Patents by Inventor Sankarprasad Bhuniya

Sankarprasad Bhuniya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Flourescent exomarker probes for hydrogen sulfide detection
    Patent number: 10502742
    Abstract: A fluorescence probe with mitochondrial targeting and two-photon property, its preparation method and application in detecting and tracking endogenous H2S in samples or living cells. The fluorescent probe is prepared by a four-step preparation method and demonstrates a UV-vis absorption increment ?ab=395 nm and ˜43 fold higher fluorescence intensity in the presence of H2S. The probe further demonstrates stability, selectivity for H2S over competing agents and sensitivity as low as 20 nm. A method of detecting endogenous H2S rapidly in the absence of any external stimulators is provided. Samples are contacted with the probe and the changes in fluorescence are monitored to detect H2S levels. The disclosed probe is non-toxic and suitable as a biomarker and therapeutic molecule in cancer and other diseases.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: December 10, 2019
    Assignee: AMRITA VISHWA VIDYAPEETHAM
    Inventors: Sankarprasad Bhuniya, Nandita Mishra, Nithya Velusamy, Anupama Binoy, Kondapa Naidu Bobba, Divya Nedungadi
  • FLOURESCENT EXOMARKER PROBES FOR HYDROGEN SULFIDE DETECTION
    Publication number: 20180306792
    Abstract: A fluorescence probe with mitochondrial targeting and two-photon property, its preparation method and application in detecting and tracking endogenous H2S in samples or living cells. The fluorescent probe is prepared by a four-step preparation method and demonstrates a UV-vis absorption increment ?ab=395 nm and ˜43 fold higher fluorescence intensity in the presence of H2S. The probe further demonstrates stability, selectivity for H2S over competing agents and sensitivity as low as 20 nm. A method of detecting endogenous H2S rapidly in the absence of any external stimulators is provided. Samples are contacted with the probe and the changes in fluorescence are monitored to detect H2S levels. The disclosed probe is non-toxic and suitable as a biomarker and therapeutic molecule in cancer and other diseases.
    Type: Application
    Filed: April 18, 2018
    Publication date: October 25, 2018
    Applicant: AMRITA VISHWA VIDYAPEETHAM
    Inventors: SANKARPRASAD BHUNIYA, NANDITA MISHRA, NITHYA VELUSAMY, ANUPAMA BINOY, KONDAPA NAIDU BOBBA, DIVYA NEDUNGADI
  • Uridine-based gadolinium complex and MRI contrast agent including the same
    Patent number: 9290535
    Abstract: The present invention relates to a new uridine nucleoside-based amphiphilic gadolinium complex and a magnetic resonance imaging (MRI) contrast agent including the gadolinium complex. The MRI contrast agent has high relaxivity, high binding affinity for and stability in human serum albumin, pH response, and high liver specificity.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: March 22, 2016
    Assignees: Korea University Researchand Business Foundation, Korea Basic Science Institute
    Inventors: Jong-Seung Kim, Sankarprasad Bhuniya, Sumin Lee, Kwan Soo Hong, Hyunseung Lee, Hyeyoung Moon
  • URIDINE-BASED GADOLINIUM COMPLEX AND MRI CONTRAST AGENT INCLUDING THE SAME
    Publication number: 20140005369
    Abstract: The present invention relates to a new uridine nucleoside-based amphiphilic gadolinium complex and a magnetic resonance imaging (MRI) contrast agent including the gadolinium complex. The MRI contrast agent has high relaxivity, high binding affinity for and stability in human serum albumin, pH response, and high liver specificity.
    Type: Application
    Filed: March 15, 2012
    Publication date: January 2, 2014
    Applicants: KOREA BASIC SCIENCE INSTITUTE, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Jong-Seung Kim, Sankarprasad Bhuniya, Sumin Lee, Kwan Soo Hong, Hyunseung Lee, Hyeyoung Moon