Abstract: Chromium-three cation containing compositions in synergistic combination with Phyllanthus emblica extract and Shilajit are useful for improvement of endothelial function and cardiovascular health, including treatment of type 2 diabetes and metabolic syndrome.

Abstract: Chromium-three cation containing compositions in combination with Phyllanthus emblica extract and Shilajit are useful for improvement of endothelial function and cardiovascular health, including treatment of type 2 diabetes and metabolic syndrome.

Abstract: A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.

Abstract: A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino-withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.

Abstract: The present invention provides an optimized and/or enriched hydrolyzable tannoid blend derived from Terminalia chebula. In an embodiment the present invention further relates to the use of an extract of Terminalia chebula for treatment of osteoarthritis. In another embodiment, a T. chebula extract composition contains about 8-25% by weight chebulagic acid, about 15-30% by weight chebulinic acid and about 10-40% by weight other low molecular weight hydrolyzable tannoids. This embodiment provides a T. chebula enriched tannoid blend composition (TC/enriched tannoid blend). In another embodiment, a method of treating osteoarthritis in an individual is provided, comprising administering to the individual in need thereof a therapeutically effective amount of the T. chebula extract composition.

Abstract: Compositions of natural antioxidants, especially those derived from Phyllanthus emblica and Withania somnifera, and combinations thereof, are provided. The compositions may be used for improvement of endothelial function and cardiovascular health, including treatment of diabetes.

Abstract: Compositions containing extracts of Terminalia chebula and Terminalia bellerica, or combinations thereof and methods for treatment of uricemia, hyperuricemia, and gout in a human subject are provided.

Abstract: An accelerated powder segregation testing apparatus and method are disclosed. The apparatus consists of an angularly oriented ramp 10 mounted on a vibration device 22. The powder to be tested is fed into an origin portion 14 of the ramp 10, and when the vibrator 22 is activated, the powder moves along the ramp 10. As the powder exits after the test, unit-dose powder samples are collected, compacted and analyzed for differential in content uniformity. By comparing the results from several formulations, the formulation that is most resistant to segregation can be selected for production.

Abstract: Chromium-three cation in combination with Phyllanthus emblica extract and Shilajit is useful in treating symptoms associated with osteoarthritis including reduction of inflammation and pain in a mammal, particularly a human or an animal. The combination shows significant reduction in overall pain levels and other pain measures in a canine model, and in human studies. Thus the composition is an anti-arthritic formulation that decreases pain and inflammation.

Abstract: A tumbling container is mounted for rotation with a curved screen fixedly mounted within the tumbling container. A multiple vane paddle is mounted to a shaft that is rotatably mounted to the tumbling container. The paddle vanes are formed with angular edges. As the tumbler rotates and the paddle rotates, powder is repeatedly dropped onto the screen to be sifted with the aid of the paddle. Rotating the tumbler further drops unsifted portions of the powder from the screen to mix with additional powder in the tumbler body. Thus, sifting and blending of powders is accomplished in one single operation. The invention utilizes an apparatus having a multiple section screen and a multiple section paddle to enable assembly through the openings in the tumbling container. The screen of a second embodiment has a cowl adjacent to each screen opening to optimize powder lump disintegration.

Abstract: Shilajit in a standardized composition produces a significant improvement in several cardiovascular parameters including RI, AIx and SEVR. Further, significant reductions in malondialdehyde and increases in nitric oxide levels are provided suggesting improvement in endothelial function. Shilajit may be used to reduce inflammatory biomarker HsCRP levels significantly compared to baseline and placebo. Additionally, Shilajit can provide significant improvement in lipid parameters including total cholesterol, LDL-C, and HbA1c (%) Inhibition of platelet aggregation using Shilajit performed using ADP as aggregant also provides highly significant inhibition of platelet aggregation compared to baseline and with placebo. Thus, Shilajit may be used for improvement of endothelial function and to help reduce cardiovascular morbidity, particularly for the diabetic individual.

Abstract: A tumbling container is mounted for rotation with a curved screen fixedly mounted within the tumbling container. A multiple vane paddle is mounted to a shaft that is rotatably mounted to the tumbling container. The paddle vanes are formed with angular edges. As the tumbler rotates and the paddle rotates, powder is repeatedly dropped onto the screen to be sifted with the aid of the paddle. Rotating the tumbler further drops unsifted portions of the powder from the screen to mix with additional powder in the tumbler body. Thus, sifting and blending of powders is accomplished in one single operation. The invention utilizes an apparatus having a multiple section screen and a multiple section paddle to enable assembly through the openings in the tumbling container. The screen of a second embodiment has a cowl adjacent to each screen opening to optimize powder lump disintegration.

Abstract: An enriched hydrolyzable tannoid blend derived from Terminalia chebula is provided. An optimized aqueous extraction method for Terminalia chebula is provided to maximize the levels of bioactive hydrolyzable tannoids including chebulagic acid, chebulinic acid and other low molecular weight hydrolyzable tannoids. The method produces a Terminalia chebula extract containing a hydrolyzable tannoid blend as an amorphous dry powder. In an embodiment, the Terminalia chebula extract contains 8-25% by weight chebulagic acid, 15-30% chebulinic acid, and 5-45% low molecular weight hydrolyzable tannoids. Potential uses of said enriched hydrolyzable tannoid compositions for antioxidant activity in a human subject are described herein.

Abstract: Compositions of natural antioxidants, especially those derived from Phyllanthus emblica and Withania somnifera, and combinations thereof, are provided. The compositions may be used for improvement of endothelial function and cardiovascular health, including treatment of diabetes.

Abstract: A tumbler is mounted for rotation around a trunnion with a screen fixedly mounted to a portion of the trunnion residing within the tumbler. A multiple blade paddle is mounted to a shaft that is rotatably supported through the trunnion. The paddle blades are formed with angular edges. As the tumbler rotates and the paddle rotates, powder is repeatedly dropped onto the screen to be sifted with the aid of the paddle. Rotating the tumbler further drops unsifted portions of the powder from the screen to mix with additional powder in the tumbler body. Thus, sifting and blending of powders is accomplished in one single operation.

Abstract: A tumbler is mounted for rotation around a trunnion with a screen fixedly mounted to a portion of the trunnion residing within the tumbler. A multiple blade paddle is mounted to a shaft that is rotatably supported through the trunnion. The paddle blades are formed with angular edges. As the tumbler rotates and the paddle rotates, powder is repeatedly dropped onto the screen to be sifted with the aid of the paddle. Rotating the tumbler further drops unsifted portions of the powder from the screen to mix with additional powder in the tumbler body. Thus, sifting and blending of powders is accomplished in one single operation.

Abstract: A sampler for acquiring a sample of blended powder from diverse locations within a bin is described. The sampler has a cylinder with a hollow chamber formed therein and is connected to a handle for rotation within a housing tube. Rotation causes the chamber to move into or out of alignment with an aperture in the housing tube. When the sampler is inserted axially into a batch of blended powder, the cylinder is rotated to align the chamber with the aperture in the housing cap, allowing powder to enter the chamber. The cylinder is rotated back to close the chamber, and the sampler is withdrawn from the powder batch. The cap is removed from the housing and the cylinder is removed from the housing to transfer the sample of powder for analysis.

Abstract: The powder analytical apparatus of the invention includes a hopper that is connected to a controllable agitator by a separable link. The hopper has an exit port at its lower end that is at an acute angle to the axis of the hopper. A planar gate is mounted parallel to the exit port of the hopper and is movable incrementally to allow powder to flow out of the hopper into a bin residing on a scale. The controllable agitator is a vibrator device capable of variation of frequency and amplitude. Control of the vibrator, the gate position and input from the scale are by means of a PLC. In a second embodiment, the exit port is formed perpendicular to the axis of the hopper and the gate is conical to emulate the angular flow pattern of the first embodiment.

Abstract: The present invention provides apparatus and method for sample acquisition from an active flow of mixed powder material being transferred from a blender. The apparatus includes a sleeve that is assembled co-axially to a discharge port of the blender and a number of sample collectors which each include a shaft with sample cavities and a tube that is rotatable around the shaft for exposing and covering the cavities. The sample collectors are alternately inserted through a bearing collar into the sleeve. The tubes are plugged at their respective outer ends to prevent accidental removal from the sleeve. The method includes inserting and opening each of the sample collectors in turn and removing the collected samples for analysis.

Abstract: A sampling die and press for compaction of a powder sample are disclosed. The die is designed to serve both as a mold for compacting a powder sample into a tablet or caplet and as a container for sampling the powder that is to be compacted. The die is made in two pieces with the top piece of the die having a passage and the bottom piece of the die sealing the bottom opening of the passage to form a mold cavity. The invention also includes a press adapted for compacting a powder sample contained within the mold cavity of a die which serves both as a sampling container for the powder and as a mold for compaction of the powder.