Patents by Inventor Santosha A. Vardhana

Santosha A. Vardhana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-INVASIVE METHODS FOR SELECTIVELY ENRICHING PLURIPOTENT CELLS
    Publication number: 20220306986
    Abstract: The present disclosure provides highly efficient, non-invasive, and reversible methods for selectively enriching pluripotent cells (e.g., human pluripotent cells and mouse pluripotent cells) in a cell population using a glutamine-deficient medium. The presently disclosed methods have the advantageous of efficiently enriching pluripotent cells in a heterogenous cell population without altering the biological properties of any individual cells.
    Type: Application
    Filed: October 29, 2021
    Publication date: September 29, 2022
    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Lydia W.S. Finley, Craig B. Thompson, Santosha A. Vardhana
  • T-CELL EXHAUSTION, METHODS & COMPOSITIONS RELATING THERETO
    Publication number: 20210077529
    Abstract: The present invention provides methods for the induction and monitoring of T cell exhaustion in vitro. The methods are effective for both human and non-human T cells, and for both antigen-specific and polyclonal T cells. The present invention also provides methods to screen for and/or evaluate pharmacologic agents that can either induce or reverse T cell exhaustion. The present invention also provides certain agents that can reverse T cell exhaustion.
    Type: Application
    Filed: April 16, 2019
    Publication date: March 18, 2021
    Inventors: Santosha Vardhana, Lydia Whitney Stillman Finley, Craig B. Thompson