Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.

Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Abstract: An air gasper knob system for an overhead Passenger Service Unit (PSU) includes an annular gasper knob of a UV transparent material. The annular gasper knob defines an air passage therethrough, and extends about the air passage from a first annular end face to a second annular end face. The system also includes a UV illuminator mounted to the gasper knob, oriented to transmit UV illumination through the UV transparent material to sanitize exterior surfaces of the gasper knob. A method of sanitizing an air gasper knob comprises illuminating a gasper knob in an overhead PSU using UV illumination to destroy infectious agents on surfaces of the gasper knob.

Abstract: A computing device is provided, including a storage device configured to store image data and a processor coupled to a memory that stores instructions, which, upon execution by the processor, cause the processor to select a target image from the image data. The processor is further configured to display conversion possibility information that indicates that the target image can be converted into a larger image that has a larger field of view by stitching other images together with at least a portion of the target image and an associated selector. The processor is further configured to display the larger image upon receiving a user selection of the selector.

Abstract: Embodiments herein disclose systems and methods for relay selection in mmWave networks, wherein the relay is selected using a Q-learning based method and the selected relay can be used by a source for communication with a destination in each time slot. Embodiments herein disclose systems and methods for relay selection in mmWave networks, wherein there are multiple source-destination pairs, and a relay is assigned to each source-destination pair in each time slot using the Q-learning based method.

Abstract: In an example implementation consistent with the features disclosed herein, high availability of a stateful application is achieved by orchestrating multiple computing clusters. A stateful application is deployed at a first application operator and a second application operator of a first computing cluster and a second computing cluster, respectively. The first application operator includes a first control loop that changes the first computing cluster based on first resources of the first computing cluster. The second application operator includes a second control loop that changes the second computing cluster based on second resources of the second computing cluster. Synchronization of the first resources with the second resources is configured, such as via an object storage service. The first application operator and the second application operator are scaled to, respectively, nonzero and zero. A load balancer is configured to route requests to the first computing cluster.

Abstract: An environmental control system includes an ambient air conduit and a bleed air conduit, an electric compressor connected to the ambient air conduit and a mechanical compressor connected to the electric compressor. The electric compressor is supported for rotation independent of the mechanical compressor. A turbine is operatively connected to the mechanical compressor, the turbine connected to both the ambient air conduit and the bleed air conduit to provide conditioned air to a conditioned air conduit. Computer program products and methods of providing conditioned air to conditioned air loads are also described.

Abstract: Disclosed herein are approaches for in-situ verification and correction of a wafer position. In one approach, a method may include illuminating an underside of a platen positioned within a processing chamber, and detecting a perimeter edge of the platen using an imaging device positioned external to the processing chamber, above the platen. The method may further include determining, via a controller, position data for the platen based on the detected perimeter edge of the platen, and positioning a wafer atop the platen based on the position data of the platen, wherein the wafer comprises a positioning notch.

Abstract: A system and method are disclosed to locate one or more data anomalies in a supply chain network comprising two or more supply chain entities. Embodiments receive supply chain data comprising a plurality of data points. Embodiments select categories and measures by which to cluster the supply chain data points. Embodiments cluster the data points into intersection clusters as measured by the selected categories and measures. Embodiments generate time interval clusters that divide the intersection clusters into one or more time intervals. Embodiments generate K-values for the plurality of data points in relation to the number of time interval clusters. Embodiments generate local outlier factors for the plurality of data points using the generated K-values.

Abstract: The present disclosure is directed to inhibitors of Formula (0), or a stereoisomer thereof, or pharmaceutically acceptable salt thereof, of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Abstract: A system and method are disclosed for virtual planogram automation with computer vision, comprising a retail entity comprising a product display area; and a planogram planner configured to access images of products prior to the display of the products in the product display area, classify the images by using a convolutional neural network, assign a bounding box to the products identified in the images, localize and detect objects and estimate product dimensions corresponding to the objects, determine changes in the estimated product dimensions by comparing the estimated product dimensions with corresponding baseline product dimensions to determine whether product dimensions has changed, and determine a total area remaining in a simulated planogram for alternative product placements after factoring in the determined changes in product dimensions.

Abstract: Executing workflows with different computations on different types of remote computing devices is difficult and time consuming, sometimes taking days. A system of computing devices is provided to generate a workflow of computing tasks that specify different types of computing hardware resources, including quantum computing and classical computing resources, and to generate a schedule of jobs to be executed that is consistent with the workflow. The schedule of jobs is automatically executed, as computational tasks are dispatched to different computing resource providers at different times. Two or more computational tasks can be dispatched in parallel and at the same time, according to parallel tasks in the workflow.

Abstract: Various embodiments include techniques for performing self-synchronizing remote memory operations in a multiprocessor computing system. During a remote memory operation in the multiprocessor computing system, a source processing unit transmits multiple segments of data to a destination processing. For each segment of data, the source processing unit transmits a remote memory operation to the destination processing unit that includes associated metadata that identifies the memory location of a corresponding synchronization object. The remote memory operation along with the metadata is transmitted as a single unit to the destination processing unit. The destination processing unit splits the operation into the remote memory operation and the memory synchronization operation. As a result, the source processing unit avoids the need to perform a separate memory synchronization operation, thereby reducing inter-processor communications and increasing performance of remote memory operations.

Abstract: A cascaded thin-oxide N-Well voltage steering circuit includes a reference voltage generator that outputs a reference voltage within a range of first and second supply voltages, a first voltage steering circuit that outputs a higher available one of the reference voltage and the second supply voltage as an interim voltage, and a second voltage steering circuit that outputs a higher available one of the first voltage and the interim voltage at an output of the second voltage steering circuit. The interim voltage is applied to N-wells of PMOS transistors of the first voltage steering circuit. The output of the second voltage steering circuit is applied to N-wells of PMOS transistors of the second voltage steering circuit. The output of the second voltage steering circuit may also be applied to N-wells of PMOS transistors of other circuitry. The cascaded thin-oxide N-Well voltage steering circuit may consist substantially of thin-oxide PMOS transistors.

Abstract: Briefly, embodiments of a system, method, and article for receiving a request, via a user interface, from a first backend system on a central exchange. The request may be for a determination of a schema for documentation produced by a second backend system on the central exchange. The second backend system may engage in one or more transactions with the first backend system. The first backend system may be integrated with the central exchange. The schema for the documentation generated by the second backend system over the central exchange may be automatically determined. Rules for transactions with the second backend system may be automatically determined. The schema and rules for the second backend system may be automatically combined. The integration package may be automatically generated and deployed within a conversion layer of the first backend system.

Abstract: A system receives one or more transcripts of communications between entities. The system identifies a requested action in the communications based at least in part on a mapping between the requested action and an application programming interface. The system identifies one or more statements eliciting information, based on parameters to the application programming interface. The system generates a definition of an artificial agent based, at least in part, on the requested action and the one more statements eliciting information.

Abstract: A stator core includes a first end and a second end separated along an axis. The stator core includes an inner radial surface and an outer radial surface. Also, the stator core includes an outer coolant groove defined on the outer radial surface of the stator core. The outer coolant groove extends about the axis. Additionally, the stator core includes a yoke flow channel extending through the stator core along the axis. The yoke flow channel is in fluid communication with the outer coolant groove. Furthermore, the outer coolant groove configured to receive coolant of the fluid coolant system and provide the coolant to the yoke flow channel, which provides the coolant to at least one of the first end and the second end.