Patents by Inventor Santhosh Francis Neelamkavil

Santhosh Francis Neelamkavil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions of peptide inhibitors of Interleukin-23 receptor
    Patent number: 11939361
    Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: March 26, 2024
    Assignees: Janssen Pharmaceutica NV, Protagonist Therapeutics, Inc.
    Inventors: Giustino Di Pretoro, Dajun Sun, Gopal Rajan, Geraldine Broeckx, Nathalie Mertens, Shu Li, Felix Lai, Mohammad Masjedizadeh, Anne M. Fourie, Beverly Knight, David Polidori, Santhosh Francis Neelamkavil, Nishit Modi, Ashok Bhandari, Xiaoli Cheng
  • C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
    Patent number: 9580396
    Abstract: In its many embodiments, the present invention provides certain C5-spiro iminothiadiazine dioxide compounds, including compounds Formula (I): (structurally represented) or tautomers thereof, and pharmaceutically acceptable salts of said compounds, wherein R1, R2, R3, X, Y, s, ring A, RA, m, -L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: February 28, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jared N. Cumming, Jack D. Scott, Jr., Andrew W. Stamford, Ulrich Iserloh, Santhosh Francis Neelamkavil, Pengcheng Patrick Shao, Jonathan E. Wilson
  • C6-SPIRO IMINOTHIADIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
    Publication number: 20160264538
    Abstract: In its many embodiments, the present invention provides certain C5-spiro iminothiadiazine dioxide compounds, including compounds Formula (I): (structurally represented) or tautomers thereof, and pharmaceutically acceptable salts of said compounds, wherein R1, R2, R3, X, Y, s, ring A, RA, m, -L1-, and RL are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto.
    Type: Application
    Filed: December 16, 2013
    Publication date: September 15, 2016
    Inventors: Jared N. Cumming, Jack D. Scott, JR., Andrew W. Stamford, Ulrich Iserloh, Santhosh Francis Neelamkavil, Pengcheng Patrick Shao, Jonathan E. Wilson
  • Bridged bicyclic piperidine derivatives and methods of use thereof
    Patent number: 9409918
    Abstract: The present invention relates to Bridged Bicyclic Piperidine Derivatives, compositions comprising a Bridged Bi-cyclic Piperidine Derivative, and methods of using the Bridged Bicyclic Piperidine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: August 9, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Joel M. Harris, Andrew Stamford, William J. Greenlee, Santhosh Francis Neelamkavil
  • Pyrimidine ether derivatives and methods of use thereof
    Patent number: 8912206
    Abstract: The present invention relates to Pyrimidine Ether Derivatives, compositions comprising a Pyrimidine Ether Derivative, and methods of using the Pyrimidine Ether Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) in a patient.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: December 16, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Santhosh Francis Neelamkavil, Andrew Stamford, Samuel Chackalamannil, William J. Greenlee
  • Bicyclic heterocycle derivatives and use thereof as GPR119 modulators
    Patent number: 8822480
    Abstract: The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) such as GPR119 in a patient.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: September 2, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Santhosh Francis Neelamkavil, Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Bernard R. Neustadt, Andrew W. Stamford
  • Bicyclic heterocycle derivatives and methods of use thereof
    Patent number: 8815876
    Abstract: The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient. The compounds are of structure (I).
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: August 26, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Santhosh Francis Neelamkavil, Craig D. Boyle, Bernard R. Neustadt, Samuel Chackalamannil, William J. Greenlee
  • PYRIMIDINE ETHER DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20120289525
    Abstract: The present invention relates to Pyrimidine Ether Derivatives, compositions comprising a Pyrimidine Ether Derivative, and methods of using the Pyrimidine Ether Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) in a patient.
    Type: Application
    Filed: November 16, 2010
    Publication date: November 15, 2012
    Inventors: Santhosh Francis Neelamkavil, Andrew Stamford, Samuel Chackalamannil, William J. Greenlee
  • FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20120232073
    Abstract: The present invention relates to Fused Bicyclic Pyrimidine Derivatives, compositions comprising a Fused Bicyclic Pyrimidine Derivative, and methods of using the Fused Bicyclic Pyrimidine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) in a patient.
    Type: Application
    Filed: November 16, 2010
    Publication date: September 13, 2012
    Inventors: Santhosh Francis Neelamkavil, Dipshikha Biswas, Samuel Chackalamannil, Bernard R. Neustadt, Andrew Stamford, Hong Liu
  • BRIDGED BICYCLIC PIPERIDINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20120214805
    Abstract: The present invention relates to Bridged Bicyclic Piperidine Derivatives, compositions comprising a Bridged Bi-cyclic Piperidine Derivative, and methods of using the Bridged Bicyclic Piperidine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
    Type: Application
    Filed: October 28, 2010
    Publication date: August 23, 2012
    Inventors: Joel M. Harris, Andrew Stamford, William J. Greenlee, Santhosh Francis Neelamkavil
  • BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20120040975
    Abstract: The present invention relates to Bridged Bicyclic Heterocycle Derivatives, compositions comprising a Bridged Bicyclic Heterocycle Derivative, and methods of using the Bridged Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.
    Type: Application
    Filed: April 1, 2010
    Publication date: February 16, 2012
    Inventors: Santhosh Francis Neelamkavil, Bernard R. Neustadt, Andrew Stamford, Yan Xia, Joel M. Harris, Craig D. Boyle, Samuel Chackalamannil, Dipshikha Biswas, Hong Liu, Jinsong Hao, Claire M. Lankin, Unmesh Shah
  • BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20110166167
    Abstract: The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient. The compounds are of structure (I).
    Type: Application
    Filed: July 15, 2009
    Publication date: July 7, 2011
    Applicant: Schering Corporation
    Inventors: Santhosh Francis Neelamkavil, Craig D. Boyle, Bernard R. Neustadt, Samuel Chackalamannil, William J. Greenlee
  • BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS
    Publication number: 20110166165
    Abstract: The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) such as GPR119 in a patient.
    Type: Application
    Filed: July 15, 2009
    Publication date: July 7, 2011
    Applicant: Schering Corporation
    Inventors: Santhosh Francis Neelamkavil, Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Bernard R. Neustadt, Andrew W. Stamford
  • BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS GPCR MODULATORS
    Publication number: 20110118286
    Abstract: The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient.
    Type: Application
    Filed: July 15, 2009
    Publication date: May 19, 2011
    Inventors: Santhosh Francis Neelamkavil, Craig D. Boyle, Joel M. Harris, Andre Stamford, Jinsong Hao, Bernard R. Neustadt, Samuel Chackalamannil, Yan Xia, Wiliam J. Greenlee
  • PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20100190687
    Abstract: The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 (“GPR119”) in a patient.
    Type: Application
    Filed: April 17, 2008
    Publication date: July 29, 2010
    Inventors: Craig D. Boyle, Santhosh Francis Neelamkavil, Samuel Chackalamannil, Bernard R. Neustadt, Jinsong Hao, Unmesh G. Shah, Joel M. Harris, Hong Liu, Andrew W. Stamford