provided which may include in combination an optical system capable of providing a distortion free clear continuously varying 10× to 15× magnification of a three-dimensional wide object; an integrated energy efficient, low powered and intensity controlled illumination system; a power pack and mounting. The optical system may have an eyepiece lens system and an objective lens system. The illumination system may have a plurality of light emitting diodes (LEDs) connected to the power pack; mounted in such a manner that the angle between the LEDs is maintained with respect to the optical axis of the lens system and that the light beam from the said LEDs impinges on the wide object to be observed at the focus of the said lens system.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: April 16, 2013
    Assignee: Council of Scientific & Industrial Research
    Inventors: Uday Sankar Ghosh, Tapas Gangopadhyay, Munshi Amirul Alam, Sankar Karmakar, Mihir Kumar Banerjee, Gour Chandra Chatterjee
  • Publication number: 20120329720
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Application
    Filed: June 29, 2012
    Publication date: December 27, 2012
    Applicant: YALE UNIVERSITY
    Inventors: Michael J. May, Sankar Ghosh, Mark A. Findeis, Kathryn Phillips, Gerhard Hannig
  • Patent number: 8242240
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: August 14, 2012
    Assignee: Yale University
    Inventors: Michael J. May, Sankar Ghosh, Mark A. Findeis, Kathryn Phillips, Gerhard Hannig
  • Patent number: 8217138
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: July 10, 2012
    Assignee: Yale University
    Inventors: Michael J. May, Sankar Ghosh
  • Publication number: 20120101028
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Application
    Filed: August 8, 2011
    Publication date: April 26, 2012
    Applicant: Yale University
    Inventors: Michael J. May, Sankar Ghosh
  • Patent number: 8017726
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: September 13, 2011
    Assignee: Yale University
    Inventors: Michael J. May, Sankar Ghosh
  • Publication number: 20110160119
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Application
    Filed: December 2, 2010
    Publication date: June 30, 2011
    Applicant: YALE UNIVERSITY
    Inventors: Michael J. May, Sankar Ghosh
  • Publication number: 20110071092
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Application
    Filed: August 27, 2010
    Publication date: March 24, 2011
    Applicant: YALE UNIVERSITY
    Inventors: Michael J. May, Sankar Ghosh, Mark A. Findeis, Kathryn Phillips, Gerhard Hannig
  • Patent number: 7905410
    Abstract: An automated tunnel-type scanning system arranged about a conveyor belt structure, including: a tunnel structure arranged about a conveyor belt structure for transporting packages; an omni-directional bar code symbol scanning subsystem; a package detection and dimensioning subsystem; and a data management subsystem. The package detection and dimensioning subsystem captures package measurement information about each detected package prior to the package being scanned by the omni-directional bar code symbol reading subsystem, and producing package measurement data representative of the captured package measurement information.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: March 15, 2011
    Assignee: Metrologic Instruments, Inc.
    Inventors: Timothy A. Good, Andrew D. Dehennis, Xiaoxun Zhu, David M. Wilz, Sr., George B. Rockstein, Stephen J. Colavito, Robert E. Blake, Ka Man Au, George Kolis, C. Harry Knowles, Sankar Ghosh, Ian A. Scott, Thomas Amundsen, Gennady Germaine, LeRoy Dickson
  • Patent number: 7872094
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: January 18, 2011
    Assignee: Yale University
    Inventors: Michael J. May, Sankar Ghosh
  • Patent number: 7832643
    Abstract: A hand-supportable planar laser illumination and imaging (PLIIM) based code symbol reader includes: a hand-supportable housing having light transmission aperture; a linear image formation and detection module having a linear image detection array; and a planar laser illumination beam (PLIB) producing device having at least one visible laser diode (VLD) for producing a planar light illumination beam (PLIB). The code symbol reader further includes image grabber for grabbing digital linear images formed and detected by the image formation and detection module, an image data buffer for buffering the digital linear images grabbed by the image grabber and constructing a two-dimensional image from a series of buffered linear digital images, and an image processing computer for processing the buffered two-dimensional digital image so as to read code symbols graphically represented in the two-dimensional digital linear image.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: November 16, 2010
    Assignee: Metrologic Instruments, Inc.
    Inventors: Constantine J. Tsikos, C. Harry Knowles, Xiaoxun Zhu, Michael D. Schnee, Ka Man Au, Allan Wirth, Timothy A. Good, Andrew Jankevics, Sankar Ghosh, Charles A. Naylor, Thomas Amundsen, Robert Blake, William Svedas, Shawn Defoney, Edward Skypala, Pirooz Vatan, Russell Joseph Dobbs, George Kolis, Mark C. Schmidt, Jeffery Yorsz, Patrick A. Giordano, Stephen J. Colavito, David W. Wilz, Sr., Barry E. Schwartz, Steven Y. Kim, Dale Fisher, Jon Van Tassell
  • Patent number: 7812118
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: October 12, 2010
    Assignee: Yale University
    Inventors: Michael J. May, Sankar Ghosh, Mark A. Findeis, Kathryn Phillips, Gerhard Hannig
  • Patent number: 7673803
    Abstract: A planar laser illumination and imaging (PLIIM) based engine including; an engine housing having light transmission aperture; an image formation and detection module and having an image detection array and image formation optics with a field of view (FOV) extending from the image detection array, through the light transmission aperture and onto an object moving relative to the engine housing during object illumination and imaging operations; a planar laser illumination beam (PLIB) producing device, and having at least one visible laser illumination source arranged in relation to the image formation and detection module, for producing a planar light illumination beam (PLIB), and projecting the planar light illumination beam through light transmission aperture and oriented such that the plane of the PLIB is coplanar with the field of view of the image formation and detection module so that the object can be simultaneously illuminated by the planar light illumination beam and imaged within the field of view and
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: March 9, 2010
    Assignee: Metrologic Instruments, Inc.
    Inventors: Constantine J. Tsikos, C. Harry Knowles, Xiaoxun Zhu, Michael D. Schnee, Ka Man Au, Allan Wirth, Timothy A. Good, Andrew Jankevics, Sankar Ghosh, Charles A. Naylor, Thomas Amundsen, Robert Blake, William Svedas, Shawn Defoney, Edward Skypala, Pirooz Vatan, Russell Joseph Dobbs, George Kolis, Mark S. Schmidt, Jeffery Yorsz, Patrick A. Giordano, Stephen J. Colavito, David W. Wilz, Sr., Barry E. Schwartz, Steven Y. Kim, Dale Fisher, Jon Van Tassell
  • Publication number: 20100039700
    Abstract: A portable magnifying instrument useful for colposcopy is provided which may include in combination an optical system capable of providing a distortion free clear continuously varying 10× to 15× magnification of a three-dimensional wide object; an integrated energy efficient, low powered and intensity controlled illumination system; a power pack and mounting. The optical system may have an eyepiece lens system and an objective lens system. The illumination system may have a plurality of light emitting diodes (LEDs) connected to the power pack; mounted in such a manner that the angle between the LEDs is maintained with respect to the optical axis of the lens system and that the light beam from the said LEDs impinges on the wide object to be observed at the focus of the said lens system.
    Type: Application
    Filed: March 3, 2008
    Publication date: February 18, 2010
    Inventors: Uday Sankar Ghosh, Tapas Gangopadhyay, Mundshi Amirul Alam, Sankar Karmakar, Mihir Kumar Banerjee, Gour Chandra Chatterjee
  • Publication number: 20090286736
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Application
    Filed: April 15, 2009
    Publication date: November 19, 2009
    Applicant: YALE UNIVERSITY
    Inventors: MICHAEL J. MAY, SANKAR GHOSH
  • Publication number: 20090286748
    Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.
    Type: Application
    Filed: April 9, 2009
    Publication date: November 19, 2009
    Applicant: Yale University
    Inventors: Michael J. May, Sankar Ghosh, Mark A. Findeis, Kathryn Phillips, Gerhard Hannig