Patents by Inventor Santosh Kesari

Santosh Kesari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160324801
    Abstract: Compositions and methods useful to enhancing, improving, or eliciting anti-tumor immune responses are disclosed. A pterostilbene containing composition is administered to a cancer patient at a sufficient concentration and frequency to induce de-repression of tumor targeting immune responses. The composition enhances antibody dependent cellular toxicity (ADCC) and augments efficacy of antigen specific immunotherapeutics such as trastuzumab and other monoclonal antibody therapies useful for treating cancer.
    Type: Application
    Filed: July 7, 2016
    Publication date: November 10, 2016
    Inventors: Timothy G. Dixon, Gerry B. Berg, Robert F. Graham, Santosh Kesari, Thomas Ichim
  • Publication number: 20160250330
    Abstract: There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
    Type: Application
    Filed: February 24, 2016
    Publication date: September 1, 2016
    Inventors: Milan T. Makale, Wolfgang J. Wrasidlo, Santosh Kesari, Joanna McKittrick, Gustavo A. Hirata Flores, Olivia Graeve
  • Publication number: 20160237407
    Abstract: Disclosed are allogeneic cells useful for the treatment of cancer in a universal donor, off the shelf, manner. In one embodiment of the invention cord blood derived T cell progenitors are matured with anti-CD3 and anti-CD28, interleukin-7 and transfected with a construct encoding a chimeric antigen receptor (CAR) targeting a tumor antigen or a tumor endothelial associated antigen on the antigen binding domain. The intracellular domain containing CD3 zeta chain and at least one shRNA domain encoding a transcript which generates at least one siRNA capable of inhibiting expression of HLA I and/or HLA II. In another embodiment mesenchymal stem cells are transfected with CAR to enhance migration into tumors and induce tumor death, reduction of inflammation, or immune sensitization. In another embodiment universal donor CAR-MSC are disclosed.
    Type: Application
    Filed: February 17, 2016
    Publication date: August 18, 2016
    Applicant: Batu Biologics, Inc.
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Santosh Kesari, Boris Minev, Julia S. Szymanski
  • Publication number: 20160213764
    Abstract: Disclosed are composite cancer vaccines, in one embodiment generated through 3-dimensional bioprinting or through inoculation of roller cultures. The utilization of decellularized biological matrices such as placental tissue or subintestinal submucosal tissue is disclosed as a substrate for 3-dimensional tissue culture. In one embodiment tumor cells are assembled with monocytes and/or mesenchymal stem cells to represent in vivo existing tumors.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 28, 2016
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Santosh Kesari, Amit N. Patel
  • Publication number: 20160206717
    Abstract: Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses. The invention provides means of differentiating tumor cells directly into endothelial or endothelial-like cells and utilizing said cells as immunogens for the purpose of inducing immunity against blood vessels feeding tumors. In one embodiment glioma cells are cultured under hypoxic conditions in the presence of endothelial-differentiating factors. In another embodiment, PECAM-1 positive cells are derived from a tumor mass or cell line and utilized as an antigenic source to induce immunity towards tumor derived endothelial cells, endothelial-like cells, and tumor vascular channels.
    Type: Application
    Filed: January 19, 2016
    Publication date: July 21, 2016
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Santosh Kesari, Amit N. Patel
  • Publication number: 20160115549
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Application
    Filed: October 5, 2015
    Publication date: April 28, 2016
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Santosh Kesari, Brit Mollenhauer
  • Patent number: 9150928
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: October 6, 2015
    Assignees: The Brigham and Women's Hospital, Inc., The Regents of the University of California
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Brit Mollenhauer, Santosh Kesari
  • Publication number: 20150259326
    Abstract: Provided herein are novel compositions and methods to inhibit Olig2 activity. The Olig2 inhibitors and methods of using the same are useful, inter alia, for treating cancer. In particular the Olig2 inhibitors may be used to treat glioblastoma. Further, provided are peptide compositions capable of inhibiting Olig 2.
    Type: Application
    Filed: November 21, 2014
    Publication date: September 17, 2015
    Inventors: Santosh Kesari, Milan Makale, Wolf Wrasidlo, Rajesh Mukthavaram, Igor Flint Tsigelny, Valentina Lea Kouznetsova
  • Publication number: 20140356416
    Abstract: Provided herein are novel methods of making liposomally encapsulated drugs using reverse pH gradients and optimizing internal buffer compositions. Further provided herein are liposome compositions including an active pharmaceutical ingredient and uses thereof to treat a variety of diseases (e.g. cancer, inflammatory, neurological and cardiovascular diseases).
    Type: Application
    Filed: June 9, 2014
    Publication date: December 4, 2014
    Inventors: Santosh Kesari, Rajesh Mukthavaram, Milan Makale, Wolf Wrasidlo
  • Publication number: 20130344063
    Abstract: The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.
    Type: Application
    Filed: November 16, 2011
    Publication date: December 26, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Anna M. Krichevsky, Nadiya Teplyuk, Brit Mollenhauer, Santosh Kesari
  • Publication number: 20130184179
    Abstract: In alternative embodiments, the invention provides products of manufacture, such as arrays or microarrays, comprising cells and compounds such as small molecules or drugs for e.g., drug screening or toxicity testing.
    Type: Application
    Filed: August 19, 2011
    Publication date: July 18, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dayu Teng, Shu Chien, Santosh Kesari, Pengfei Jiang