Patents by Inventor Sankaranarayanan Srinivasan
Sankaranarayanan Srinivasan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11853662Abstract: A method includes storing a base model generated using base data and receiving training data generated by compiling circuit designs. The method also includes generating, using the training data, a tuned model and generating, using the training data and the base data, a hybrid model. The method further includes receiving a selected cost function and biasing the base model, the tuned model, and the hybrid model using the selected cost function.Type: GrantFiled: June 21, 2022Date of Patent: December 26, 2023Assignee: Synopsys, Inc.Inventors: Sankaranarayanan Srinivasan, Senthilkumar Thoravi Rajavel, Vinod Kumar Nakkala, Avinash Anantharamu, Pierre Clement, Saibal Ghosh, Sashikala Oblisetty, Etienne Lepercq
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Patent number: 11548937Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.Type: GrantFiled: July 6, 2020Date of Patent: January 10, 2023Assignee: Zumutor Biologics Inc.Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B. M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
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Patent number: 11549119Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.Type: GrantFiled: April 6, 2017Date of Patent: January 10, 2023Assignee: ZUMUTOR BIOLOGICS, INC.Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma, Rashmi Sharma, Anurag Tiwari, Santosh Kumar, Shivani Patel, Nikitha M
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Publication number: 20220318468Abstract: A method includes storing a base model generated using base data and receiving training data generated by compiling circuit designs. The method also includes generating, using the training data, a tuned model and generating, using the training data and the base data, a hybrid model. The method further includes receiving a selected cost function and biasing the base model, the tuned model, and the hybrid model using the selected cost function.Type: ApplicationFiled: June 21, 2022Publication date: October 6, 2022Inventors: Sankaranarayanan SRINIVASAN, Senthilkumar THORAVI RAJAVEL, Vinod Kumar NAKKALA, Avinash ANANTHARAMU, Pierre CLEMENT, Saibal GHOSH, Sashikala OBLISETTY, Etienne LEPERCQ
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Patent number: 11384354Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.Type: GrantFiled: December 21, 2015Date of Patent: July 12, 2022Assignee: ZUMUTOR BIOLOGICS INC.Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Anurag Tiwari, Santosh Kumar, Shivani Patel, Nikitha M
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Patent number: 11366948Abstract: A method includes generating a netlist for a circuit design and predicting, by applying a first machine learning model to the netlist, a first compile time for the circuit design. The method also includes predicting, by applying a second machine learning model to the netlist, a first place and route strategy based on the first compile time. The method further includes adjusting a logic of the circuit design in accordance with the first place and route strategy.Type: GrantFiled: August 13, 2020Date of Patent: June 21, 2022Assignee: Synopsys, Inc.Inventors: Sankaranarayanan Srinivasan, Senthilkumar Thoravi Rajavel, Vinod Kumar Nakkala, Avinash Anantharamu, Pierre Clement, Saibal Ghosh, Sashikala Oblisetty, Etienne Lepercq
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Patent number: 11267899Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.Type: GrantFiled: May 13, 2016Date of Patent: March 8, 2022Assignee: Zumutor Biologics Inc.Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Jahnabi Hazarika, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma
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Patent number: 11230706Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.Type: GrantFiled: January 19, 2017Date of Patent: January 25, 2022Assignee: ZUMUTOR BIOLOGICS, INC.Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Maliwalave Amol, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma, Rashmi Sharma, Anurag Tiwari, Santosh Kumar, Shivani Patel, Nikitha Markanda
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Publication number: 20210117601Abstract: A method includes generating a netlist for a circuit design and predicting, by applying a first machine learning model to the netlist, a first compile time for the circuit design. The method also includes predicting, by applying a second machine learning model to the netlist, a first place and route strategy based on the first compile time. The method further includes adjusting a logic of the circuit design in accordance with the first place and route strategy.Type: ApplicationFiled: August 13, 2020Publication date: April 22, 2021Inventors: Sankaranarayanan SRINIVASAN, Senthilkumar THORAVI RAJAVEL, Vinod Kumar NAKKALA, Avinash ANANTHARAMU, Pierre CLEMENT, Saibal GHOSH, Sashikala OBLISETTY, Etienne LEPERCQ
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Publication number: 20200339666Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.Type: ApplicationFiled: July 6, 2020Publication date: October 29, 2020Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B.M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
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Publication number: 20200283757Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a human naïve antibody gene expression library encompassing a pool of nucleic acid sequences derived from a natural antibody repertoire comprising humoral immunity from healthy and genetically diverse human populations. More specifically, the method employs a combination of phage and/or yeast antibody surface display concept which allows to screen large antibody library size and facilitates better folding of antibody structure. The present disclosure also relates to a human naïve antibody library generated by employing the process of the present disclosure, a set of primers employed in the method and application(s) of said antibody library.Type: ApplicationFiled: December 21, 2015Publication date: September 10, 2020Inventors: Sohang CHATTERJEE, Kavitha Iyer RODRIGUES, Maloy GHOSH, Sunit MAITY, Divya UNNIKRISHNAN, Yogendra Manjunath BANGALORE MUNIRAJU, Sathyabalan MURUGESAN, Pavithra MUKUNDA, Bhargav PRASAD, Veeresha KAMANAGOWDA, Sanghamitra BHATTACHARJEE, Pravin Kumar DAKSHINAMURTHY, Vivek HALAN, Sankaranarayanan SRINIVASAN, Anuradha HORA, Bairavabalakumar NATARAJAN, Karthika NAIR, Aswini THANIGAIVEL, Amol MALIWALAVE, Bharath Ravindra SHENOY, Sahana Bhima RAO, Subhra Prakash CHAKRABARTY, Ashvini Kumar DUBEY, Amir KHAN, Anurag TIWARI, Santosh KUMAR, Shivani PATEL, Nikitha M
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Patent number: 10752674Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.Type: GrantFiled: November 13, 2015Date of Patent: August 25, 2020Assignee: Zumutor Biologics Inc.Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B. M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
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Publication number: 20200149032Abstract: The present disclosure relates to a method of generating an antibody library, not limiting to a synthetic antibody gene expression library built on pool of consensus nucleic acid sequences by using codon replacement technology. The present disclosure also relates to a synthetic antibody library generated by employing the method of the present disclosure and application(s) of said antibody library.Type: ApplicationFiled: January 19, 2017Publication date: May 14, 2020Inventors: Sohang CHATTERJEE, Kavitha IYER RODRIGUES, Maloy GHOSH, Sunit MAITY, Divya UNNIKRISHNAN, Yogendra MANJUNATH BANGALORE MUNIRAJU, Sathyabalan MURUGESAN, Pavithra MUKUNDA, Bhargav PRASAD, Veeresha KAMANAGOWDA, Sanghamitra BHATTACHARJEE, Pravin KUMAR DAKSHINAMURTHY, Vivek HALAN, Sankaranarayanan SRINIVASAN, Anuradha HORA, Bairavabalakumar NATARAJAN, Karthika NAIR, Aswini THANIGAIVEL, MALIWALAVE Amol, Bharath RAVINDRA SHENOY, Sahana BHIMA RAO, Subhra PRAKASH CHAKRABARTY, Ashvini KUMAR DUBEY, Amir KHAN, Ankurina SHARMA, Rashmi SHARMA, Anurag TIWARI, Santosh KUMAR, Shivani PATEL, Nikitha MARKANDA
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Publication number: 20190119691Abstract: The present disclosure relates to vectors for cloning and expressing genetic material including but not limiting to antibody gene or parts thereof and methods of generating said vectors. Said vectors express the antibody genes in different formats such as Fab or scFv as a part of intertransfer system, intratransfer system or direct cloning and expression in individual display systems. In particular, phage display technology is used to clone and screen potential antibody genes in phagemid which is followed by the transfer of said genes to yeast vector for further screening and identification of lead molecules against antigens. The present vectors have numerous advantages including uniquely designed inserts/expression cassettes resulting in efficient and smooth transfer of clonal population from phage to yeast vectors resulting in efficient library preparation and identification of lead molecules.Type: ApplicationFiled: April 6, 2017Publication date: April 25, 2019Inventors: Sohang CHATTERJEE, Kavitha Iyer RODRIGUES, Maloy GHOSH, Sunit MAITY, Divya UNNIKRISHNAN, Yogendra Manjunath Bangalore MUNIRAJU, Sathyabalan MURUGESAN, Pavithra MUKUNDA, Bhargav PRASAD, Veeresha KAMANAGOWDA, Sanghamitra BHATTACHARJEE, Pravin Kumar DAKSHINAMURTHY, Vivek HALAN, Sankaranarayanan SRINIVASAN, Anuradha HORA, Bairavabalakumar NATARAJAN, Karthika NAIR, Aswini THANIGAIVEL, Amol MALIWALAVE, Bharath Ravindra SHENOY, Sahana Bhima RAO, Subhra Prakash CHAKRABARTY, Ashvini Kumar DUBEY, Amir KHAN, Ankurina SHARMA, Rashmi SHARMA, Anurag TIWARI, Santosh KUMAR, Shivani PATEL, Nikitha M
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Publication number: 20190112358Abstract: The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.Type: ApplicationFiled: November 13, 2015Publication date: April 18, 2019Inventors: Bhargav Prasad, Divya Unnikrishnan, Jahnabi Hazarika, Kavitha Iyer Rodrigues, Maloy Ghosh, Pavithra M, Pravin Kumar D, Sanghamitra Bhattacharjee, Sathyabalan M, Sankaranarayanan Srinivasan, Sohang Chatterjee, Sunit Maity, Veeresha K, Vivek Halan, Yogendra Manjunath B. M., Anuradha Hora, Bairavabalakumar N, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R Shenoy, Rajeshwari Pendse, Prabhat Kumar Pathak, Anisha Kurup, Sahana Bhima Rao
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Patent number: 10077434Abstract: The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.Type: GrantFiled: July 30, 2015Date of Patent: September 18, 2018Assignee: Zumutor Biologics Inc.Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Rajeshwari Pendse, Divya Unnikrishnan, Yogendra Manjunath B. M., Jahnabi Arika, Sathyabalan M., Pavithra M., Bhargav Prasad, Veeresha K., Prabhat Kumar Pathak, Sanghamitra Bhattacharjee, Pravin Kumar D., Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar N., Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R. Shenoy, Anisha Kurup
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Publication number: 20180171028Abstract: The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.Type: ApplicationFiled: May 13, 2016Publication date: June 21, 2018Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Divya Unnikrishnan, Jahnabi Hazarika, Yogendra Manjunath Bangalore Muniraju, Sathyabalan Murugesan, Pavithra Mukunda, Bhargav Prasad, Veeresha Kamanagowda, Sanghamitra Bhattacharjee, Pravin Kumar Dakshinamurthy, Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar Natarajan, Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath Ravindra Shenoy, Sahana Bhima Rao, Subhra Prakash Chakrabarty, Ashvini Kumar Dubey, Amir Khan, Ankurina Sharma
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Publication number: 20170306305Abstract: The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.Type: ApplicationFiled: July 30, 2015Publication date: October 26, 2017Applicant: Zumator Biologics, Inc.Inventors: Sohang Chatterjee, Kavitha Iyer Rodrigues, Maloy Ghosh, Sunit Maity, Rajeshwari Pendse, Divya Unnikrishnan, Yogendra Manjunath B. M., Jahnabi Arika, Sathyabalan M., Pavithra M., Bhargav Prasad, Veeresha K., Prabhat Kumar Pathak, Sanghamitra Bhattacharjee, Pravin Kumar D., Vivek Halan, Sankaranarayanan Srinivasan, Anuradha Hora, Bairavabalakumar N., Karthika Nair, Aswini Thanigaivel, Amol Maliwalave, Bharath R. Shenoy, Anisha Kurup
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Patent number: 8146041Abstract: A computer-implemented method of implementing a circuit design within a programmable logic device can include selecting at least one circuit element of the circuit design. The selected circuit element can be converted to a latch. A timing analysis can be performed upon the circuit design after conversion of the selected circuit element to a latch. A determination can be made by a computer as to whether the timing of the circuit design improves and the conversion of the selected circuit element to a latch can be accepted when the timing of the circuit design improves. The circuit design can be output.Type: GrantFiled: July 12, 2011Date of Patent: March 27, 2012Assignee: Xilinx, Inc.Inventors: Sankaranarayanan Srinivasan, Sridhar Krishnamurthy, Brian D. Philofsky, Kamal Chaudhary, Anirban Rahut
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Patent number: 8141010Abstract: A design hierarchy based on an implementation set abstraction of a user design for an integrated circuit design includes a plurality of nodes and a definition for each of the nodes in the plurality of nodes that describes the type of elements contained in each node and the hierarchy defined by each of the nodes. Each node can include at least one implementation element of the design and the at least one implementation element can be selected among the group including a set of logical elements, a set of placed elements, and a set of placed and routed elements.Type: GrantFiled: February 8, 2008Date of Patent: March 20, 2012Assignee: Xilinx, Inc.Inventors: Raymond Kong, Daniel J. Downs, John J. Laurence, Richard Yachyang Sun, Sankaranarayanan Srinivasan