Abstract: Provided herein are methods, computer programs, and systems for automated microinjection, for example, automated Intracytoplasmic Sperm Injection (ICSI).

Abstract: Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.

Abstract: Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.

Abstract: Described herein are devices, systems, and methods to aid in the manipulation of cells. The devices, methods, and systems disclosed herein can be applied towards, for example, automation of the in vitro fertilization process.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.

Abstract: Provided herein are methods and kits for determining receptivity status of an endometrium for embryonic implantation.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: A system for identifying genomic features in an embryo candidate is disclosed. The system includes a genomics sequencer, a computing device and a display. The genomic sequencer is configured to obtain sequence information from concatenated genomic fragments derived from an embryo candidate. The concatenated genomic fragments each contain at least one genomic linker segment and at least one genomic fragment from the embryo candidate. The computing device is communicatively connected to the genomic sequencer and includes a sequence alignment engine and a genomic features identification engine. The sequence alignment engine is configured to subtract out sequence information related to the genomic linker segment portion of the concatenated genomic fragments and align the genomic fragment sequences to a reference genome. The genomic features identification engine is configured to identify genomic features in the aligned genomic fragment sequences.

Abstract: Provided herein are methods and kits for determining receptivity status of an endometrium for embryonic implantation.

Abstract: The present disclosure provides methods and systems for generating a reproductive hormone profile of a subject. A method for generating a reproductive hormone profile of a subject may comprise (a) obtaining a hair sample of the subject; (b) processing the hair sample to generate data indicative of a presence of a reproductive hormone in the hair sample; and (c) processing at least some of the data of (b) using a reproductive hormone classifier to generate the reproductive hormone of the subject. The present disclosure also provides compositions and kits for performing methods described herein or using the systems described herein.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: Described herein are devices, systems, and methods to aid in the manipulation of cells. The devices, methods, and systems disclosed herein can be applied towards, for example, automation of the in vitro fertilization process.

Abstract: Provided herein are methods and kits for determining receptivity status of an endometrium for embryonic implantation.

Abstract: Materials and methods provided herein are useful for determining an implantation threshold for a euploid embryo and for determining the potential of a euploid embryo to implant and initiate a pregnancy.

Abstract: A full set of 24 chromosome-specific probes to analyze single cells or cell organelles to test for abnormalities is described. When used in an assay based on sequential hybridization, the full set is comprised of three subsets of chromosome-specific probes with each set comprised of 8 different probes. Also described are assays using a set of probes to analyze single cells and cellular organelles to accurately determine the number and type of targeted human chromosomes in various types of cells and cell organelles, such as tumor cells, interphase cells and first polar bodies biopsied from non-inseminated oocytes. Methods of selection or generation of suitable probes and hybridization protocols are described, as are preferred probes for frill set of 24 chromosome-specific probes to target all 24 human chromosomes are described in the Tables.

Abstract: Product and Methods are described for obtaining normal disomic stem cells from chromosomally abnormal embryos.