Patents by Inventor Santosh Kumar Srivastava
Santosh Kumar Srivastava has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9018226Abstract: The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and ?-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R.Type: GrantFiled: March 31, 2010Date of Patent: April 28, 2015Assignee: Council of Scientific & Industrial ResearchInventors: Santosh Kumar Srivastava, Ashok Kumar Agrawal, Subhash Chandra Singh, Vinay Kumar Khanna, Janardan Singh, Chandeshwar Nath, Madan Mohan Gupta, Shikha Gupta, Ram Kishor Verma, Anirban Pal, Dnyaneshwar Umrao Bawankule, Dharmendra Saikia, Anil Kumar Gupta, Anupam Maurya, Suman Preet Singh Khanuja
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Publication number: 20130184462Abstract: The present invention relates to the development of a virtual screening model for predicting antipsychotic activity using quantitative structure activity relationship (QSAR), molecular docking, oral bioavailability, ADME and Toxicity studies. The present invention also relates to the development of QSAR model using forward stepwise method of multiple linear regression with leave-one-out validation approach. QSAR model showed activity-descriptors relationship correlating measure (r2) 0.87 (87%) and predictive accuracy of 81% (rCV2=0.81). The present invention specifically showed strong binding affinity of the untested (unknown) novel compounds against anti-psychotic targets viz., Dopamine D2 and Serotonin (5HT2A) receptors through molecular docking approach. Theoretical results were in accord with the in vitro and in vivo experimental data. The present invention further showed compliance of Lipinski's rule of five for oral bioavailability and toxicity risk assessment for all the active Yohimbine derivatives.Type: ApplicationFiled: September 30, 2011Publication date: July 18, 2013Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Santosh Kumar Srivastava, Feroz Khan, Shikha Gupta, Dharmendra K. Yadav, Vinay Kumar Khanna
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Publication number: 20120184576Abstract: The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-der?ethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and ?-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkabids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R.Type: ApplicationFiled: March 31, 2010Publication date: July 19, 2012Inventors: Santosh Kumar Srivastava, Ashok Kumar Agrawal, Subhash Chandra Singh, Vinay Kumar Khanna, Janardan Singh, Chandeshwar Nath, Madan Mohan Gupta, Shikha Gupta, Ram Kishor Verma, Anirban Pal, Duyaneshwar Umrao Bawankule, Dharmendra Saikia, Anil Kumar Gupta, Anupam Maurya, Suman Preet Singh Khanuja
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Patent number: 7797334Abstract: A tool can automate the process of downloading from a mainframe to a local area network (LAN). A back-end tool and a front-end tool can cooperate to accomplish the downloading process. Both tools can simplify the download process, avoiding complications and common errors. A user interface can provide features for simplifying the download process. Files can be downloaded from separate sub-areas on the mainframe to respective separate sub-areas on the LAN. Download settings can be saved and later retrieved via a name. Downloading for multiple software projects can be supported.Type: GrantFiled: December 20, 2006Date of Patent: September 14, 2010Assignee: Infosys Technologies Ltd.Inventors: Santosh Kumar Srivastava, Sathish Babu Namasivayam, Mahipal Pukhraj Jain
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Patent number: 7767798Abstract: The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of Strychnos nux-vomica and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.Type: GrantFiled: March 2, 2006Date of Patent: August 3, 2010Assignee: Council of Scientific & Industrial ResearchInventors: Suman Preet Singh Khanuja, Santosh Kumar Srivastava, Ankur Garg, Merajuddin Khan, Mahendra Pandurang Dardokar, Anirban Pal
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Patent number: 7435433Abstract: The present invention provides an improved process for the isolation of oleane compounds from the bark of Terminalia arjuna (Roxb.). More particularly, the present invention relates to an improved process for the isolation of arjunic acid and its derivates from the bark of Terminalia arjuna (Roxb.). The present invention further provides the identification of arjunic acid [1] and its derivatives as anticancer agent useful in the treatment of various types of cancer in humans.Type: GrantFiled: March 31, 2006Date of Patent: October 14, 2008Assignee: Council of Scientific & Industrial ResearchInventors: Suman Preet Singh Khanuja, Madan Mohan Gupta, Santosh Kumar Srivastava, Tiruppadiripuliyur Ranganathan Santha Kumar, Digvijay Singh, Subash Chandra Verma, Ankur Grag, Merajuddin Khan, Ram Kishor Verma, Raghavendra Kumar Mishra, Subash Chandra Singh
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Patent number: 6893668Abstract: The present invention relates to an improved and economical process for the isolation of anticancer agent Camptothecin from the twigs and stem of Nothapodytes foetida using hot extraction 20(S) Camptothecin is an alkaloid, which contains a pentacyclic ring system that includes a pyrrolo [3,4-b] quinoline moiety (ring A, B and C), the pyridone ring D and a chiral center at C-20 in ring E.Type: GrantFiled: March 31, 2003Date of Patent: May 17, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Santosh Kumar Srivastava, Merajuddin Khan, Suman Preet Singh Khanuja
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Patent number: 6884908Abstract: Accordingly the present invention provides an improved and economical process for the isolation of oleanolic acid from the roots of Lantana camara, which comprises of drying, grinding and defattening of Lantana camara roots with light petroleum followed by over night extractions at room temperature (30-40° C.) three times with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH etc., removal of solvent under vacuum at 35-45° C., precipitation of crude extract and repeated partial crystallization of precipitate with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH, H2O and others resulting in the isolation of oleanolic acid with 1% yield.Type: GrantFiled: March 30, 2004Date of Patent: April 26, 2005Assignee: Council of Scientific & Industrial ResearchInventors: Santosh Kumar Srivastava, Merajuddin Khan, Suman Preet Singh Khanuja
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Patent number: 6858588Abstract: The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (?) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.Type: GrantFiled: March 31, 2003Date of Patent: February 22, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Suman Preet Singh Khanuja, Jai Shanker Arya, Ranganathan Santha Kumar Tiruppadiripuliyur, Dharmendra Saikia, Harpreet Kaur, Monika Singh, Subhash Chandra Gupta, Ajit Kumar Shasany, Mahendra Pandurang Darokar, Santosh Kumar Srivastava, Madan Mohan Gupta, Subash Chandra Verma, Anirban Pal
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Publication number: 20040220425Abstract: Accordingly the present invention provides an improved and economical process for the isolation of oleanolic acid from the roots of Lantana camara, which comprises of drying, grinding and defattening of Lantana camara roots with light petroleum followed by over night extractions at room temperature (30-40° C.) three times with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH etc., removal of solvent under vacuum at 35-45° C., precipitation of crude extract and repeated partial crystallization of precipitate with a single solvent selected from CH2Cl2, CHCl3, EtOAc, ether, acetone, MeOH, EtOH, H2O and others resulting in the isolation of oleanolic acid with 1% yield.Type: ApplicationFiled: March 30, 2004Publication date: November 4, 2004Inventors: Santosh Kumar Srivastava, Merajuddin Khan, Suman Preet Singh Khanuja
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Publication number: 20040198669Abstract: The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.Type: ApplicationFiled: March 31, 2003Publication date: October 7, 2004Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Suman Preet Singh Khanuja, Jai Shanker Arya, Ranganathan Santha Kumar Tiruppadiripuliyur, Dharmendra Saikia, Harpreet Kaur, Monika Singh, Subhash Chandra Gupta, Ajit Kumar Shasany, Mahendra Pandurang Darokar, Santosh Kumar Srivastava, Madan Mohan Gupta, Subash Chandra Verma, Anirban Pal
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Publication number: 20040198815Abstract: The present invention relates to the new use of an already known biomolecule methyl-&bgr;-orcinol carboxylate of formula 1 isolated from a lichen (Everniastrum cirrhatum), for treating pathogenic fungal infections of humans that are resistant to polyene and azole antibiotics such as amphotericin B, nystatin, clotrimazole etc.Type: ApplicationFiled: March 31, 2003Publication date: October 7, 2004Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Suman Preet Singh Khanuja, Ranganathan Santha Kumar Tiruppadiripuliyur, Vivek Kumar Gupta, Preeti Chand, Ankur Garg, Santosh Kumar Srivastava, Subash Chandra Verma, Dharmendra Saikia, Mahendra Pandurang Darokar, Ajit Kumar Shasany, Anirban Pal
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Publication number: 20040192917Abstract: The present invention relates to an improved and economical process for the isolation of anticancer agent Camptothecin from the twigs and stem of Nothapodytes foetida using hot extraction 20(S) Camptothecin is an alkaloid, which contains a pentacyclic ring system that includes a pyrrolo [3,4-b] quinoline moiety (ring A, B and C), the pyridone ring D and a chiral centre at C-20 in ring E.Type: ApplicationFiled: March 31, 2003Publication date: September 30, 2004Inventors: Santosh Kumar Srivastava, Merajuddin Khan, Suman Preet Singh Khanuja
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Publication number: 20030181425Abstract: The present invention relates to pharmaceutical composition with lysergol as bioactive enhancer and bioavailability facilitator for broad-spectrum antibiotics. The present invention has direct implication in reducing the dosage of antibiotics while increasing the efficiency of absorption of nutritional elements.Type: ApplicationFiled: March 25, 2002Publication date: September 25, 2003Inventors: Suman Preet Singh Khanuja, Jai Shankar Arya, Santosh Kumar Srivastava, Ajit Kumar Shasany, Tiruppadiripuliyur Ranganathan Santha Kumar, Mahendra Pandurang Darokar, Sushil Kumar