Patents by Inventor Santi Tofani

Santi Tofani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11364390
    Abstract: An electromagnetic field generating apparatus for treating pathological cells, in particular with tumor suppression function. The ratio of static magnetic field to alternating magnetic field is in the range of 0.5-2.5, and the total intensity is in the range up to 100 mT. It provides non-invasive low toxicity and side effects, significantly inhibiting a plurality of tumors, influencing the intracellular superoxide radical content, and promoting cell autophagy. The mechanism of action of the magnetic field is on the electron spin energy levels and consequently on free radical concentration. Additional magnetic field having frequency up to 100 MHz and intensity down to microTesla range can be also used to improve the antitumor efficacy in combination with the static as well as the extremely low frequency electromagnetic field (1-300 Hz) influencing the spin hyperfine resonance. A combination method is also provided of a power-frequency electromagnetic field generating device and a platinum-based medicine.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: June 21, 2022
    Assignees: ZHEJIANG UNIVERSITY
    Inventors: Santi Tofani, Xi Chen, Linqing Yuan, Kexin Shi, Chao Yang, Suchen Bian, Jinhu Wang, Kun Zhu, Min Yang, Weizhong Gu, Shiqiang Shang, Huamei Li, Zheng Shen, Can Wang
  • Publication number: 20200016424
    Abstract: An electromagnetic field generating apparatus for treating pathological cells, in particular with tumor suppression function. The ratio of static magnetic field to alternating magnetic field is in the range of 0.5-2.5, and the total intensity is in the range up to 100 mT. It provides non-invasive low toxicity and side effects, significantly inhibiting a plurality of tumors, influencing the intracellular superoxide radical content, and promoting cell autophagy. The mechanism of action of the magnetic field is on the electron spin energy levels and consequently on the free radicals concentration. Additional magnetic field having frequency up to 100 MHz and intensity down to microTesla range can be also used to improve the antitumor efficacy in combination with the static as well as the extremely low frequency electromagnetic field (1-300 Hz) influencing the spin hyperfine resonance. A combination method is also provided of a power-frequency electromagnetic field generating device and a platinum-based medicine.
    Type: Application
    Filed: February 7, 2018
    Publication date: January 16, 2020
    Applicants: ZHEJIANG UNIVERSITY
    Inventors: Santi TOFANI, Chen XI, Yuan LINQING, Shi KEXIN, Yang CHAO, Bian SUCHEN, Wang JINHU, Zhu KUN, Yang MIN, Gu WEIZHONG, Shang SHIQIANG, Li HUAMEI, Shen ZHENG, Wang CAN
  • Patent number: 8192969
    Abstract: A method and an apparatus for interfering with pathological cells survival processes, i.e. inducing directly or indirectly apoptosis, on living pathological cells, by using magnetic fields without adversely affecting normal cells. Static (S) and extremely low frequency (ELF) magnetic fields are used having low intensity comprised between 1 and 100 mT, preferably comprised between 1 and 30 mT. In particular SELF fields are used which are different sequences of S and/or ELF fields, i.e. S fields followed by ELF fields, ELF fields followed by S fields, S and ELF field together, as well as the presence of S or ELF fields alone, said ELF fields having a field frequency comprised between 1 and 1000 Hz. An apparatus for carrying out the method comprises means for generating static magnetic (S) fields crossing a working environment and/or means for generating electromagnetic extremely low frequency (ELF) fields over the working environment in addition to the S fields.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: June 5, 2012
    Inventor: Santi Tofani
  • Publication number: 20050267535
    Abstract: A method and an apparatus for interfering with pathological cells survival processes, i.e. inducing directly or indirectly apoptosis, on living pathological cells, by using magnetic fields without adversely affecting normal cells. Static (S) and extremely low frequency (ELF) magnetic fields are used having low intensity comprised between 1 and 100 mT, preferably comprised between 1 and 30 mT. In particular SELF fields are used which are different sequences of S and/or ELF fields, i.e. S fields followed by ELF fields, ELF fields followed by S fields, S and ELF field together, as well as the presence of S or ELF fields alone, said ELF fields having a field frequency comprised between 1 and 1000 Hz. An apparatus for carrying out the method comprises means for generating static magnetic (S) fields crossing a working environment and/or means for generating electromagnetic extremely low frequency (ELF) fields over the working environment in addition to the S fields.
    Type: Application
    Filed: June 28, 2005
    Publication date: December 1, 2005
    Inventor: Santi Tofani